Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf2tm2Gth mutation
(3 available);
any
Nf2 mutation
(65 available)
Tg(Mpz-cre)3Brn mutation
(0 available)
Trp53tm1Brd mutation
(5 available);
any
Trp53 mutation
(232 available)
|
|
|
mortality/aging
|
• 4 of 12 mice die prematurely due to malignant peripheral nerve sheath tumors, 3 of which are 5 months old
|
neoplasm
nervous system
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf2tm2Gth mutation
(3 available);
any
Nf2 mutation
(65 available)
Tg(Mpz-cre)3Brn mutation
(0 available)
Trp53tm1Brd mutation
(5 available);
any
Trp53 mutation
(232 available)
|
|
|
mortality/aging
|
• mice exhibit a decrease in survival rate when the Nf2 and Trp53 alleles are carried in cis as opposed to trans, but live longer than conditional mutants carrying Tg(P0-Cre)2Gth
|
neoplasm
|
• between 3.5 and 13.5 months,19% of mice develop malignant peripheral nerve sheath tumors when the Nf2 and Trp53 alleles are carried in cis
• however, no tumors form in mice when the Nf2 and Trp53 alleles are carried in trans
|
|
• when the Nf2 and Trp53 alleles are carried in trans mice develop osteogenic tumors not restricted to neural crest-derived bone
|
|
• 81% of mice develop osteogenic (osteomas and osteosarcomas) tumors when the Nf2 and Trp53 alleles are carried in cis
|
|
• 81% of mice develop osteogenic (osteomas and osteosarcomas) tumors when the Nf2 and Trp53 alleles are carried in cis
|
skeleton
|
• when the Nf2 and Trp53 alleles are carried in trans mice develop osteogenic tumors not restricted to neural crest-derived bone
|
|
• 81% of mice develop osteogenic (osteomas and osteosarcomas) tumors when the Nf2 and Trp53 alleles are carried in cis
|
|
• 81% of mice develop osteogenic (osteomas and osteosarcomas) tumors when the Nf2 and Trp53 alleles are carried in cis
|
nervous system
|
• between 3.5 and 13.5 months,19% of mice develop malignant peripheral nerve sheath tumors when the Nf2 and Trp53 alleles are carried in cis
• however, no tumors form in mice when the Nf2 and Trp53 alleles are carried in trans
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf2tm2Gth mutation
(3 available);
any
Nf2 mutation
(65 available)
Tg(Mpz-cre)3Brn mutation
(0 available)
|
|
|
neoplasm
|
• 12% of mice exhibit fibroadenoma in the mammary gland
|
|
• 30% of mice develop osseous metaplasia
|
|
• 18% of mice develop carcinoma in situ in the kidney
|
|
• 30% of mice develop stromal sarcoma
|
|
• 6% of mice develop neurofibrosarcoma
|
|
• 6% of mice exhibit odontoma
|
|
• 30% of mice develop osseous metaplasia
(J:63264)
• 6% of mice exhibit odontoma
(J:63264)
• 35% of mice develop schwannomas
(J:92413)
|
|
• 6% of mice develop osteoma
|
skeleton
|
• 12% of mice exhibit odontoblastic hyperplasia
|
|
• 6% of mice develop osteoma
|
|
• osteogenic hyperplasia in 47% of mice
|
nervous system
|
• 6% of mice develop neurofibrosarcoma
|
|
• 30% of mice develop osseous metaplasia
(J:63264)
• 6% of mice exhibit odontoma
(J:63264)
• 35% of mice develop schwannomas
(J:92413)
|
|
• 82% of mice exhibit Schwann cell hyperplasia
|
renal/urinary system
|
• 18% of mice develop carcinoma in situ in the kidney
|
|
• 53% of mice exhibit renal tubular cell hyperplasia
|
vision/eye
|
• in 14% to 18% of mice, in which 50% of cases are bilateral
|
craniofacial
|
• 12% of mice exhibit odontoblastic hyperplasia
|
growth/size/body
|
• 12% of mice exhibit odontoblastic hyperplasia
|
respiratory system
integument
|
• 12% of mice exhibit fibroadenoma in the mammary gland
|
endocrine/exocrine glands
|
• 12% of mice exhibit fibroadenoma in the mammary gland
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf2tm1Gth mutation
(1 available);
any
Nf2 mutation
(65 available)
Nf2tm2Gth mutation
(3 available);
any
Nf2 mutation
(65 available)
Tg(Mpz-cre)3Brn mutation
(0 available)
|
|
|