About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		MybPlt4
Plt4
MGI:3045843
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Mpltm1Wsa/Mpltm1Wsa
MybPlt4/MybPlt4 		involves: 129S1/Sv * C57BL/6 MGI:3045897
cx2
 		Mpltm1Wsa/Mpltm1Wsa
MybPlt4/Myb+ 		involves: 129S1/Sv * C57BL/6 MGI:3045898


Genotype
MGI:3045897
cx1
Allelic
Composition		 Mpltm1Wsa/Mpltm1Wsa
MybPlt4/MybPlt4
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mpltm1Wsa mutation (1 available); any Mpl mutation (46 available)
MybPlt4 mutation (0 available); any Myb mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal megakaryocyte differentiation ( J:89601 )
• increased numbers of progenitor cells and megakaryocytes in both bone marrow and in spleen
abnormal definitive hematopoiesis ( J:89601 )
• numbers of most progenitor cell lines are elevated
abnormal erythropoiesis ( J:89601 )
• defective production of erythroid lineages
• large numbers of erythroid colony forming units but defective maturation
thrombocytosis ( J:89601 )
• supraphysiological levels
decreased leukocyte cell number ( J:89601 )
• leukopenic
• significantly reduced numbers of B cells in bone marrow and spleen
increased spleen red pulp amount ( J:89601 )
• expanded red pulp with abnormal architecture
decreased spleen B cell follicle size ( J:89601 )
• abnormally small lymphoid follicles

immune system
decreased leukocyte cell number ( J:89601 )
• leukopenic
• significantly reduced numbers of B cells in bone marrow and spleen
increased spleen red pulp amount ( J:89601 )
• expanded red pulp with abnormal architecture
decreased spleen B cell follicle size ( J:89601 )
• abnormally small lymphoid follicles

cellular
abnormal megakaryocyte differentiation ( J:89601 )
• increased numbers of progenitor cells and megakaryocytes in both bone marrow and in spleen




Genotype
MGI:3045898
cx2
Allelic
Composition		 Mpltm1Wsa/Mpltm1Wsa
MybPlt4/Myb+
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mpltm1Wsa mutation (1 available); any Mpl mutation (46 available)
MybPlt4 mutation (0 available); any Myb mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal megakaryocyte differentiation ( J:89601 )
• increased numbers of progenitor cells and megakaryocytes in both bone marrow and in spleen
abnormal definitive hematopoiesis ( J:89601 )
• numbers of most progenitor cell lines are unchanged
thrombocytosis ( J:89601 )
• amelioration of thrombocytopenia compared to Mpltm1Wsa but not to wild-type

cellular
abnormal megakaryocyte differentiation ( J:89601 )
• increased numbers of progenitor cells and megakaryocytes in both bone marrow and in spleen

immune system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory