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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rabgef1tm2Glli
targeted mutation 2, Stephen J Galli
MGI:3051238
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rabgef1tm2Glli/Rabgef1tm2Glli WBB6F1 MGI:3051407


Genotype
MGI:3051407
hm1
Allelic
Composition		 Rabgef1tm2Glli/Rabgef1tm2Glli
Genetic
Background		 WBB6F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rabgef1tm2Glli mutation (0 available); any Rabgef1 mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:91790 )
• all died within the first 24 hours of life

immune system
increased interleukin-6 secretion ( J:91790 )
• increased IL-6 release in response to high affinity IgE receptor aggregation
increased tumor necrosis factor secretion ( J:91790 )
• increased TNF release in response to high affinity IgE receptor aggregation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory