Phenotypes associated with this allele

• Allele Symbol: Cdhr1^tm1Nat
• Allele Name: targeted mutation 1, Jeremy Nathans
• Allele ID: MGI:3046299
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdhr1^tm1Nat/Cdhr1^tm1Nat	either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)	MGI:3046300

Genotype
MGI:3046300

hm1

• Allelic Composition: Cdhr1^tm1Nat/Cdhr1^tm1Nat
• Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal retina morphology ( J:73286 )

• outer segments are thinner, shorter and disorganized

increased susceptibility to age-related retinal degeneration ( J:73286 )

• photoreceptor cell degeneration was detected as early as one month of age and progressed with age; by 6 months of age, a 50% reduction in the number of nuclei in the outer nuclear layer was observed; activation of Muller glia was also noted

abnormal eye electrophysiology ( J:73286 )

• the saturating a-wave amplitude is diminished 2-3 fold and the saturating b-wave amplitude is diminished 2 fold in homozygous mice compared to controls