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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fgfr2tm1Dor
targeted mutation 1, David M Ornitz
MGI:3044679
Summary 34 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Fgfr2tm1Dor/Fgfr2svs involves: 129X1/SvJ * CXB5/ByJ * FVB/N MGI:3705020
cn2
Fgfr2tm1Dor/Fgfr2tm1Dor
Fgfr3tm6.1Cxd/Fgfr3tm6.1Cxd
Foxg1tm1(cre)Skm/Foxg1+
Fgfr1tm1Jpa/Fgfr1tm1Jpa
involves: 129 MGI:6116891
cn3
Fgfr2tm1Dor/Fgfr2tm1Dor
Foxg1tm1(cre)Skm/Foxg1+
Fgfr1tm3.1Sor/Fgfr1tm1Jpa
involves: 129 MGI:6116896
cn4
Fgfr2tm1Dor/Fgfr2tm1Dor
Foxg1tm1(cre)Skm/Foxg1+
Fgfr1tm1Jpa/Fgfr1tm1Jpa
involves: 129 MGI:6116895
cn5
Fgfr2tm1Dor/Fgfr2tm1Dor
Fgfr3tm6.1Cxd/Fgfr3tm6.1Cxd
Foxg1tm1(cre)Skm/Foxg1+
Fgfr1tm6.1Jrt/Fgfr1tm1Jpa
involves: 129 MGI:6116894
cn6
Fgfr2tm1Dor/Fgfr2tm1Dor
Fgfr3tm6.1Cxd/Fgfr3tm6.1Cxd
Foxg1tm1(cre)Skm/Foxg1+
Fgfr1tm3.1Sor/Fgfr1tm1Jpa
involves: 129 MGI:6116893
cn7
Fgfr2tm1Dor/Fgfr2+
Fgfr3tm6.1Cxd/Fgfr3tm6.1Cxd
Foxg1tm1(cre)Skm/Foxg1+
Fgfr1tm1Jpa/Fgfr1tm1Jpa
involves: 129 MGI:6116892
cn8
Cpa3tm3(icre)Hrr/Cpa3+
Fgfr1tm1Upir/Fgfr1tm1Upir
Fgfr2tm1Dor/Fgfr2tm1Dor
Tg(KRT5-cre)5132Jlj/0
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J MGI:5642134
cn9
Fgfr1tm1Jpa/Fgfr1tm1Jpa
Fgfr2tm1Dor/Fgfr2tm1Dor
Twist2tm1.1(cre)Dor/Twist2+
involves: 129S1/Sv * 129X1/SvJ MGI:5694227
cn10
Fgfr1tm1Jpa/Fgfr1tm1Jpa
Fgfr2tm1Dor/Fgfr2tm1Dor
Shhtm1(EGFP/cre)Cjt/Shh+
involves: 129S1/Sv * 129X1/SvJ MGI:5694226
cn11
Fgfr1tm1Jpa/Fgfr1+
Fgfr2tm1Dor/Fgfr2tm1.1Dor
Twist2tm1(cre)Dor/Twist2+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3813484
cn12
Fgfr2tm1Dor/Fgfr2tm1Dor
Lamb2tm1Jrs/Lamb2tm1Jrs
Tg(Mnx1-cre)1Jrs/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3766403
cn13
Fgfr1tm1Jpa/Fgfr1tm1Jpa
Fgfr2tm1Dor/Fgfr2tm1Dor
Tg(Msx2-rtTA)888Lma/0
Tg(tetO-cre)1Jaw/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5694225
cn14
Fgfr1tm1Jpa/Fgfr1tm1.1Jpa
Fgfr2tm1Dor/Fgfr2+
Twist2tm1(cre)Dor/Twist2+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3813483
cn15
Fgfr1tm1Jpa/Fgfr1tm1.1Jpa
Fgfr2tm1Dor/Fgfr2tm1.1Dor
Twist2tm1(cre)Dor/Twist2+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3813486
cn16
Fgfr1tm1Jpa/Fgfr1tm1Jpa
Fgfr2tm1Dor/Fgfr2tm1Dor
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J MGI:3829046
cn17
Fgfr1tm1Jpa/Fgfr1tm1Jpa
Fgfr2tm1Dor/Fgfr2tm1Dor
Tg(Pax3-cre)1Joe/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:5438672
cn18
Fgfr1tm1Jpa/Fgfr1tm1Jpa
Fgfr2tm1Dor/Fgfr2+
Tg(Pax3-cre)1Joe/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:5438670
cn19
Fgfr1tm1Jpa/Fgfr1+
Fgfr2tm1Dor/Fgfr2tm1Dor
Tg(Pax3-cre)1Joe/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:5438671
cn20
Fgfr1tm3.2Cxd/Fgfr1tm3.2Cxd
Fgfr2tm1Dor/Fgfr2tm1Dor
Foxa2tm2.1(cre/Esr1*)Moon/Foxa2+
involves: 129S6/SvEvTac * 129X1/SvJ MGI:3829047
cn21
Fgfr1tm1Swnr/Fgfr1tm1Swnr
Fgfr2tm1Dor/Fgfr2tm1Dor
Tg(KRT5-cre)5132Jlj/0
involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J MGI:5642123
cn22
Fgfr1tm1Upir/Fgfr1tm1Upir
Fgfr2tm1Dor/Fgfr2tm1Dor
Gt(ROSA)26Sortm1(Cdkn1b,EGFP)Dor/Gt(ROSA)26Sor+
Myl2tm1(cre)Krc/Myl2+
involves: 129/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 MGI:3775280
cn23
Fgfr2tm1Dor/Fgfr2tm1.1Dor
Twist2tm1(cre)Dor/Twist2+
involves: 129X1/SvJ MGI:3044704
cn24
Fgfr2tm1Dor/Fgfr2tm1Dor
Tg(Mnx1-cre)1Jrs/?
involves: 129X1/SvJ * C57BL/6 MGI:3766402
cn25
Fgfr2tm1Dor/Fgfr2tm1Dor
Tg(KRT5-cre)5132Jlj/0
involves: 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J MGI:5642116
cn26
Fgfr1tm1Upir/Fgfr1tm1Upir
Fgfr2tm1Dor/Fgfr2tm1Dor
Tg(KRT5-cre)5132Jlj/0
involves: 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J MGI:5642117
cn27
Fgfr2tm1Dor/Fgfr2tm1Dor
Tg(Sftpc-cre)1Blh/0
involves: 129X1/SvJ * C57BL/6 * DBA/2 MGI:3851800
cn28
Fgfr2tm1Dor/Fgfr2tm1Dor
H2az2Tg(Wnt1-cre)11Rth/0
involves: 129X1/SvJ * C57BL/6J * CBA/J MGI:4943276
cn29
Fgfr2tm1Dor/Fgfr2tm1Dor
Tg(Pax6-cre,GFP)1Pgr/0
involves: 129X1/SvJ * FVB MGI:4943279
cn30
Fgfr1tm1Upir/Fgfr1tm1Upir
Fgfr2tm1Dor/Fgfr2tm1Dor
Tg(GFAP-cre)25Mes/0
involves: 129X1/SvJ * FVB/N MGI:3641106
cn31
Fgfr2tm1Dor/Fgfr2tm1Dor
Tg(GFAP-cre)25Mes/0
involves: 129X1/SvJ * FVB/N MGI:3641105
cn32
Fgfr1tm1Jpa/Fgfr1+
Fgfr2tm1Dor/Fgfr2tm1Dor
Tg(Hoxb7-cre)5526Cmb/0
involves: FVB/N MGI:3525687
cn33
Fgfr1tm1Jpa/Fgfr1tm1Jpa
Fgfr2tm1Dor/Fgfr2tm1Dor
Tg(Hoxb7-cre)5526Cmb/0
involves: FVB/N MGI:3525690
cn34
Fgfr1tm1Jpa/Fgfr1tm1Jpa
Fgfr2tm1Dor/Fgfr2+
Tg(Hoxb7-cre)5526Cmb/0
involves: FVB/N MGI:3525679


Genotype
MGI:3705020
ht1
Allelic
Composition
Fgfr2tm1Dor/Fgfr2svs
Genetic
Background
involves: 129X1/SvJ * CXB5/ByJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr2svs mutation (1 available); any Fgfr2 mutation (22 available)
Fgfr2tm1Dor mutation (2 available); any Fgfr2 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
N
• seminal vesicle defects seen in svs/svs mice are complemented by presence of functional Fgfr2 allele




Genotype
MGI:6116891
cn2
Allelic
Composition
Fgfr2tm1Dor/Fgfr2tm1Dor
Fgfr3tm6.1Cxd/Fgfr3tm6.1Cxd
Foxg1tm1(cre)Skm/Foxg1+
Fgfr1tm1Jpa/Fgfr1tm1Jpa
Genetic
Background
involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm1Jpa mutation (0 available); any Fgfr1 mutation (170 available)
Fgfr2tm1Dor mutation (2 available); any Fgfr2 mutation (22 available)
Fgfr3tm6.1Cxd mutation (0 available); any Fgfr3 mutation (29 available)
Foxg1tm1(cre)Skm mutation (2 available); any Foxg1 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system




Genotype
MGI:6116896
cn3
Allelic
Composition
Fgfr2tm1Dor/Fgfr2tm1Dor
Foxg1tm1(cre)Skm/Foxg1+
Fgfr1tm3.1Sor/Fgfr1tm1Jpa
Genetic
Background
involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm1Jpa mutation (0 available); any Fgfr1 mutation (170 available)
Fgfr1tm3.1Sor mutation (0 available); any Fgfr1 mutation (170 available)
Fgfr2tm1Dor mutation (2 available); any Fgfr2 mutation (22 available)
Foxg1tm1(cre)Skm mutation (2 available); any Foxg1 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial

nervous system
• reduction in size across A/P and D/V axes at E12.5
• absent at E13.5 according to lack of Lhx8- and Nkx2-1-labeling of LGE region
• absent at E13.5 according to lack of Lhx8- and Nkx2-1-labeling of MGE region

vision/eye
• at E12.5




Genotype
MGI:6116895
cn4
Allelic
Composition
Fgfr2tm1Dor/Fgfr2tm1Dor
Foxg1tm1(cre)Skm/Foxg1+
Fgfr1tm1Jpa/Fgfr1tm1Jpa
Genetic
Background
involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm1Jpa mutation (0 available); any Fgfr1 mutation (170 available)
Fgfr2tm1Dor mutation (2 available); any Fgfr2 mutation (22 available)
Foxg1tm1(cre)Skm mutation (2 available); any Foxg1 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial

nervous system
• reduction in size across A/P and D/V axes at E12.5

vision/eye
• at E12.5




Genotype
MGI:6116894
cn5
Allelic
Composition
Fgfr2tm1Dor/Fgfr2tm1Dor
Fgfr3tm6.1Cxd/Fgfr3tm6.1Cxd
Foxg1tm1(cre)Skm/Foxg1+
Fgfr1tm6.1Jrt/Fgfr1tm1Jpa
Genetic
Background
involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm1Jpa mutation (0 available); any Fgfr1 mutation (170 available)
Fgfr1tm6.1Jrt mutation (0 available); any Fgfr1 mutation (170 available)
Fgfr2tm1Dor mutation (2 available); any Fgfr2 mutation (22 available)
Fgfr3tm6.1Cxd mutation (0 available); any Fgfr3 mutation (29 available)
Foxg1tm1(cre)Skm mutation (2 available); any Foxg1 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• brain morphology at E12.5




Genotype
MGI:6116893
cn6
Allelic
Composition
Fgfr2tm1Dor/Fgfr2tm1Dor
Fgfr3tm6.1Cxd/Fgfr3tm6.1Cxd
Foxg1tm1(cre)Skm/Foxg1+
Fgfr1tm3.1Sor/Fgfr1tm1Jpa
Genetic
Background
involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm1Jpa mutation (0 available); any Fgfr1 mutation (170 available)
Fgfr1tm3.1Sor mutation (0 available); any Fgfr1 mutation (170 available)
Fgfr2tm1Dor mutation (2 available); any Fgfr2 mutation (22 available)
Fgfr3tm6.1Cxd mutation (0 available); any Fgfr3 mutation (29 available)
Foxg1tm1(cre)Skm mutation (2 available); any Foxg1 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
N
• cell division at E8.75 according to mitotic marker p-HH3 immunoreactivity
• according to TUNEL assay at E8.75

nervous system




Genotype
MGI:6116892
cn7
Allelic
Composition
Fgfr2tm1Dor/Fgfr2+
Fgfr3tm6.1Cxd/Fgfr3tm6.1Cxd
Foxg1tm1(cre)Skm/Foxg1+
Fgfr1tm1Jpa/Fgfr1tm1Jpa
Genetic
Background
involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm1Jpa mutation (0 available); any Fgfr1 mutation (170 available)
Fgfr2tm1Dor mutation (2 available); any Fgfr2 mutation (22 available)
Fgfr3tm6.1Cxd mutation (0 available); any Fgfr3 mutation (29 available)
Foxg1tm1(cre)Skm mutation (2 available); any Foxg1 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
N
• cell survival and cell division at E8.75 according to mitotic marker p-HH3 immunoreactivity

nervous system
N
• brain morphology at E12.5




Genotype
MGI:5642134
cn8
Allelic
Composition
Cpa3tm3(icre)Hrr/Cpa3+
Fgfr1tm1Upir/Fgfr1tm1Upir
Fgfr2tm1Dor/Fgfr2tm1Dor
Tg(KRT5-cre)5132Jlj/0
Genetic
Background
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cpa3tm3(icre)Hrr mutation (0 available); any Cpa3 mutation (22 available)
Fgfr1tm1Upir mutation (0 available); any Fgfr1 mutation (170 available)
Fgfr2tm1Dor mutation (2 available); any Fgfr2 mutation (22 available)
Tg(KRT5-cre)5132Jlj mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body

integument
• increase in transepidermal water loss, indicating an epidermal barrier defect

hematopoietic system

homeostasis/metabolism
• increase in transepidermal water loss, indicating an epidermal barrier defect

immune system

cellular

reproductive system
• all females are sterile
• most males are sterile




Genotype
MGI:5694227
cn9
Allelic
Composition
Fgfr1tm1Jpa/Fgfr1tm1Jpa
Fgfr2tm1Dor/Fgfr2tm1Dor
Twist2tm1.1(cre)Dor/Twist2+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm1Jpa mutation (0 available); any Fgfr1 mutation (170 available)
Fgfr2tm1Dor mutation (2 available); any Fgfr2 mutation (22 available)
Twist2tm1.1(cre)Dor mutation (1 available); any Twist2 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• reduced cell proliferation in genital mesenchyme




Genotype
MGI:5694226
cn10
Allelic
Composition
Fgfr1tm1Jpa/Fgfr1tm1Jpa
Fgfr2tm1Dor/Fgfr2tm1Dor
Shhtm1(EGFP/cre)Cjt/Shh+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm1Jpa mutation (0 available); any Fgfr1 mutation (170 available)
Fgfr2tm1Dor mutation (2 available); any Fgfr2 mutation (22 available)
Shhtm1(EGFP/cre)Cjt mutation (1 available); any Shh mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• mice exhibit normal early growth, size and shape of genital tubercles

renal/urinary system
• abnormal maturation of urethral epithelium




Genotype
MGI:3813484
cn11
Allelic
Composition
Fgfr1tm1Jpa/Fgfr1+
Fgfr2tm1Dor/Fgfr2tm1.1Dor
Twist2tm1(cre)Dor/Twist2+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm1Jpa mutation (0 available); any Fgfr1 mutation (170 available)
Fgfr2tm1.1Dor mutation (0 available); any Fgfr2 mutation (22 available)
Fgfr2tm1Dor mutation (2 available); any Fgfr2 mutation (22 available)
Twist2tm1(cre)Dor mutation (0 available); any Twist2 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• there is about a 15% reduction in the length of the small intestine at E18.5 compared to controls




Genotype
MGI:3766403
cn12
Allelic
Composition
Fgfr2tm1Dor/Fgfr2tm1Dor
Lamb2tm1Jrs/Lamb2tm1Jrs
Tg(Mnx1-cre)1Jrs/?
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr2tm1Dor mutation (2 available); any Fgfr2 mutation (22 available)
Lamb2tm1Jrs mutation (1 available); any Lamb2 mutation (44 available)
Tg(Mnx1-cre)1Jrs mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• at P14, vesicles were highly clustered at synaptic site, but were abundant in preterminal portions




Genotype
MGI:5694225
cn13
Allelic
Composition
Fgfr1tm1Jpa/Fgfr1tm1Jpa
Fgfr2tm1Dor/Fgfr2tm1Dor
Tg(Msx2-rtTA)888Lma/0
Tg(tetO-cre)1Jaw/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm1Jpa mutation (0 available); any Fgfr1 mutation (170 available)
Fgfr2tm1Dor mutation (2 available); any Fgfr2 mutation (22 available)
Tg(Msx2-rtTA)888Lma mutation (0 available)
Tg(tetO-cre)1Jaw mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• underdeveloped from E11.5
• deficiency in proximodistal outgrowth at E12.5
• smaller in size at E15.5 with a lack in mesenchymal patterning
• at E11.0, genital mesenchyme exhibits a reduction in cell proliferation compared with in wild-type mice
• however, apoptosis rates are normal




Genotype
MGI:3813483
cn14
Allelic
Composition
Fgfr1tm1Jpa/Fgfr1tm1.1Jpa
Fgfr2tm1Dor/Fgfr2+
Twist2tm1(cre)Dor/Twist2+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm1.1Jpa mutation (0 available); any Fgfr1 mutation (170 available)
Fgfr1tm1Jpa mutation (0 available); any Fgfr1 mutation (170 available)
Fgfr2tm1Dor mutation (2 available); any Fgfr2 mutation (22 available)
Twist2tm1(cre)Dor mutation (0 available); any Twist2 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• there is about a 15% reduction in the length of the small intestine at E18.5 compared to controls




Genotype
MGI:3813486
cn15
Allelic
Composition
Fgfr1tm1Jpa/Fgfr1tm1.1Jpa
Fgfr2tm1Dor/Fgfr2tm1.1Dor
Twist2tm1(cre)Dor/Twist2+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm1.1Jpa mutation (0 available); any Fgfr1 mutation (170 available)
Fgfr1tm1Jpa mutation (0 available); any Fgfr1 mutation (170 available)
Fgfr2tm1.1Dor mutation (0 available); any Fgfr2 mutation (22 available)
Fgfr2tm1Dor mutation (2 available); any Fgfr2 mutation (22 available)
Twist2tm1(cre)Dor mutation (0 available); any Twist2 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• there is about a third reduction in the length of the small intestine at E18.5 compared to controls
• premature crypt-like structures occur in the small intestine of E18.5 embryos before the appearance of paneth cells
• proliferation of fibroblasts found in the proximal and distal small intestine mesenchyme is significantly reduced at E18.5

endocrine/exocrine glands
• premature crypt-like structures occur in the small intestine of E18.5 embryos before the appearance of paneth cells




