All Phenotypes Tgfbr2<tm1Roes> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cd19^tm1(cre)Cgn/Cd19⁺ Tgfbr2^tm1Roes/Tgfbr2^tm1Roes	involves: 129P2/OlaHsd * BALB/c	MGI:3051965
cn2	Mob1a^tm1.1Asuz/Mob1a^tm1.1Asuz Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi} Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Tgfbr2^tm1Roes/Tgfbr2^tm1Roes	involves: 129P2/OlaHsd * C57BL/6 * DBA	MGI:5897816
cn3	Dct^tm1(cre)Bee/Dct^tm1(cre)Bee Tgfbr2^tm1Roes/Tgfbr2^tm1Roes Tg(Dct-lacZ)A12Jkn/0	involves: 129/Sv * C57BL/6 * C57BL/6J * CBA	MGI:6241339

Allelic Composition	Cd19^tm1(cre)Cgn/Cd19⁺ Tgfbr2^tm1Roes/Tgfbr2^tm1Roes
Genetic Background	involves: 129P2/OlaHsd * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (11 available); any Cd19 mutation (56 available)
Tgfbr2^tm1Roes mutation (2 available); any Tgfbr2 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

absent plasma cells ( J:90558 )

• IgA expressing plasma cells are virtually absent from the spleen and bone marrow of mutants

increased leukocyte cell number ( J:90558 )

• a 3 fold increase in leukocyte numbers is seen

abnormal B-1 B cell morphology ( J:90558 )

abnormal B-1 B cell number ( J:90558 )

• increased proliferation of mature splenic B cells is seen, however a decrease in B-1 cell proliferation and increase in B-1 cell survival time are also seen

abnormal B cell physiology ( J:90558 )

• more activated B cells are found in mutants

• sera from 9 week or 8 month old mutants shows increased binding to double stranded DNA indicating impaired control of B cell activation

decreased IgA level ( J:90558 )

• serum IgA levels are reduced by about 10 fold and are not increased in response to antigens

increased IgG level ( J:90558 )

• serum levels of all IgG subclasses are increased with IgG1 showing the largest increase (16 fold)

• IgG3 antigen-induced expression is greatly increased

increased IgM level ( J:90558 )

• serum IgM levels and IgM expression by peripheral B cells are increased

immune system

absent plasma cells ( J:90558 )

• IgA expressing plasma cells are virtually absent from the spleen and bone marrow of mutants

increased leukocyte cell number ( J:90558 )

• a 3 fold increase in leukocyte numbers is seen

abnormal B-1 B cell morphology ( J:90558 )

abnormal B-1 B cell number ( J:90558 )

• increased proliferation of mature splenic B cells is seen, however a decrease in B-1 cell proliferation and increase in B-1 cell survival time are also seen

abnormal B cell physiology ( J:90558 )

• more activated B cells are found in mutants

• sera from 9 week or 8 month old mutants shows increased binding to double stranded DNA indicating impaired control of B cell activation

decreased IgA level ( J:90558 )

• serum IgA levels are reduced by about 10 fold and are not increased in response to antigens

increased IgG level ( J:90558 )

• serum levels of all IgG subclasses are increased with IgG1 showing the largest increase (16 fold)

• IgG3 antigen-induced expression is greatly increased

increased IgM level ( J:90558 )

• serum IgM levels and IgM expression by peripheral B cells are increased

enlarged Peyer's patches ( J:90558 )

• Peyer's patches are larger and more distinct

Allelic Composition	Mob1a^tm1.1Asuz/Mob1a^tm1.1Asuz Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi} Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Tgfbr2^tm1Roes/Tgfbr2^tm1Roes
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mob1a^tm1.1Asuz mutation (0 available); any Mob1a mutation (18 available)
Mob1b^{Gt(CC0690)Wtsi} mutation (0 available); any Mob1b mutation (21 available)
Speer6-ps1^{Tg(Alb-cre)21Mgn} mutation (6 available); any Speer6-ps1 mutation (4 available)
Tgfbr2^tm1Roes mutation (2 available); any Tgfbr2 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

abnormal cholangiocyte morphology ( J:228499 )

• increased immature cholangiocyte-like and oval cells but not as much as in Mob1a^tm1.1Asuz/Mob1a^tm1.1Asuz Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi} Tg(Alb-cre)21Mgn mice

increased liver weight ( J:228499 )

• not as much as in Mob1a^tm1.1Asuz/Mob1a^tm1.1Asuz Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi} Tg(Alb-cre)21Mgn mice

liver fibrosis ( J:228499 )

• not as much as in Mob1a^tm1.1Asuz/Mob1a^tm1.1Asuz Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi} Tg(Alb-cre)21Mgn mice

endocrine/exocrine glands

abnormal cholangiocyte morphology ( J:228499 )

• increased immature cholangiocyte-like and oval cells but not as much as in Mob1a^tm1.1Asuz/Mob1a^tm1.1Asuz Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi} Tg(Alb-cre)21Mgn mice

growth/size/body

increased liver weight ( J:228499 )

• not as much as in Mob1a^tm1.1Asuz/Mob1a^tm1.1Asuz Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi} Tg(Alb-cre)21Mgn mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:157070 )

• 73.3% of mice exhibit mild but accelerated hair graying within 10 months after birth relative to control mice; the frequency of gray hairs is variable depending on the individual mouse

• hair graying is likely caused by incomplete maintenance of melanocyte stem cells

abnormal hair follicle melanocyte morphology ( J:157070 )

• late anagen follicles exhibit LacZ+ dendritic and slightly pigmented melanocytes with large cell bodies in the bulge-subbulge area; in contrast, LacZ+ melanoblasts in the bulge area of control follicles are immature and small with minimal dendrites, typical features of melanocyte stem cells

• at 6 months of age, the frequency of hair follicles with large and dendritic melanocytes or pigmented melanocytes in the bulge area of anagen IV-VI follicles is significantly higher than that in control follicles

• some follicles show complete loss of Dct-lacZ+ cells in the bulge area, suggesting that melanocyte stem cells have prematurely differentiated and are eventually depleted from the stem cell niche

• melanocyte stem cells are lost in the bulge area of almost all follicles that produce white hair

• in contrast, the distribution of epidermal and dermal melanocytes in the pigmented junctional epithelium is normal

ectopic hair follicle melanin granules ( J:157070 )

• mice exhibit deposition of melanin pigment in the bulge area of midanagen hair follicles

pigment incontinence ( J:157070 )

• melanin incontinence in the dermal papillae of hair follicles occurs more frequently than in control follicles

ectopic melanocytes ( J:157070 )

• midanagen hair follicles begin to show ectopically pigmented melanocytes with dendritic morphologies starting from the second hair cycle

• ectopically differentiated melanocytes are preferentially seen in follicles that show pigmentation defects in the hair matrix

integument

abnormal coat/hair pigmentation ( J:157070 )

• 73.3% of mice exhibit mild but accelerated hair graying within 10 months after birth relative to control mice; the frequency of gray hairs is variable depending on the individual mouse

• hair graying is likely caused by incomplete maintenance of melanocyte stem cells

abnormal hair follicle melanocyte morphology ( J:157070 )

• some follicles show complete loss of Dct-lacZ+ cells in the bulge area, suggesting that melanocyte stem cells have prematurely differentiated and are eventually depleted from the stem cell niche

• melanocyte stem cells are lost in the bulge area of almost all follicles that produce white hair

• in contrast, the distribution of epidermal and dermal melanocytes in the pigmented junctional epithelium is normal

ectopic hair follicle melanin granules ( J:157070 )

• mice exhibit deposition of melanin pigment in the bulge area of midanagen hair follicles

pigment incontinence ( J:157070 )

• melanin incontinence in the dermal papillae of hair follicles occurs more frequently than in control follicles

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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