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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Isl2tm2Slp
targeted mutation 2, Samuel L Pfaff
MGI:3046260
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Isl2tm2Slp/Isl2tm2Slp involves: 129S1/Sv MGI:3046280
cx2
Mnx1tm1Jhk/Mnx1tm1Jhk
Isl2tm2Slp/Isl2tm2Slp
involves: 129P2/OlaHsd * 129S1/Sv MGI:3688256


Genotype
MGI:3046280
hm1
Allelic
Composition
Isl2tm2Slp/Isl2tm2Slp
Genetic
Background
involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl2tm2Slp mutation (1 available); any Isl2 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most homozygotes die within 24 hours of birth

growth/size/body
• severely distended abdomen after birth

nervous system
• bridging between segmentally arrayed motor nerves occurs
• depletion of visceral motor neurons without an increase in somatic motor neurons
• appearance of atypical and ectopic somatic-like neurons
• small nuclei more like visceral than somatic motor neuron nuclei
• early stages of spinal motor neuron differentiation normal
• ectopic localization for some neurons
• tight columnar organization in thoracic region disrupted with intermingling of medial and lateral divisions




Genotype
MGI:3688256
cx2
Allelic
Composition
Mnx1tm1Jhk/Mnx1tm1Jhk
Isl2tm2Slp/Isl2tm2Slp
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl2tm2Slp mutation (1 available); any Isl2 mutation (17 available)
Mnx1tm1Jhk mutation (1 available); any Mnx1 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• frequently observe inappropriate axonal bridges between segmentally arrayed motor nerves indicating defects in motor axon guidance
• exhibit a complete absence of Nos1+ preganglionic motor column neurons
• exhibit motor axon projections into the periphery

cellular
• frequently observe inappropriate axonal bridges between segmentally arrayed motor nerves indicating defects in motor axon guidance





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/04/2022
MGI 6.17
The Jackson Laboratory