Genotype
MGI:3829046
cn16
Allelic
Composition
Fgfr1tm1Jpa/Fgfr1tm1Jpa
Fgfr2tm1Dor/Fgfr2tm1Dor
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm1Jpa mutation (0 available); any Fgfr1 mutation (170 available)
Fgfr2tm1Dor mutation (2 available); any Fgfr2 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• severe facial clefting is seen

cardiovascular system
N
• despite ubiquitous expression of these genes in the anterior of the embryo, no defects in outflow tract development are seen

growth/size/body
• severe facial clefting is seen




Genotype
MGI:5438672
cn17
Allelic
Composition
Fgfr1tm1Jpa/Fgfr1tm1Jpa
Fgfr2tm1Dor/Fgfr2tm1Dor
Tg(Pax3-cre)1Joe/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm1Jpa mutation (0 available); any Fgfr1 mutation (170 available)
Fgfr2tm1Dor mutation (2 available); any Fgfr2 mutation (22 available)
Tg(Pax3-cre)1Joe mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• at E10.5, many apoptotic (TUNEL+) cells are present in the very loose mesenchyme adjacent to the ureteric bud, unlike in controls

renal/urinary system
• at E10.5, many apoptotic (TUNEL+) cells are present in the very loose mesenchyme adjacent to the ureteric bud, unlike in controls
• abnormally high rates of apoptosis are detected in mesenchyme dorsal to the initial ureteric bud at E10.5 and then in the rudimentary ureteric bud and Wolffian duct at E11.5
• at E10.5, mice exhibit local areas of hypoproliferation (decreased BrdU uptake) in mesenchyme dorsal to the ureteric bud (where metanephric mesenchyme should be present)
• at E10.5, mice exhibit no histologically recognizable condensing metanephric mesenchyme within the loose mesenchyme, unlike controls
• by E11.5, no definitive metanephric mesenchyme is seen around the unbranched ureteric buds, unlike in controls
• mice exhibit total renal aplasia
• however, mice develop bladders and structures originating from intermediate mesoderm including ovaries, testes, Mullerian ducts, and ductus deferens
• mice occasionally develop two initial ureteric buds from the Wolffian duct, unlike controls
• failure of uteretic buds to branch by E11.5
• by E11.5, ureteric buds fail to elongate or branch
• mice occasionally develop an ectopic ureteric bud
• a smaller ureteric bud is usually observed at E10.5 and E11.0

cellular
• at E10.5, many apoptotic (TUNEL+) cells are present in the very loose mesenchyme adjacent to the ureteric bud, unlike in controls
• abnormally high rates of apoptosis are detected in mesenchyme dorsal to the initial ureteric bud at E10.5 and then in the rudimentary ureteric bud and Wolffian duct at E11.5
• at E10.5, mice exhibit local areas of hypoproliferation (decreased BrdU uptake) in mesenchyme dorsal to the ureteric bud (where metanephric mesenchyme should be present)




Genotype
MGI:5438670
cn18
Allelic
Composition
Fgfr1tm1Jpa/Fgfr1tm1Jpa
Fgfr2tm1Dor/Fgfr2+
Tg(Pax3-cre)1Joe/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm1Jpa mutation (0 available); any Fgfr1 mutation (170 available)
Fgfr2tm1Dor mutation (2 available); any Fgfr2 mutation (22 available)
Tg(Pax3-cre)1Joe mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
N
• mice exhibit normal-appearing kidneys after birth
• kidneys exhibit normal cortical and medullary structures at E16.5 and remain normal throughout embryonic development




Genotype
MGI:5438671
cn19
Allelic
Composition
Fgfr1tm1Jpa/Fgfr1+
Fgfr2tm1Dor/Fgfr2tm1Dor
Tg(Pax3-cre)1Joe/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm1Jpa mutation (0 available); any Fgfr1 mutation (170 available)
Fgfr2tm1Dor mutation (2 available); any Fgfr2 mutation (22 available)
Tg(Pax3-cre)1Joe mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
N
• mice exhibit normal-appearing kidneys after birth
• kidneys exhibit normal cortical and medullary structures at E16.5 and remain normal throughout embryonic development




Genotype
MGI:3829047
cn20
Allelic
Composition
Fgfr1tm3.2Cxd/Fgfr1tm3.2Cxd
Fgfr2tm1Dor/Fgfr2tm1Dor
Foxa2tm2.1(cre/Esr1*)Moon/Foxa2+
Genetic
Background
involves: 129S6/SvEvTac * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm3.2Cxd mutation (0 available); any Fgfr1 mutation (170 available)
Fgfr2tm1Dor mutation (2 available); any Fgfr2 mutation (22 available)
Foxa2tm2.1(cre/Esr1*)Moon mutation (1 available); any Foxa2 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• despite disruption of vascular development mice survive to birth

cardiovascular system
N
• despite ubiquitous expression of these genes in the anterior of the embryo, no defects in outflow tract development are seen
• disruption of vascular development




Genotype
MGI:5642123
cn21
Allelic
Composition
Fgfr1tm1Swnr/Fgfr1tm1Swnr
Fgfr2tm1Dor/Fgfr2tm1Dor
Tg(KRT5-cre)5132Jlj/0
Genetic
Background
involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm1Swnr mutation (0 available); any Fgfr1 mutation (170 available)
Fgfr2tm1Dor mutation (2 available); any Fgfr2 mutation (22 available)
Tg(KRT5-cre)5132Jlj mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body

integument
• progressive loss of skin appendages
• progressive hair loss such that mice are hairless by 1 month of age
• mice develop epidermal hyperthickening combined with disorganization of the keratinocytes which progresses with age




