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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ighatm1(Myc)Janz
targeted mutation 1, Siegfried Janz
MGI:3046399
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Ighatm1(Myc)Janz/Igha+ involves: 129S1/Sv * C57BL/6 MGI:3046402
cx2
Ighatm1(Myc)Janz/Igha+
Tg(Tnfsf13b)1Fma/0
involves: 129S1/Sv * C57BL/6 * DBA/2J MGI:4840220
cx3
Ighatm1(Myc)Janz/Igha+
Tg(Igk-V21-Bax)1967Bvn/0
involves: 129S1/Sv * C57BL/6 * FVB/N MGI:3046405


Genotype
MGI:3046402
ht1
Allelic
Composition
Ighatm1(Myc)Janz/Igha+
Genetic
Background
involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighatm1(Myc)Janz mutation (1 available); any Igha mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• transgenic mice display an increased incidence (9.3%) of B cell derived lymphomas with a mean onset of 330 days

hematopoietic system
• B cell apoptosis is increased about 4.5 fold compared to normal B cells
• B cells proliferate about 2.5 - 3 times faster compared to normal mice
• B220hiCD138+, putative plasmablasts, numbers are increased in the bone marrow of transgenic mice

immune system
• B cell apoptosis is increased about 4.5 fold compared to normal B cells
• B cells proliferate about 2.5 - 3 times faster compared to normal mice
• B220hiCD138+, putative plasmablasts, numbers are increased in the bone marrow of transgenic mice

cellular
• B cell apoptosis is increased about 4.5 fold compared to normal B cells
• B cells proliferate about 2.5 - 3 times faster compared to normal mice




Genotype
MGI:4840220
cx2
Allelic
Composition
Ighatm1(Myc)Janz/Igha+
Tg(Tnfsf13b)1Fma/0
Genetic
Background
involves: 129S1/Sv * C57BL/6 * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighatm1(Myc)Janz mutation (1 available); any Igha mutation (9 available)
Tg(Tnfsf13b)1Fma mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• splenomegaly is obvious in males after 4 months of age

mortality/aging
• median lifespan of mice with leukemia is 10 months

hematopoietic system
• splenomegaly is obvious in males after 4 months of age
• males develop lymphocytosis at 3 months of age
• males exhibit an increase in blood B-cell number, with an expansion of the CD5+CD3-B220low IgMlow B-cell population in blood and spleens
• B-cell increase results from a monoclonal expansion of mature B cell-like cells
• 8 month old spleens of males exhibit enlarged white pulp with loss of normal splenic architecture resulting from a diffuse infiltration of mature lymphocytes

immune system
• splenomegaly is obvious in males after 4 months of age
• males develop lymphocytosis at 3 months of age
• males exhibit an increase in blood B-cell number, with an expansion of the CD5+CD3-B220low IgMlow B-cell population in blood and spleens
• B-cell increase results from a monoclonal expansion of mature B cell-like cells
• 8 month old spleens of males exhibit enlarged white pulp with loss of normal splenic architecture resulting from a diffuse infiltration of mature lymphocytes

neoplasm
• mutants, mainly males, develop a CD5+ B-cell lymphoproliferative disease by 8 months of age that resembles human chronic lymphocytic leukemia
• male mice exhibit increased splenic 18F-labeled 2-fluoro-2-deoxy-D-glucose (FDG) uptake suggesting elevated leukemic cell metabolism




Genotype
MGI:3046405
cx3
Allelic
Composition
Ighatm1(Myc)Janz/Igha+
Tg(Igk-V21-Bax)1967Bvn/0
Genetic
Background
involves: 129S1/Sv * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighatm1(Myc)Janz mutation (1 available); any Igha mutation (9 available)
Tg(Igk-V21-Bax)1967Bvn mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• 8 week old double transgenic exhibit splenomegaly with massive accumulation of plasma cells in extrafollicular areas

mortality/aging
• survival of double transgenics is markedly decreased as a result of malignant plasma cell tumors

neoplasm
• in some cases plasma cell leukemia is seen
• malignant plasma cell tumors develop rapidly with a mean onset of 135 days, are fully penetrant, proliferate vigorously, occur in multiple tissues including the spleen, bone marrow, and lymph nodes, and may have monocentric or multicentric origins
• bone sections from double transgenic mice with less advanced tumors show multifocal lesions of aberrant pleomorphic plasma cells next to diminished of dissolved osseous trabeculae
• pathalogical fractures of the long bones are seen in some double transgenic mice

hematopoietic system
• B cell apoptosis is increased compared to normal B cells but decreased compared to B cells from Igh-2tm1Janz single transgenics
• 8 week old double transgenic exhibit splenomegaly with massive accumulation of plasma cells in extrafollicular areas
• plasma cells participate in cell cycling unlike in normal mice
• the bone marrow and spleen contain on average 42% and 34% plasma cells, respectively, compared to less than 2% in normal mice
• elevation of IgG accompanied the increase in plasma cell numbers
• elevation of IgM accompanied the increase in plasma cell numbers

immune system
• B cell apoptosis is increased compared to normal B cells but decreased compared to B cells from Igh-2tm1Janz single transgenics
• 8 week old double transgenic exhibit splenomegaly with massive accumulation of plasma cells in extrafollicular areas
• plasma cells participate in cell cycling unlike in normal mice
• the bone marrow and spleen contain on average 42% and 34% plasma cells, respectively, compared to less than 2% in normal mice
• elevation of IgG accompanied the increase in plasma cell numbers
• elevation of IgM accompanied the increase in plasma cell numbers

cellular
• B cell apoptosis is increased compared to normal B cells but decreased compared to B cells from Igh-2tm1Janz single transgenics





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last database update
06/23/2022
MGI 6.20
The Jackson Laboratory