Mouse Genome Informatics
cn1
    Card11tm1.1Litt/Card11tm1.1Litt
Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+
Tg(TcraTcrb)425Cbn/?

involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• reactivation is prevented after in vitro activation with Ova and tamoxifen treatment

hematopoietic system
• reactivation is prevented after in vitro activation with Ova and tamoxifen treatment


Mouse Genome Informatics
cn2
    Ctcftm1Laat/Ctcftm1Laat
Tg(Lck-cre)1Cwi/0
Tg(TcraTcrb)425Cbn/0

involves: 129P2/OlaHsd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• mice exhibit an almost complete lack of mature T cells in the spleen
• the number of immature single positive cells in the thymus is increased compared to in wild-type mice
• T cell development is more severely arrested than in Ctcftm1Laat/Ctcftm1Laat Tg(Lck-cre)1Cwi mice

hematopoietic system
• mice exhibit an almost complete lack of mature T cells in the spleen
• the number of immature single positive cells in the thymus is increased compared to in wild-type mice
• T cell development is more severely arrested than in Ctcftm1Laat/Ctcftm1Laat Tg(Lck-cre)1Cwi mice


Mouse Genome Informatics
cn3
    Cops5tm1Rpar/Cops5tm1Rpar
Tg(Lck-cre)548Jxm/0
Tg(TcraTcrb)425Cbn/0

involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
hematopoietic system
• an 80-90% reduction compared to control

immune system
• an 80-90% reduction compared to control

endocrine/exocrine glands
• an 80-90% reduction compared to control


Mouse Genome Informatics
cn4
    Foxo1tm1Flv/Foxo1tm1Flv
Rag1tm1Mom/Rag1tm1Mom
Tg(Cd4-cre)1Cwi/?
Tg(TcraTcrb)425Cbn/?

involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• T cell numbers in the spleen and lymph nodes are reduced 80-90% compared to Rag-null OT-II controls

hematopoietic system
• T cell numbers in the spleen and lymph nodes are reduced 80-90% compared to Rag-null OT-II controls


Mouse Genome Informatics
cn5
    Foxo1tm1Flv/Foxo1tm1Flv
Rag1tm1Mom/Rag1tm1Mom
Tg(CD2-Il7r)1Asin/?
Tg(Cd4-cre)1Cwi/?
Tg(TcraTcrb)425Cbn/?

involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• the Il7r transgene rescues the low T cell numbers observed in mice with Foxo1-deficient OT-II T cells

hematopoietic system
• the Il7r transgene rescues the low T cell numbers observed in mice with Foxo1-deficient OT-II T cells


Mouse Genome Informatics
cn6
    Ppp4ctm1Tht/Ppp4ctm1Tht
Tg(Lck-cre)548Jxm/0
Tg(TcraTcrb)425Cbn/0

involves: BALB/c * C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
hematopoietic system
• a significant decrease in unfractionated, double-positive thymocyte numbers compared to single transgenic littermates abnormal CD4 T cell morphology
• significant decrease in SP cell numbers
• only marginal increase in numbers of CD4 positive thymocytes is observed compared to TCR-transgenic mice
• CD4 SP/DP ratio is 0.29 compared to 0.46 in controls, indicating reduced positive selection

immune system
• a significant decrease in unfractionated, double-positive thymocyte numbers compared to single transgenic littermates abnormal CD4 T cell morphology
• significant decrease in SP cell numbers
• only marginal increase in numbers of CD4 positive thymocytes is observed compared to TCR-transgenic mice
• CD4 SP/DP ratio is 0.29 compared to 0.46 in controls, indicating reduced positive selection


Mouse Genome Informatics
cn7
    Tg(Cd4-cre)1Cwi/?
Tg(TcraTcrb)425Cbn/?
Traf6tm2Ywc/Traf6tm2Ywc

involves: C57BL/6 * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• CD4 T cells from mice immunized with OVA antigen secrete almost 10-fold more IL-2 upon in vitro antigen restimulate compared to mice transgenic only for the T cell receptor
• OVA antigen specific T cells continue to proliferate upon antigen restimulation in a transfer model of tolerance


Mouse Genome Informatics
cx8
    Cd84tm1Pls/Cd84tm1Pls
Tg(TcraTcrb)425Cbn/?

B6.Cg-Cd84tm1Pls Tg(TcraTcrb)425Cbn
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• when B cells are used as the antigen presenting cells, T cells are significantly less efficient in forming conjugates as compared to their wild-type counterparts

hematopoietic system
• when B cells are used as the antigen presenting cells, T cells are significantly less efficient in forming conjugates as compared to their wild-type counterparts


Mouse Genome Informatics
cx9
    Tespa1tm1Lrgl/Tespa1tm1Lrgl
Tg(TcraTcrb)425Cbn/0

B6.Cg-Tespa1tm1Lrgl Tg(TcraTcrb)425Cbn
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• very few cells proceed to the CD4+ single positive stage

hematopoietic system
• very few cells proceed to the CD4+ single positive stage


Mouse Genome Informatics
cx10
    Tg(TcraTcrb)425Cbn/0
Trip10tm1.1Geha/Trip10tm1.1Geha

B6.Cg-Trip10tm1.1Geha Tg(TcraTcrb)425Cbn
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
N
• oxazalone-treated mice exhibit normal antigen-specific T effector cell generation (J:164363)
• following ovalbumin skin-challenge, effector T cells exhibit a 10-fold reduction in accumulation compared to when wild-type cells are transferred
• accumulation of CD4+ T cells in ovalbumin-challenged ears of wild-type recipient mice is impaired compared to when wild-type cells are used

hematopoietic system
• following ovalbumin skin-challenge, effector T cells exhibit a 10-fold reduction in accumulation compared to when wild-type cells are transferred
• accumulation of CD4+ T cells in ovalbumin-challenged ears of wild-type recipient mice is impaired compared to when wild-type cells are used


Mouse Genome Informatics
cx11
    Rnf128tm1Cdon/Rnf128tm1Cdon
Tg(TcraTcrb)425Cbn/0

involves: 129 * BALB/c * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
hematopoietic system
• V alpha 2, CD44+ CD4+ T cells from ovalbumin primed mice when stimulated in culture fail to exhibit a reduced immune response (J:160681)

immune system
• V alpha 2, CD44+ CD4+ T cells from ovalbumin primed mice when stimulated in culture fail to exhibit a reduced immune response (J:160681)
• V alpha 2, CD44+ CD4+ T cells from ovalbumin primed mice when stimulated in culture fail to exhibit a reduced immune response (J:160681)
• V alpha 2, CD44+ CD4+ T cells from ovalbumin primed mice when stimulated in culture fail to exhibit a reduced immune response (J:160681)
• abnormal antigen-specific CD4+ T cell tolerance (J:160681)

cellular
• V alpha 2, CD44+ CD4+ T cells from ovalbumin primed mice when stimulated in culture fail to exhibit a reduced immune response (J:160681)


Mouse Genome Informatics
cx12
    Elk4tm1Rtr/Elk4tm1Rtr
Tg(TcraTcrb)425Cbn/?

involves: 129/Sv * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
hematopoietic system
• mutants generate about 75% fewer CD4+ single-positive thymocytes than wild-type
• CD4 thymocyte positive selection is impaired; mutants generate about 75% fewer CD4+ single-positive thymocytes than wild-type
• decrease in splenic CD4:CD8 ratio

immune system
• mutants generate about 75% fewer CD4+ single-positive thymocytes than wild-type
• CD4 thymocyte positive selection is impaired; mutants generate about 75% fewer CD4+ single-positive thymocytes than wild-type
• decrease in splenic CD4:CD8 ratio


Mouse Genome Informatics
cx13
    Rhohtm1Brak/Rhohtm1Brak
Tg(TcraTcrb)425Cbn/?

involves: 129/Sv * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
N
• no increase in DN4 cells observed (J:143161)
• severely impaired generation of CD4+ cells

hematopoietic system
• severely impaired generation of CD4+ cells


Mouse Genome Informatics
cx14
    Gpr15tm1.1Litt/Gpr15tm1.1Litt
Rag2tm1Fwa/Rag2tm1Fwa
Tg(TcraTcrb)425Cbn/0

involves: 129P2/OlaHsd * 129S/SvEv * BALB/c * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• mice fed chicken ovalbumin exhibit a reduced increase the number and frequency of regulatory T cells in the large intestine lamina propria comparted with control mice


Mouse Genome Informatics
cx15
    Ndfip1Gt(RRD002)Byg/Ndfip1Gt(RRD002)Byg
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraTcrb)425Cbn/0

involves: 129P2/OlaHsd * 129S7/SvEvBrd * BALB/c * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
N
• unlike Ndfip1Gt(RRD002)Byg homozygotes, mice do not develop eosinophilic inflammation and T cells do not acquire an activated phenotype in the absence of antigen (J:205692)


Mouse Genome Informatics
cx16
    Tg(TcraTcrb)425Cbn/0
Trim30atm1Yjk/Trim30atm1Yjk

involves: 129P2/OlaHsd * BALB/c * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• T cells exhibit 10-20% enhanced proliferation compared to single Tg(TcraTcrb)425Cbn T cells, particularly when stimulated with a low dose of OVA(323-339) peptide

hematopoietic system
• T cells exhibit 10-20% enhanced proliferation compared to single Tg(TcraTcrb)425Cbn T cells, particularly when stimulated with a low dose of OVA(323-339) peptide


Mouse Genome Informatics
cx17
    Tg(Ins2-TFRC/OVA)296Wehi/0
Tg(TcraTcrb)425Cbn/0

involves: 129P2/OlaHsd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• there is a 10 fold drop in the number of CD4 single positive thymocytes in the thymus compared to controls due to increased negative selection of T cell bearing the transgenic TCR
• the number of CD4 T cells in the periphery that express the gene segments associated with the transgenic TCR is reduced almost by half compared to mice carrying just the Tg(TcraTcrb)425Cbn OT-II transgene
• the percentage of double-positive T cells in the thymus is increased by 20 % compared to control mice

hematopoietic system
• there is a 10 fold drop in the number of CD4 single positive thymocytes in the thymus compared to controls due to increased negative selection of T cell bearing the transgenic TCR
• the number of CD4 T cells in the periphery that express the gene segments associated with the transgenic TCR is reduced almost by half compared to mice carrying just the Tg(TcraTcrb)425Cbn OT-II transgene
• the percentage of double-positive T cells in the thymus is increased by 20 % compared to control mice


Mouse Genome Informatics
cx18
    Airetm1Mand/Aire+
Tg(Ins2-TFRC/OVA)296Wehi/0
Tg(TcraTcrb)425Cbn/0

involves: 129P2/OlaHsd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• negative selection fails to occur of CD 4 T cells bearing the transgenic TCR as evidenced by the normal number of clonotypic T cells found in the thymus and spleen

hematopoietic system
• negative selection fails to occur of CD 4 T cells bearing the transgenic TCR as evidenced by the normal number of clonotypic T cells found in the thymus and spleen


Mouse Genome Informatics
cx19
    Airetm1.1Doi/Airetm1.1Doi
Tg(Ins2-TFRC/OVA)296Wehi/0
Tg(TcraTcrb)425Cbn/0

involves: 129P2/OlaHsd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• there is a slight reduction in the number of CD4 single positive thymocytes in the thymus compared to controls
• negative selection of CD 4 T cells bearing the transgenic TCR is impaired as evidenced by only a slight reduction of clonotypic T cells occuring in the thymus and spleen

hematopoietic system
• there is a slight reduction in the number of CD4 single positive thymocytes in the thymus compared to controls
• negative selection of CD 4 T cells bearing the transgenic TCR is impaired as evidenced by only a slight reduction of clonotypic T cells occuring in the thymus and spleen