Genotype
MGI:3775280
cn22
Allelic
Composition
Fgfr1tm1Upir/Fgfr1tm1Upir
Fgfr2tm1Dor/Fgfr2tm1Dor
Gt(ROSA)26Sortm1(Cdkn1b,EGFP)Dor/Gt(ROSA)26Sor+
Myl2tm1(cre)Krc/Myl2+
Genetic
Background
involves: 129/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm1Upir mutation (0 available); any Fgfr1 mutation (170 available)
Fgfr2tm1Dor mutation (2 available); any Fgfr2 mutation (22 available)
Gt(ROSA)26Sortm1(Cdkn1b,EGFP)Dor mutation (0 available); any Gt(ROSA)26Sor mutation (556 available)
Myl2tm1(cre)Krc mutation (2 available); any Myl2 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• mice exhibit smaller hearts than mice homozygous for null alleles of Fgfr1 and Fgfr2 due to decreased myocardial proliferation
• however, coronary development is normal
• mice exhibit thinner ventricular walls than mice homozygous for null alleles of Fgfr1 and Fgfr2




Genotype
MGI:3044704
cn23
Allelic
Composition
Fgfr2tm1Dor/Fgfr2tm1.1Dor
Twist2tm1(cre)Dor/Twist2+
Genetic
Background
involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr2tm1.1Dor mutation (0 available); any Fgfr2 mutation (22 available)
Fgfr2tm1Dor mutation (2 available); any Fgfr2 mutation (22 available)
Twist2tm1(cre)Dor mutation (0 available); any Twist2 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• osteoclasts were more mature (larger) than in control mice, but osteoclast activity did not differ from that of wild-type
• impaired osteoblast proliferation
• no increase in osteoblast apoptosis
• the mineral apposition rate (MAR) was undetectable at 3 and 4 weeks of age

craniofacial

growth/size/body
• characterized by reduced bone growth
• mice were 40% to 50% smaller than wild-type controls at 4 weeks of age
• normal growth resumed but adult mice remained 30% to 40% smaller than wild-type controls

limbs/digits/tail
• reduced length

skeleton
• the mineral apposition rate (MAR) was undetectable at 3 and 4 weeks of age
• shortened appendicular skeleton
• reduced length
• 40% decrease in metaphyseal area due to a reduction in the trabecular zone length and width
• shortened axial skeleton
• observed in some mice
• non-ossified gap in the dorsal midline of both the cervical and thoracic vertebrae
• bone mineral density was reduced in all mice
• though density increased with age, it remained decreased relative to that of wild-type
• while osteoblast differentiation was not affected, osteogenic regions contained fewer osteoblasts due to impaired proliferation
• several tarsal joins failed to develop, putatively due to a a failure of cavitation of the cartilaginous anlage prior to ossificiation of these bones
• skeletal dwarfism and decreased bone density
• decreased amount of trabecular bone; in some cases it was absent
• osteoclasts were more mature (larger) than in control mice, but osteoclast activity did not differ from that of wild-type
• reduced hypertrophic chondrocyte zone

hematopoietic system
• osteoclasts were more mature (larger) than in control mice, but osteoclast activity did not differ from that of wild-type

immune system
• osteoclasts were more mature (larger) than in control mice, but osteoclast activity did not differ from that of wild-type




Genotype
MGI:3766402
cn24
Allelic
Composition
Fgfr2tm1Dor/Fgfr2tm1Dor
Tg(Mnx1-cre)1Jrs/?
Genetic
Background
involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr2tm1Dor mutation (2 available); any Fgfr2 mutation (22 available)
Tg(Mnx1-cre)1Jrs mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• smaller than litter mate controls
• born in expected Mendelian numbers

behavior/neurological
• exhibited a mild tremor

nervous system
• at embryonic stages, vesicles were less concentrated at synaptic sites than in controls
• a similar defect was observed in neonates and during the first postnatal week
• the abnormality was transient and barely detectable by the third postnatal week
• neuromuscular junctions formed on schedule




Genotype
MGI:5642116
cn25
Allelic
Composition
Fgfr2tm1Dor/Fgfr2tm1Dor
Tg(KRT5-cre)5132Jlj/0
Genetic
Background
involves: 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr2tm1Dor mutation (2 available); any Fgfr2 mutation (22 available)
Tg(KRT5-cre)5132Jlj mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• loss of sebaceous glands

integument
• loss of sebaceous glands
• hair abnormalities




Genotype
MGI:5642117
cn26
Allelic
Composition
Fgfr1tm1Upir/Fgfr1tm1Upir
Fgfr2tm1Dor/Fgfr2tm1Dor
Tg(KRT5-cre)5132Jlj/0
Genetic
Background
involves: 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm1Upir mutation (0 available); any Fgfr1 mutation (170 available)
Fgfr2tm1Dor mutation (2 available); any Fgfr2 mutation (22 available)
Tg(KRT5-cre)5132Jlj mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body

integument
• keratinocyte proliferation is mildly increased at P18 and is strongly increased in the back and tail skin at 3 months of age (J:158802)
• however, keratinocytes in vitro show normal proliferation rate (J:158802)
• transepidermal water loss is slightly increased at P18 and is significantly increased at 6 months of age, indicating disturbed epidermal barrier function (J:158802)
• progressive skin inflammation, with a 60% increase in epidermal gamma-delta T cells, an increase in mast cells in the dermis, and increase in CD45+ alpha-beta and gamma-delta T cells in the dermis (J:158802)
• however, macrophage or neutrophil infiltrate is not seen (J:158802)
• loss of skin appendages
• sebaceous glands are virtually absent in the back skin of older mice
• mice are hairless by 2-4 months of age
• progressive hair loss and mice are hairless by 2-4 months of age (J:158802)
• hair follicles are abnormally shaped at P18 (first telogen)
• hair follicles are virtually absent in the back skin of older mice and only a few cysts are present in the dermis
• hair follicles are smaller at P18 (first telogen), but numbers are normal
• by P30, most follicles are in telogen compared to controls which have entered the second anagen
• a mild hypotrophy of the epidermis is seen at P5 (first anagen), but the dermis and appendages appear normal
• mice show only a rudimentary development of tight junctions in the epidermis
• bubble-like intercellular clefts between the keratinocytes of the stratum granulosum
• mice develop epidermal hyperthickening combined with disorganization of the keratinocytes at 2-3 months of age which progresses with age (J:158802)
• fragile appearing skin
• fibrosis develops in the dermis

endocrine/exocrine glands
• sebaceous glands are virtually absent in the back skin of older mice

cellular
• keratinocyte proliferation is mildly increased at P18 and is strongly increased in the back and tail skin at 3 months of age (J:158802)
• however, keratinocytes in vitro show normal proliferation rate (J:158802)

hematopoietic system
• mast cells in young cells are degranulated, followed by a decrease in degranulated mast cells thereafter
• increase in mast cell number between P7 and P9 is greater in mutants than in controls and remains high unlike in controls which show a decrease over time
• higher number of mast cell progenitors in the white adipose tissue
• mice show enhanced levels of IgE in the dermis and in the serum
• mice show enhanced levels of IgG1 in the dermis
• mice show enhanced levels of IgG2a in the dermis

homeostasis/metabolism
• transepidermal water loss is slightly increased at P18 and is significantly increased at 6 months of age, indicating disturbed epidermal barrier function (J:158802)
• transient increase in mast cell chemokines in the epidermis and dermis

immune system
• mast cells in young cells are degranulated, followed by a decrease in degranulated mast cells thereafter
• increase in mast cell number between P7 and P9 is greater in mutants than in controls and remains high unlike in controls which show a decrease over time
• higher number of mast cell progenitors in the white adipose tissue
• mice show enhanced levels of IgE in the dermis and in the serum
• mice show enhanced levels of IgG1 in the dermis
• mice show enhanced levels of IgG2a in the dermis
• transient increase in mast cell chemokines in the epidermis and dermis
• progressive skin inflammation, with a 60% increase in epidermal gamma-delta T cells, an increase in mast cells in the dermis, and increase in CD45+ alpha-beta and gamma-delta T cells in the dermis (J:158802)
• however, macrophage or neutrophil infiltrate is not seen (J:158802)

behavior/neurological
• high consumption of drinking water

reproductive system
• all females are infertile (J:158802)
• about 60% of males are infertile (J:158802)

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
atopic dermatitis DOID:3310 OMIM:603165
OMIM:PS603165
J:221184




Genotype
MGI:3851800
cn27
Allelic
Composition
Fgfr2tm1Dor/Fgfr2tm1Dor
Tg(Sftpc-cre)1Blh/0
Genetic
Background
involves: 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr2tm1Dor mutation (2 available); any Fgfr2 mutation (22 available)
Tg(Sftpc-cre)1Blh mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• E12.5 embryos are noticeably smaller than controls

growth/size/body
• E12.5 embryos are noticeably smaller than controls

respiratory system
• apoptosis is expanded caudally in the bronchial epithelium compared to controls at E11.25
• widespread apoptosis occurs in the lung epithelium by E12.5 and is also observed in the lung mesenchyme
• some E11.5 embryos have smaller lung branches with a bumpy, irregular morphology
• by E12.5, irregular outgrowths have arisen along the entire length of both main bronchi of the mutant lungs with outgrowths concentrated more caudally
• mesenchymal protrusions without an accompanying epithelial branch are occasionally observed during embryonic development




Genotype
MGI:4943276
cn28
Allelic
Composition
Fgfr2tm1Dor/Fgfr2tm1Dor
H2az2Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129X1/SvJ * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr2tm1Dor mutation (2 available); any Fgfr2 mutation (22 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
N
• lacrimal gland development is normal




Genotype
MGI:4943279
cn29
Allelic
Composition
Fgfr2tm1Dor/Fgfr2tm1Dor
Tg(Pax6-cre,GFP)1Pgr/0
Genetic
Background
involves: 129X1/SvJ * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr2tm1Dor mutation (2 available); any Fgfr2 mutation (22 available)
Tg(Pax6-cre,GFP)1Pgr mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• at E14.5, the presumptive lacrimal gland precursor remains a thin layer of epithelial cells with little proliferation and no budding unlike in wild-type mice
• at E14.5, mutants never develop lacrimal buds

vision/eye
• at E14.5, the presumptive lacrimal gland precursor remains a thin layer of epithelial cells with little proliferation and no budding unlike in wild-type mice
• at E14.5, mutants never develop lacrimal buds




Genotype
MGI:3641106
cn30
Allelic
Composition
Fgfr1tm1Upir/Fgfr1tm1Upir
Fgfr2tm1Dor/Fgfr2tm1Dor
Tg(GFAP-cre)25Mes/0
Genetic
Background
involves: 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm1Upir mutation (0 available); any Fgfr1 mutation (170 available)
Fgfr2tm1Dor mutation (2 available); any Fgfr2 mutation (22 available)
Tg(GFAP-cre)25Mes mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• numbers of astrocytes reaching the cortex is significantly reduced compared to controls at P7




Genotype
MGI:3641105
cn31
Allelic
Composition
Fgfr2tm1Dor/Fgfr2tm1Dor
Tg(GFAP-cre)25Mes/0
Genetic
Background
involves: 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr2tm1Dor mutation (2 available); any Fgfr2 mutation (22 available)
Tg(GFAP-cre)25Mes mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice show a subtle reduction in cortical size compared to control mice
• numbers of astrocytes reaching the cortex is significantly reduced compared to controls at P7; greatest loss (60%) is in the upper cortical layers with 22% loss in the subcortical white matter
• there is an intermediate reduction (39%) in astrocte density was seen in the inferior cortical layers




Genotype
MGI:3525687
cn32
Allelic
Composition
Fgfr1tm1Jpa/Fgfr1+
Fgfr2tm1Dor/Fgfr2tm1Dor
Tg(Hoxb7-cre)5526Cmb/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm1Jpa mutation (0 available); any Fgfr1 mutation (170 available)
Fgfr2tm1Dor mutation (2 available); any Fgfr2 mutation (22 available)
Tg(Hoxb7-cre)5526Cmb mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• 22% and 24% fewer glomeruli in E11.5 explants and adult kidneys, respectively
• defects in cortical stromal mesenchyme patterning, showing aberrantly thickened stroma in subcapsular regions in E13.5 kidneys and regions of massive subcapsular apoptosis in stroma
• absent intercalated stripes of stromal cells in E13.5 kidneys
• 20% of adult mutants had hydronephrosis occurring unilaterally or bilaterally
• E13.5 and E16.5 kidneys were smaller than controls
• 80% of adult mutants had small, abnormally shaped kidneys
• range of ureteric bud defects at E16.5, including extremely small kidneys with large areas devoid of ureteric tissue
• increased apoptotic nuclei in ureteric buds (2-3 apoptotic nuclei compared to none or just one in controls)
• decreased rates of proliferation in ureteric bud tips compared with controls
• E11.5 ureteric bud explants exhibited aberrant branching and had abnormally thin, long ureteric stalks and fewer peripheral tips, with a range in phenotype severity
• decrease in the mean number of ureteric bud tips on the surface of E16.5 kidneys (89.5 versus 271 in control)




Genotype
MGI:3525690
cn33
Allelic
Composition
Fgfr1tm1Jpa/Fgfr1tm1Jpa
Fgfr2tm1Dor/Fgfr2tm1Dor
Tg(Hoxb7-cre)5526Cmb/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm1Jpa mutation (0 available); any Fgfr1 mutation (170 available)
Fgfr2tm1Dor mutation (2 available); any Fgfr2 mutation (22 available)
Tg(Hoxb7-cre)5526Cmb mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• reduced numbers of glomeruli in both embryonic and adult kidneys
• some adult mutants had hydronephrosis occurring unilaterally or bilaterally
• E13.5 and E16.5 kidneys were smaller than controls
• many adult mutants had small, abnormally shaped kidneys
• E11.5 ureteric bud explants had abnormally thin, long ureteric stalks and fewer peripheral tips, with a range in phenotype severity
• decrease in the mean number of ureteric bud tips on the surface of E16.5 kidneys
• range of ureteric bud defects at E16.5, including extremely small kidneys with large areas devoid of ureteric tissue




Genotype
MGI:3525679
cn34
Allelic
Composition
Fgfr1tm1Jpa/Fgfr1tm1Jpa
Fgfr2tm1Dor/Fgfr2+
Tg(Hoxb7-cre)5526Cmb/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm1Jpa mutation (0 available); any Fgfr1 mutation (170 available)
Fgfr2tm1Dor mutation (2 available); any Fgfr2 mutation (22 available)
Tg(Hoxb7-cre)5526Cmb mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
N
• normal kidneys and no apparent renal abnormalities





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last database update
01/12/2021
MGI 6.16
The Jackson Laboratory