Phenotypes associated with this allele

• Allele Symbol: Sstr2^tm1Pce
• Allele Name: targeted mutation 1, Piers C Emson
• Allele ID: MGI:3045430
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sstr2^tm1Pce/Sstr2^tm1Pce	B6.129P2-Sstr2^tm1Pce	MGI:3759486
hm2	Sstr2^tm1Pce/Sstr2^tm1Pce	involves: 129P2/OlaHsd * C57BL/6	MGI:3759487
hm3	Sstr2^tm1Pce/Sstr2^tm1Pce	involves: 129S4/SvJae	MGI:3716348

Genotype
MGI:3759486

hm1

• Allelic Composition: Sstr2^tm1Pce/Sstr2^tm1Pce
• Genetic Background: B6.129P2-Sstr2^tm1Pce

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal retina rod bipolar cell morphology ( J:89799 )

• at postnatal day 14 and in adult mice, enlargements at the tips of the rod bipolar cells are 13+/-6% and 14+/-2% smaller, respectively, than in wild-type mice

abnormal synaptic glutamate release ( J:89708 )

• basal glutamate levels are elevated (2015+/-597 mM compared to 913+/-216 nM in with type mice)

• somatostatin-induced glutamate release is attenuated (114+/-5% compared to 297+/-84% in wild-type mice

behavior/neurological

abnormal behavior ( J:89708 )

• mice are calmer than wild-type mice when handled

impaired coordination ( J:89708 )

• when tested on a narrow beam (8 mm, round) mice do not regain their balance once it is lost as wild-type mice do and drag themselves across the beam with forelimbs

• however, mice exhibit normal basal motor activity and coordination in other tests

vision/eye

abnormal retina rod bipolar cell morphology ( J:89799 )

• at postnatal day 14 and in adult mice, enlargements at the tips of the rod bipolar cells are 13+/-6% and 14+/-2% smaller, respectively, than in wild-type mice

cardiovascular system

decreased myocardial infarct size ( J:96802 )

• in both a transient and permanent middle cerebral artery occlusion (MCAO) model of ischemic injury, infarct size is reduced 63% 3 days after transient MCAO and 40% 7 days after permanent MCAO compared to in similarly treated wild-type mice

homeostasis/metabolism

decreased myocardial infarct size ( J:96802 )

• in both a transient and permanent middle cerebral artery occlusion (MCAO) model of ischemic injury, infarct size is reduced 63% 3 days after transient MCAO and 40% 7 days after permanent MCAO compared to in similarly treated wild-type mice

decreased dopamine level ( J:89708 )

• while basal levels are normal, somatostatin-induced release of dopamine is attenuated (115+/-34% compared to 248+/-43% in wild-type mice)

Genotype
MGI:3759487

hm2

• Allelic Composition: Sstr2^tm1Pce/Sstr2^tm1Pce
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

nervous system

abnormal brain wave pattern ( J:101285 )

• spontaneous bursting recorded in the hippocampal CA3 region is reduced 9% (24.7+/-0.3 per minute compared to 27.4+/-0.2 per minute in wild-type mice)

• unlike in wild-type mice, epileptiform activity is worsened by D-Tyr⁸ Cyn 154806

• however, response to SRIF is the same as in wild-type mice

Genotype
MGI:3716348

hm3

• Allelic Composition: Sstr2^tm1Pce/Sstr2^tm1Pce
• Genetic Background: involves: 129S4/SvJae

vision/eye

vision/eye phenotype ( J:122896 )

N • apoptotic cell death in outer and inner nuclear, and granule cell layers is not different from wild-type when retinas are incubated in ischemic solution for 1, 3, or 6 hours

N • dopaminergic amacrine cells are not damaged by ischemia

abnormal retina rod bipolar cell morphology ( J:122896 )

• rod bipolar cells from null mice show significantly more damage from ischemia than wild-type cells

nervous system

abnormal retina rod bipolar cell morphology ( J:122896 )

• rod bipolar cells from null mice show significantly more damage from ischemia than wild-type cells