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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Dnmt3atm3.2Enl
targeted mutation 3.2, En Li
MGI:3047824
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Dnmt3atm3.2Enl/Dnmt3atm3.2Enl involves: 129S4/SvJae MGI:3047841
cn2
Alpltm1(cre)Nagy/Alpl+
Dnmt3atm3.1Enl/Dnmt3atm3.2Enl
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ MGI:3047840


Genotype
MGI:3047841
hm1
Allelic
Composition
Dnmt3atm3.2Enl/Dnmt3atm3.2Enl
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt3atm3.2Enl mutation (0 available); any Dnmt3a mutation (138 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygotes die at about 4 weeks of age

growth/size/body
• homozygotes appear normal at birth but do not grow as well as wild-type mice




Genotype
MGI:3047840
cn2
Allelic
Composition
Alpltm1(cre)Nagy/Alpl+
Dnmt3atm3.1Enl/Dnmt3atm3.2Enl
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alpltm1(cre)Nagy mutation (6 available); any Alpl mutation (351 available)
Dnmt3atm3.1Enl mutation (2 available); any Dnmt3a mutation (138 available)
Dnmt3atm3.2Enl mutation (0 available); any Dnmt3a mutation (138 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• testes weight is greatly reduced at 11 weeks of age

reproductive system
• at P11 the number of spermatogonia are reduced and by 11 weeks of age few spermatogonia and no spermatocytes, spermatids, or spermatozoa are seen
• testes weight is greatly reduced at 11 weeks of age
• all embryos die around E10.5 with open neural tubes, absent branchial arches and pale skin
• this is a maternal effect mutation resulting from impaired maternal imprinting
• no pregnancies result from crossing mutant males with wild-type females

cellular
• at P11 the number of spermatogonia are reduced and by 11 weeks of age few spermatogonia and no spermatocytes, spermatids, or spermatozoa are seen





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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory