All Phenotypes Map3k5<tm1Hijo> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Map3k5^tm1Hijo/Map3k5^tm1Hijo	B6.129S4-Map3k5^tm1Hijo	MGI:3046845
hm2	Map3k5^tm1Hijo/Map3k5^tm1Hijo	involves: 129S4/SvJae * C57BL/6J	MGI:3046844
cn3	Map3k5^tm1Hijo/Map3k5^tm1Hijo Raf1^tm2Bacc/Raf1^tm2Bacc Tg(Myh6-cre)2182Mds/0	involves: C57BL/6J	MGI:3510548
cx4	Map3k5^tm1Hijo/Map3k5^tm1Hijo Map3k6^tm1Hijo/Map3k6^tm1Hijo	B6.129-Map3k6^tm1Hijo Map3k5^tm1Hijo	MGI:3844019

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:88195 )

N	• cardiac morphology and function are not different from controls

decreased response of heart to induced stress ( J:88195 )

• 4 weeks after thoracic transverse aortic constriction fractional shortening, left ventricular end diastolic internal dimension, and lung weight are not significantly different from sham operated controls unlike in wild type mice

• decrease in the number of apoptotic cells detected at 1 and 4 weeks after thoracic transverse aortic constriction compared to wild-type controls

• however, 1 week after thoracic transverse aortic constriction heart weight is increased similar to what is seen in wild-type controls and the degree of fibrosis is similar in both mutant and wild-type mice

abnormal response to cardiac infarction ( J:88195 )

• following myocardial infarction increases in left ventricular end diastolic and end systolic internal dimensions are decreased compared to wild-type controls

• following myocardial infarction the decrease in fractional shortening and replacement fibrosis are less than that in wild-type controls

• decrease in the number of apoptotic cells detected at 1 and 4 weeks after induced infarction compared to wild-type controls

homeostasis/metabolism

decreased response of heart to induced stress ( J:88195 )

• decrease in the number of apoptotic cells detected at 1 and 4 weeks after thoracic transverse aortic constriction compared to wild-type controls

abnormal response to cardiac infarction ( J:88195 )

• following myocardial infarction increases in left ventricular end diastolic and end systolic internal dimensions are decreased compared to wild-type controls

• following myocardial infarction the decrease in fractional shortening and replacement fibrosis are less than that in wild-type controls

• decrease in the number of apoptotic cells detected at 1 and 4 weeks after induced infarction compared to wild-type controls

decreased physiological sensitivity to xenobiotic ( J:148044 )

• primary keratinocytes are more resistant to DMBA induced apoptosis compared to wild-type cells

• hyperplasia following TPA exposure is milder than in wild type controls

Allelic Composition	Map3k5^tm1Hijo/Map3k5^tm1Hijo
Genetic Background	involves: 129S4/SvJae * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k5^tm1Hijo mutation (4 available); any Map3k5 mutation (61 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

decreased sensitivity to induced cell death ( J:88612 )

• decrease in the induction of apoptosis by TNF, H2O2 or other oxidative stressors in MEFs

mortality/aging

mortality/aging ( J:251158 )

N	• following treatment with high doses of recombinant mouse TNF (mTNF), mice are only slightly protected from mTNF-induced lethality relative to wild-type controls

immune system

immune system phenotype ( J:251158 )

N	• mice are not significantly protected from TNF (mTNF)-induced mortality and hypothermia

Allelic Composition	Map3k5^tm1Hijo/Map3k5^tm1Hijo Raf1^tm2Bacc/Raf1^tm2Bacc Tg(Myh6-cre)2182Mds/0
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k5^tm1Hijo mutation (4 available); any Map3k5 mutation (61 available)
Raf1^tm2Bacc mutation (0 available); any Raf1 mutation (114 available)
Tg(Myh6-cre)2182Mds mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:93418 )

N	• heart size, morphology and function are not significantly different from wild-type unlike Raf1^tm2Bacc, Tg(Myhca-cre)2182Mds mutants

Allelic Composition	Map3k5^tm1Hijo/Map3k5^tm1Hijo Map3k6^tm1Hijo/Map3k6^tm1Hijo
Genetic Background	B6.129-Map3k6^tm1Hijo Map3k5^tm1Hijo

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k5^tm1Hijo mutation (4 available); any Map3k5 mutation (61 available)
Map3k6^tm1Hijo mutation (3 available); any Map3k6 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:148044 )

• hyperplasia following TPA exposure is milder than in wild type controls or mice homozygous for Map3k6^tm1Hijo alone

neoplasm

neoplasm ( J:148044 )

N	• unlike mice homozygous for Map3k6^tm1Hijo alone, no increase in chemically induced skin tumorigenesis is detected

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23