All Phenotypes Gnas<tm1Jop> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gnas^tm1Jop
targeted mutation 1, Jo Peters
MGI:3050794

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Gnas^tm1Jop/Gnas⁺	involves: 129S/SvEv * C57BL/6	MGI:3051502
ht2	Gnas^Oedsml/Gnas^tm1Jop	involves: 129S/SvEv * C57BL/6	MGI:3051503

Allelic Composition	Gnas^tm1Jop/Gnas⁺
Genetic Background	involves: 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnas^tm1Jop mutation (0 available); any Gnas mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:91717 )

• mice carrying the allele, regardless if its inherited maternally or paternally, are viable, healthy, and fertile

Allelic Composition	Gnas^Oedsml/Gnas^tm1Jop
Genetic Background	involves: 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnas^Oedsml mutation (0 available); any Gnas mutation (53 available)
Gnas^tm1Jop mutation (0 available); any Gnas mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal heart size ( J:91717 )

• the heart weight to body length ratio is significantly reduced compared to wild-type littermates, however neither heart weight nor body length alone are significantly reduced

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:91717 )

N	• unlike Gnas^Oedsml-mat heterozygotes, compound heterozygotes are viable and do not display hypocalcemia, hyperphosphatemia, elevated circulating parathyroid hormone levels, gross edema, or brown fat abnormalities

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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