Phenotypes associated with this allele
Allelic Composition |
Ighatm1(Myc)Janz/Igha+
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Genetic Background |
involves: 129S1/Sv * C57BL/6 |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighatm1(Myc)Janz mutation
(1 available);
any
Igha mutation
(16 available)
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neoplasm
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• transgenic mice display an increased incidence (9.3%) of B cell derived lymphomas with a mean onset of 330 days
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hematopoietic system
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• B cell apoptosis is increased about 4.5 fold compared to normal B cells
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• B cells proliferate about 2.5 - 3 times faster compared to normal mice
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• B220hiCD138+, putative plasmablasts, numbers are increased in the bone marrow of transgenic mice
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immune system
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• B cell apoptosis is increased about 4.5 fold compared to normal B cells
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• B cells proliferate about 2.5 - 3 times faster compared to normal mice
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• B220hiCD138+, putative plasmablasts, numbers are increased in the bone marrow of transgenic mice
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cellular
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• B cell apoptosis is increased about 4.5 fold compared to normal B cells
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• B cells proliferate about 2.5 - 3 times faster compared to normal mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighatm1(Myc)Janz mutation
(1 available);
any
Igha mutation
(16 available)
Tg(Tnfsf13b)1Fma mutation
(0 available)
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mortality/aging
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• median lifespan of mice with leukemia is 10 months
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hematopoietic system
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• splenomegaly is obvious in males after 4 months of age
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• males develop lymphocytosis at 3 months of age
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• males exhibit an increase in blood B-cell number, with an expansion of the CD5+CD3-B220low IgMlow B-cell population in blood and spleens
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• B-cell increase results from a monoclonal expansion of mature B cell-like cells
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• 8 month old spleens of males exhibit enlarged white pulp with loss of normal splenic architecture resulting from a diffuse infiltration of mature lymphocytes
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immune system
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• splenomegaly is obvious in males after 4 months of age
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• males develop lymphocytosis at 3 months of age
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• males exhibit an increase in blood B-cell number, with an expansion of the CD5+CD3-B220low IgMlow B-cell population in blood and spleens
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• B-cell increase results from a monoclonal expansion of mature B cell-like cells
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• 8 month old spleens of males exhibit enlarged white pulp with loss of normal splenic architecture resulting from a diffuse infiltration of mature lymphocytes
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neoplasm
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• mutants, mainly males, develop a CD5+ B-cell lymphoproliferative disease by 8 months of age that resembles human chronic lymphocytic leukemia
• male mice exhibit increased splenic 18F-labeled 2-fluoro-2-deoxy-D-glucose (FDG) uptake suggesting elevated leukemic cell metabolism
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growth/size/body
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• splenomegaly is obvious in males after 4 months of age
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighatm1(Myc)Janz mutation
(1 available);
any
Igha mutation
(16 available)
Tg(Igk-V21-Bax)1967Bvn mutation
(0 available)
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growth/size/body
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• 8 week old double transgenic exhibit splenomegaly with massive accumulation of plasma cells in extrafollicular areas
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mortality/aging
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• survival of double transgenics is markedly decreased as a result of malignant plasma cell tumors
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neoplasm
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• in some cases plasma cell leukemia is seen
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• malignant plasma cell tumors develop rapidly with a mean onset of 135 days, are fully penetrant, proliferate vigorously, occur in multiple tissues including the spleen, bone marrow, and lymph nodes, and may have monocentric or multicentric origins
• bone sections from double transgenic mice with less advanced tumors show multifocal lesions of aberrant pleomorphic plasma cells next to diminished of dissolved osseous trabeculae
• pathalogical fractures of the long bones are seen in some double transgenic mice
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hematopoietic system
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• B cell apoptosis is increased compared to normal B cells but decreased compared to B cells from Igh-2tm1Janz single transgenics
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• 8 week old double transgenic exhibit splenomegaly with massive accumulation of plasma cells in extrafollicular areas
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• plasma cells participate in cell cycling unlike in normal mice
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• the bone marrow and spleen contain on average 42% and 34% plasma cells, respectively, compared to less than 2% in normal mice
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• elevation of IgG accompanied the increase in plasma cell numbers
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• elevation of IgM accompanied the increase in plasma cell numbers
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immune system
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• B cell apoptosis is increased compared to normal B cells but decreased compared to B cells from Igh-2tm1Janz single transgenics
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• 8 week old double transgenic exhibit splenomegaly with massive accumulation of plasma cells in extrafollicular areas
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• plasma cells participate in cell cycling unlike in normal mice
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• the bone marrow and spleen contain on average 42% and 34% plasma cells, respectively, compared to less than 2% in normal mice
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• elevation of IgG accompanied the increase in plasma cell numbers
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• elevation of IgM accompanied the increase in plasma cell numbers
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cellular
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• B cell apoptosis is increased compared to normal B cells but decreased compared to B cells from Igh-2tm1Janz single transgenics
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