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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(CAG-OVAL)916Jen
transgene insertion 916, Marc K Jenkins
MGI:3050829
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(CAG-OVAL)916Jen/? C57BL/6-Tg(CAG-OVAL)916Jen MGI:3789191


Genotype
MGI:3789191
tg1
Allelic
Composition
Tg(CAG-OVAL)916Jen/?
Genetic
Background
C57BL/6-Tg(CAG-OVAL)916Jen
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-OVAL)916Jen mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• most cells of the body express a membrane bound form of chicken ovalbumin on their cell surface

immune system
• dendritic cells in the skin present an epitope of chicken ovalbumin in complex with the MHC allele Kb
• splenocytes are able to activate OT-I and OT-II transgenic T cells when cultured in vitro
• full thickness tail skin grafted from transgenic mice to C57BL/6 mice have a mean survival time of 33.9 days compared a mean survival time of over 200 days for non-transgenic donors
• recipient mice show accelerated rejection (18 days) when grafted with transgenic tail skin a second time
• recipient mice also show accelerated rejection when adoptively transferred with OT-I or OT-II T cells (OT-I = Tg(TcraTcrb)1100Mjb, OT-II = Tg(TcraTcrb)425Cbn)
• when recipient mice lack T cells (Tcratm1Mom homozygotes), rejection of the transgenic skin grafts fail to occur
• when recipient mice lack CD8 T cells (Cd8atm1Mak homozygotes), transgenic skin grafts shrink rapidly to 10-30% of their original size but then survive indefinitely
• when recipient mice lack CD4 T cells (H2-Ab1tm1Gru homozygotes), transgenic skin grafts remain healthy for the first 40 days after which they start progressively contracting with 25% of the grafts being lost by 115 days





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last database update
01/04/2022
MGI 6.17
The Jackson Laboratory