All Phenotypes Prnp/Prnd<tm1Dwm> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Prnp/Prnd^tm1Dwm
targeted mutation 1, David W Melton
MGI:3047062

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prnp/Prnd^tm1Dwm/Prnp/Prnd^tm1Dwm	129P2/OlaHsd-Prnp/Prnd^tm1Dwm	MGI:3047566

Allelic Composition	Prnp/Prnd^tm1Dwm/Prnp/Prnd^tm1Dwm
Genetic Background	129P2/OlaHsd-Prnp/Prnd^tm1Dwm

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnp/Prnd^tm1Dwm mutation (0 available); any Prnp mutation (150 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

male infertility ( J:91094 )

• male but not female mutants are infertile

• sperm numbers, morphology and motility are normal

• increased DNA strand breaks and altered chromatin structure are seen in sperm from homozygous mutants

impaired fertilization ( J:91094 )

• no cleaved embryos are recovered 1.5 days after mating of homozygous males to wild-type females

impaired acrosome reaction ( J:91094 )

• acrosome reaction does not increase in response to a calcium ionophore

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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