All Phenotypes Tg(TcraH-Y,TcrbH-Y)71Vbo MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(TcraH-Y,TcrbH-Y)71Vbo
transgene insertion 71, Harald von Boehmer
MGI:3044562

Summary

48 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Elavl1^tm1Dkon/Elavl1^tm1Dkon Tg(Lck-cre)I57Jxm/0 Tg(TcraH-Y,TcrbH-Y)71Vbo/?	B6.Cg-Elavl1^tm1Dkon Tg(Lck-cre)I57Jxm Tg(TcraH-Y,TcrbH-Y)71Vbo	MGI:3847930
cn2	Grb2^tm1.1Hua/Grb2^tm1.1Hua Tg(Lck-cre)1Jtak/0 Tg(TcraH-Y,TcrbH-Y)71Vbo/0	involves: 129 * C57BL/6 * C57BL/6J * DBA/2J	MGI:4818273
cn3	Prkd2^tm1.1Shoy/Prkd2^tm1.1Shoy Prkd3^tm1.1Shoy/Prkd3^tm1.1Shoy Tg(Lck-cre)1Jtak/0 Tg(TcraH-Y,TcrbH-Y)71Vbo/0	involves: 129 * C57BL/6 * C57BL/6J * DBA/2J	MGI:5805813
cn4	Ctcf^tm2Gal/Ctcf^tm2Gal Tg(Lck-cre)1Cwi/0 Tg(TcraH-Y,TcrbH-Y)71Vbo/0	involves: 129P2/OlaHsd * C57BL/6 * C57BL/10 * DBA/2J	MGI:3829022
cn5	Plcg1^tm1Gcrp/Plcg1^tm1Rwen Tg(Cd4-cre)1Cwi/0 Tg(TcraH-Y,TcrbH-Y)71Vbo/0	involves: 129X1/SvJ * C57BL/6 * DBA/2	MGI:4437915
cx6	Tg(Lck-CrmA)1Hed/0 Tg(TcraH-Y,TcrbH-Y)71Vbo/0	BALB/c * C57BL/6	MGI:3588982
cx7	Il6st^tm1Thir/Il6st^tm1Thir Tg(TcraH-Y,TcrbH-Y)71Vbo/?	involves: 129 * C57BL/6 * DBA	MGI:3843819
cx8	Tg(TcraH-Y,TcrbH-Y)71Vbo/? Themis^tm1Lov/Themis^tm1Lov	involves: 129 * C57BL/6 * DBA/2	MGI:4353388
cx9	Tespa1^tm1Smoc/Tespa1^tm1Smoc Tg(TcraH-Y,TcrbH-Y)71Vbo/0	involves: 129 * C57BL/6 * DBA/2J	MGI:5432919
cx10	Git2^Gt(XG510)Byg/Git2^Gt(XG510)Byg Tg(TcraH-Y,TcrbH-Y)71Vbo/0	involves: 129 * C57BL/6J * DBA/2J	MGI:4461273
cx11	Zap70^tm2.1Mmal/Zap70^tm2.1Mmal Tg(TcraH-Y,TcrbH-Y)71Vbo/0	involves: 129P2/OlaHsd * BALB/cJ * C57BL/6J * DBA/2J	MGI:3790317
cx12	Zap70^tm1.1Mmal/Zap70^tm1.1Mmal Tg(TcraH-Y,TcrbH-Y)71Vbo/0	involves: 129P2/OlaHsd * BALB/cJ * C57BL/6J * DBA/2J	MGI:3790316
cx13	Map2k6^tm1Ina/Map2k6^tm1Ina Tg(TcraH-Y,TcrbH-Y)71Vbo/0	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J	MGI:3692608
cx14	Hcls1^tm1Wtn/Hcls1^tm1Wtn Tg(TcraH-Y,TcrbH-Y)71Vbo/0	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J	MGI:3625325
cx15	H2^b/H2^b Ptcra^tm1Vbo/Ptcra^tm1Vbo Tg(TcraH-Y,TcrbH-Y)71Vbo/?	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J	MGI:3807289
cx16	Tg(TcraH-Y,TcrbH-Y)71Vbo/0 Tnfrsf25^tm1Mjo/Tnfrsf25^tm1Mjo	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J	MGI:3698842
cx17	Mcl1^tm1Yen/Mcl1^tm1Yen Tg(TcraH-Y,TcrbH-Y)71Vbo/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2	MGI:3837393
cx18	E2f2^tm1Zubi/E2f2^tm1Zubi Tg(TcraH-Y,TcrbH-Y)71Vbo/?	involves: 129S1/Sv * C57BL/6 * C57BL/6J * DBA/2J	MGI:3723020
cx19	Itk^tm1Litt/Itk^tm1Litt Tg(TcraH-Y,TcrbH-Y)71Vbo/0	involves: 129S4/SvJae * C57BL/6 * DBA/2J	MGI:3771702
cx20	Cd8b1^tm1Litt/Cd8b1⁺ Tg(TcraH-Y,TcrbH-Y)71Vbo/0	involves: 129S4/SvJae * C57BL/6J * DBA/2	MGI:3665230