Mouse Genome Informatics
cx20
    Git2Gt(XG510)Byg/Git2Gt(XG510)Byg
Tg(TcraTcrb)425Cbn/0

involves: 129P2/OlaHsd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
hematopoietic system
• single positive cell number in thymus
• transgene positive CD4 cells in spleen, lymph node and blood

immune system
• single positive cell number in thymus
• transgene positive CD4 cells in spleen, lymph node and blood


Mouse Genome Informatics
cx21
    Mcl1tm1Yen/Mcl1tm1Yen
Tg(TcraTcrb)425Cbn/?

involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• mice have decreased frequency and numbers of transgenic CD4+ T cells in the thymus and in the periphery
• mice have decreased numbers of double positive thymocytes expressing the transgenic TCR

hematopoietic system
• mice have decreased frequency and numbers of transgenic CD4+ T cells in the thymus and in the periphery
• mice have decreased numbers of double positive thymocytes expressing the transgenic TCR


Mouse Genome Informatics
cx22
    Icostm1Flv/Icostm1Flv
Tg(TcraTcrb)425Cbn/0

involves: 129S1/Sv * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• naive CD4 T cells cultured with OVA peptide-loaded wild-type splenic antigen presenting cells (APCs) and restimulated with anti-CD3 and secrete less IL-4 and IL-17a and more interferon gamma (Ifng) than stimulated wild-type CD4 T cells
• CD4 T cells cultured with OVA peptide-loaded spleen cells from B7 (CD80/86) deficient mice then restimulated with anti-CD3 do not produce IL-4, IL-17a or Ifng


Mouse Genome Informatics
cx23
    Rnf128tm1.1Flv/Rnf128tm1.1Flv
Tg(TcraTcrb)425Cbn/0

involves: 129S6/SvEvTac * BALB/c * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• despite increasing antigen doses, CD4+ T cells cannot be tolerized unlike similarly treated wild-type cells and continue to exhibit increased T cell proliferation and IL2 production (J:153216)

homeostasis/metabolism

hematopoietic system


Mouse Genome Informatics
cx24
    Rnf128tm1.1Flv/Y
Tg(TcraTcrb)425Cbn/0

involves: 129S6/SvEvTac * BALB/c * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• despite increasing antigen doses, CD4+ T cells cannot be tolerized unlike similarly treated wild-type cells and continue to exhibit increased T cell proliferation and IL2 production (J:153216)

homeostasis/metabolism

hematopoietic system


Mouse Genome Informatics
cx25
    H2-T23tm3Cant/H2-T23tm3Cant
Tg(TcraTcrb)425Cbn/?

involves: 129S6/SvEvTac * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• cells are resistant to CD8 T regulatory cells when co-transferred into an immunodeficient host

hematopoietic system
• cells are resistant to CD8 T regulatory cells when co-transferred into an immunodeficient host


Mouse Genome Informatics
cx26
    Sh2d1atm1Pls/Sh2d1atm1Pls
Tg(TcraTcrb)425Cbn/?

involves: 129S6/SvEvTac * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• T cell to B cell antigen specific, dose dependent conjugate formation is maintained for 10 min but not for 30 min (J:157915)

hematopoietic system
• T cell to B cell antigen specific, dose dependent conjugate formation is maintained for 10 min but not for 30 min (J:157915)


Mouse Genome Informatics
cx27
    Tg(CD2-Caecam1*4L)1Rsb/0
Tg(TcraTcrb)425Cbn/0

involves: BALB/c * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• CD4+ spleen cells exhibit decreased proliferation and IL-2 production in response to OVA (ovalbumin) and OVA peptide compared to Tg(TcraTcrb)425Cbn mice

hematopoietic system
• CD4+ spleen cells exhibit decreased proliferation and IL-2 production in response to OVA (ovalbumin) and OVA peptide compared to Tg(TcraTcrb)425Cbn mice


