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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Prnp/Prndtm1Aag
targeted mutation 1, Adriano Aguzzi
MGI:3047634
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Prnp/Prndtm1Aag/Prnp/Prndtm1Aag Not Specified MGI:3047645


Genotype
MGI:3047645
hm1
Allelic
Composition
Prnp/Prndtm1Aag/Prnp/Prndtm1Aag
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnp/Prndtm1Aag mutation (1 available); any Prnd mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mutants do not develop tremor or ataxia unlike Prnptm2.1Cwe homozygotes

cellular
• sperm malformations similar to those in Prdntm1Aag are seen

immune system
N
• immune system function and cell populations are normal

reproductive system
• sperm malformations similar to those in Prdntm1Aag are seen
• male but not female mutants are infertile

nervous system
N
• mutants maintain intact Purkinje cell layers, have normal size cerebella, and do not develop gliosis unlike Prnptm2.1Cwe homozygotes





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory