Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr7tm1Aki mutation
(3 available);
any
Tlr7 mutation
(21 available)
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immune system
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• following infection with attenuated yellow fever vaccine 17D (YF-17D), dendritic cells produce less IL-12p40 relative to wild-type mice
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• following infection with attenuated yellow fever vaccine 17D (YF-17D), dendritic cells produce less IL-12p40 relative to wild-type mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr7tm1Aki mutation
(3 available);
any
Tlr7 mutation
(21 available)
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immune system
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• bone marrow-derived plasmacytoid dendritic cells infected with a low dose of murine hepatitis virus A59 are not able to produce IFN-alpha compared to wild-type mice that show IFN-alpha production
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr7tm1Aki mutation
(3 available);
any
Tlr7 mutation
(21 available)
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hematopoietic system
N |
• serum levels of IgM and IgG3 are comparable to wild-type levels at 8 weeks of age
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immune system
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• 20% monocytosis incidence in males
• monocytosis incidence is decreased compared to C57BL/6-Nba2NZB Yaa males (71% incidence)
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• increased production of retroviral gp70 immune complex compared to wild-type males
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• 25% incidence of lethal lupus nephritis in males by 14 months of age
• decreased susceptibility to lupus nephritis and decreased glomerular lesion scores compared to C57BL/6-Nba2 Yaa males
• increased glomerular lesion score compared to wild-type males
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renal/urinary system
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• 25% incidence of lethal lupus nephritis in males by 14 months of age
• decreased susceptibility to lupus nephritis and decreased glomerular lesion scores compared to C57BL/6-Nba2 Yaa males
• increased glomerular lesion score compared to wild-type males
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hematopoietic system
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• 20% monocytosis incidence in males
• monocytosis incidence is decreased compared to C57BL/6-Nba2NZB Yaa males (71% incidence)
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immune system
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• bone marrow-derived plasmacytoid dendritic cells infected with a low dose of murine hepatitis virus A59 are not able to produce IFN-alpha compared to wild-type mice that show IFN-alpha production
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immune system
N |
• unlike in Smcr8em1Btlr homozygotes, spleen and lymph nodes are restored to normal as well as is the hyperactivation of T cells and increased circulating IL12p40 levels
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mortality/aging
N |
• unlike Unc93b1tm1.1Kmiy homozygotes, mice do not exhibit premature death
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hematopoietic system
N |
• unlike Unc93b1tm1.1Kmiy homozygotes, mice do not exhibit expansion of erythroblasts and myeloid cells in the spleen
• unlike Unc93b1tm1.1Kmiy homozygotes, mice exhibit normal platelet counts, memory T cells, and B cell maturation and expansion
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