Mouse Genome Informatics
cx28
    Ptprctm1Mak/Ptprctm1Mak
Tg(TcraTcrb)425Cbn/0

involves: BALB/c * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system

hematopoietic system


Mouse Genome Informatics
cx29
    Ptprcltng/Ptprctm1Mak
Tg(TcraTcrb)425Cbn/0

involves: BALB/c * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• fewer Tg(TcraTcrb)425Cbn CD4+ T cells develop compared to in wild-type Tg(TcraTcrb)425Cbn mice

hematopoietic system
• fewer Tg(TcraTcrb)425Cbn CD4+ T cells develop compared to in wild-type Tg(TcraTcrb)425Cbn mice

endocrine/exocrine glands


Mouse Genome Informatics
cx30
    Plxna1tm1Kik/Plxna1tm1Kik
Tg(TcraTcrb)425Cbn/?

involves: BALB/c * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• ova induced proliferative response is much reduced

hematopoietic system
• ova induced proliferative response is much reduced


Mouse Genome Informatics
cx31
    Pip5k1ctm1.2Ref/Pip5k1ctm1.2Ref
Tg(TcraTcrb)425Cbn/0

involves: BALB/c * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• adhesion to ICAM-1 is increased compared to in wild-type cells
• T cell-APC conjugate formation is decreased compared to in wild-type cells
• CD4+ T cells exhibit increased proliferation in vitro and in vivo compared with similarly treated wild-type cells
• following activation with ovalbumin peptide and restimulation with anti-CD3 and anti-CD28 antibodies
• following activation with ovalbumin peptide and restimulation with anti-CD3 and anti-CD28 antibodies

hematopoietic system
• adhesion to ICAM-1 is increased compared to in wild-type cells
• T cell-APC conjugate formation is decreased compared to in wild-type cells
• CD4+ T cells exhibit increased proliferation in vitro and in vivo compared with similarly treated wild-type cells


Mouse Genome Informatics
cx32
    Ptpn22tm1.1Kas/Ptpn22tm1.1Kas
Tg(TcraTcrb)425Cbn/0

involves: BALB/c * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• mice exhibit increased positive selection of thymic and peripheral T cells compared with wild-type mice
• in naive spleen and lymph node in response to TCR stimulation and enhanced and prolonged Lck and ZAP-70 tyrosine phosphorylation

hematopoietic system
• mice exhibit increased positive selection of thymic and peripheral T cells compared with wild-type mice
• in naive spleen and lymph node in response to TCR stimulation and enhanced and prolonged Lck and ZAP-70 tyrosine phosphorylation


Mouse Genome Informatics
cx33
    Airetm1Mmat/Airetm2Mmat
Tg(TcraTcrb)425Cbn/?

involves: BALB/c * C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
N
• autoimmune pathology is absent unlike in mice not carrying Tg(TcraTcrb)425Cbn (J:141379)
• GFP expressing cells are less complex in shape compared to GFP expressing cells in mice with one wild type allele
• distribution of GFP expressing cells is altered similar to mice homozygous for Airetm2Mmat

hematopoietic system
• GFP expressing cells are less complex in shape compared to GFP expressing cells in mice with one wild type allele
• distribution of GFP expressing cells is altered similar to mice homozygous for Airetm2Mmat

endocrine/exocrine glands
• GFP expressing cells are less complex in shape compared to GFP expressing cells in mice with one wild type allele
• distribution of GFP expressing cells is altered similar to mice homozygous for Airetm2Mmat


Mouse Genome Informatics
cx34
    Bcl6tm1.1Toka/Bcl6+
Tg(TcraTcrb)425Cbn/0

involves: BALB/c * C57BL/6 * NZB
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• T follicular helper cells in mice immunized with NP-ovalbumin exhibit accelerated proliferatively quiescent unlike wild-type cells

hematopoietic system
• T follicular helper cells in mice immunized with NP-ovalbumin exhibit accelerated proliferatively quiescent unlike wild-type cells


Mouse Genome Informatics
cx35
    Lcktm1Dbs/Lcktm1Dbs
Tg(TcraTcrb)425Cbn/0

involves: C3H * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
hematopoietic system
• positive selection of CD4 and CD8 lineage is compromised
• almost complete block of positive selection is observed

immune system
• positive selection of CD4 and CD8 lineage is compromised
• almost complete block of positive selection is observed


Mouse Genome Informatics
cx36
    Tg(CD2-Mir181d)38Oers/0
Tg(TcraTcrb)425Cbn/0

involves: C3H * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
hematopoietic system
• dramatic reduction in the periphery

immune system
• dramatic reduction in the periphery


Mouse Genome Informatics
cx37
    Btlatm1Dgra/Btlatm1Dgra
Tg(TcraTcrb)425Cbn/?

involves: C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• T cells are resistant to tolerance induced by peptide injections
• T cells from mutant mice pre-treated with OVA produce higher levels of IL-2 and IFN-gamma, and proliferate more vigorously in response to OVA restimulation than do controls
• IFN-gamma production is higher for T cells from mutant mice pre-treated with OVA compared to mutant mice pre-treated with PBS


Mouse Genome Informatics
cx38
    Patz1tm1.1Welm/Patz1tm1.1Welm
Tg(TcraTcrb)425Cbn/0

involves: C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
hematopoietic system
• slightly higher percentage of CD4+ T cells and correspondingly lower frequency of CD8+ T

immune system
• slightly higher percentage of CD4+ T cells and correspondingly lower frequency of CD8+ T


Mouse Genome Informatics
cx39
    Foxp3tm1.1Ayr/Y
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraTcrb)425Cbn/0

Not Specified
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
N
• mice exhibit no differences in thymocyte and peripheral T cell subpopulations and normal antigen sensitivity, costimulation requirement and proliferative capacity of nonregulatory CD4+ T cells (J:97029)

normal phenotype
• mice were healthy and phenotypically indistinguishable from controls (J:97029)


Mouse Genome Informatics
tg40
    Tg(TcraTcrb)425Cbn/0
involves: BALB/c * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
hematopoietic system
• positive selection of CD4+ T cells is significantly greater in the thymus compared to Tg(Tcra51-11.5,Tcrb51-11.5)AR206Ayr mice

immune system
• positive selection of CD4+ T cells is significantly greater in the thymus compared to Tg(Tcra51-11.5,Tcrb51-11.5)AR206Ayr mice


Mouse Genome Informatics
tg41
    Tg(TcraTcrb)425Cbn/0
involves: C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• CD4 T cells cultured with OVA peptide-loaded spleen cells from B7 (CD80/86) deficient mice then restimulated with anti-CD3 produce lower amounts of IL-4, Il-17a, and interferon gamma (Ifng) than wild-type T cells

homeostasis/metabolism
• CD4 T cells cultured with OVA peptide-loaded spleen cells from B7 (CD80/86) deficient mice then restimulated with anti-CD3 produce lower amounts of IL-4, Il-17a, and interferon gamma (Ifng) than wild-type T cells


Mouse Genome Informatics
tg42
    Tg(TcraTcrb)425Cbn/?
involves: BALB/c * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• cells from thymus and lymph nodes exhibit a fourfold increase in CD4 to CD8 peripheral T cell ratios as compared to non-transgenic control
• positive selection of CD4+ T cells is significantly greater in the thymus and lymph nodes compared to non-transgenic contro

hematopoietic system
• cells from thymus and lymph nodes exhibit a fourfold increase in CD4 to CD8 peripheral T cell ratios as compared to non-transgenic control
• positive selection of CD4+ T cells is significantly greater in the thymus and lymph nodes compared to non-transgenic contro