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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rhotm3(RHO/GFP)Jhw
targeted mutation 3, John H Wilson
MGI:3046187
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Rhotm3(RHO/GFP)Jhw/Rhotm3(RHO/GFP)Jhw either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S7/SvEvBrd * C57BL/6-Tyrc) MGI:3046198
ht2
Rhotm3(RHO/GFP)Jhw/Rho+ either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S7/SvEvBrd * C57BL/6-Tyrc) MGI:3046199


Genotype
MGI:3046198
hm1
Allelic
Composition
Rhotm3(RHO/GFP)Jhw/Rhotm3(RHO/GFP)Jhw
Genetic
Background
either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S7/SvEvBrd * C57BL/6-Tyrc)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhotm3(RHO/GFP)Jhw mutation (0 available); any Rho mutation (48 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• retinas begin to degenerate within 3-5 months after birth
• retinal degeneration is more severe than in Rhotm2Jhw homozygotes




Genotype
MGI:3046199
ht2
Allelic
Composition
Rhotm3(RHO/GFP)Jhw/Rho+
Genetic
Background
either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S7/SvEvBrd * C57BL/6-Tyrc)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhotm3(RHO/GFP)Jhw mutation (0 available); any Rho mutation (48 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• mild retinal degeneration is seen with the number of nuclei in the outer nuclear layer being reduced to about 80% wild-type





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last database update
04/09/2024
MGI 6.23
The Jackson Laboratory