cx21	Cd8b1^tm1Litt/Cd8b1^tm1Litt Tg(TcraH-Y,TcrbH-Y)71Vbo/0	involves: 129S4/SvJae * C57BL/6J * DBA/2	MGI:3665231
cx22	Zap70^tm2.1Weis/Zap70^tm2.1Weis Tg(TcraH-Y,TcrbH-Y)71Vbo/?	involves: 129S4/SvJae * C57BL/6J * DBA/2J	MGI:4399133
cx23	Tg(TcraH-Y,TcrbH-Y)71Vbo/? Themis^tm1Gasc/Themis^tm1Gasc	involves: 129S6/SvEvTac * C57BL/6 * DBA/2	MGI:4353113
cx24	Lcp2^tm3Gak/Lcp2^tm3Gak Tg(TcraH-Y,TcrbH-Y)71Vbo/?	involves: 129S6/SvEvTac * C57BL/6 * DBA/2J	MGI:3778796
cx25	Lcp2^tm4Gak/Lcp2^tm4Gak Tg(TcraH-Y,TcrbH-Y)71Vbo/?	involves: 129S6/SvEvTac * C57BL/6 * DBA * FVB/N	MGI:3778801
cx26	Cd8a^tm1Asin/Cd8a^tm1Asin Rag2^tm1Fwa/Rag2^tm1Fwa Tg(TcraH-Y,TcrbH-Y)71Vbo/?	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J	MGI:3760752
cx27	Ets1^tm1Jml/Ets1^tm1Jml Tg(TcraH-Y,TcrbH-Y)71Vbo/0	involves: 129S/SvEv * C57BL/6 * C57BL/6J * DBA/2J	MGI:3833459
cx28	Rag2^tm1Fwa/Rag2^tm1Fwa Tg(TcraH-Y,TcrbH-Y)71Vbo/? Themis^5AT161/Themis^5AT161	involves: 129S/SvEv * C57BL/6 * DBA/2	MGI:4353424
cx29	Rag2^tm1Fwa/Rag2^tm1Fwa Tg(TcraH-Y,TcrbH-Y)71Vbo/?	involves: 129S/SvEv * C57BL/6J * DBA/2J	MGI:3760751
cx30	Elk4^tm1Rtr/Elk4^tm1Rtr Tg(TcraH-Y,TcrbH-Y)71Vbo/?	involves: 129/Sv * C57BL/6 * DBA/2J	MGI:3851783
cx31	Tg(Lck-FADD)1Hed/0 Tg(TcraH-Y,TcrbH-Y)71Vbo/0	involves: BALB/c * C57BL/6J * C57L/J * DBA/2J	MGI:3588980
cx32	Zap70^m1Saka/Zap70^m1Saka Tg(TcraH-Y,TcrbH-Y)71Vbo/0	involves: BALB/c * C57BL/6J * DBA/2J	MGI:3698744
cx33	Lck^tm1Dbs/Lck^tm1Dbs Tg(TcraH-Y,TcrbH-Y)71Vbo/0	involves: C3H * C57BL/6 * DBA/2J	MGI:3698309
cx34	Fbn1^Tsk/Fbn1⁺ Tg(TcraH-Y,TcrbH-Y)71Vbo/?	involves: C57BL/10 * DBA/2	MGI:5301104
cx35	Tg(Lck-Stk17b)26.1Wals/? Tg(TcraH-Y,TcrbH-Y)71Vbo/?	involves: C57BL/6 * C57BL/10	MGI:5140299
cx36	Lcp2^tm1.1Wz/Lcp2^tm1.1Wz Tg(TcraH-Y,TcrbH-Y)71Vbo/0	involves: C57BL/6 * C57BL/6J * DBA/2J	MGI:3850711
cx37	Ptpn22^tm1.1Kas/Ptpn22^tm1.1Kas Tg(TcraH-Y,TcrbH-Y)71Vbo/0	involves: C57BL/6 * C57BL/6J * DBA/2J	MGI:5294246
cx38	Tg(LCKprBCL2)36Sjk/0 Tg(TcraH-Y,TcrbH-Y)71Vbo/0	involves: C57BL/6 * C57BL/6J * DBA/2J	MGI:5661489
cx39	Cd3e^tm1.1Geno/Cd3e^tm1.1Geno Tg(TcraH-Y,TcrbH-Y)71Vbo/0	involves: C57BL/6 * C57BL/6J * DBA/2J	MGI:5474203
cx40	Tg(Cd4-BCL2G101AD102A*D103A)AWnt/0 Tg(TcraH-Y,TcrbH-Y)71Vbo/0	involves: C57BL/6 * C57BL/6J * DBA/2J	MGI:5661488
cx41	Sit1^tm1Lsmn/Sit1^tm1Lsmn Tg(TcraH-Y,TcrbH-Y)71Vbo/?	involves: C57BL/6 * C57BL/6J * DBA/2J	MGI:3589737
cx42	Tg(Cd8aCd8b)3Erob/0 Tg(TcraH-Y,TcrbH-Y)71Vbo/0	involves: C57BL/6 * DBA/2	MGI:3834902
cx43	Tg(CD2-Zbtb7b)C8Rbo/? Tg(TcraH-Y,TcrbH-Y)71Vbo/?	involves: C57BL/6 * DBA/2J	MGI:3817861
cx44	Gimap5^m1Btlr/Gimap5^m1Btlr Tg(TcraH-Y,TcrbH-Y)71Vbo/0	involves: C57BL/6J * DBA/2J	MGI:4456989
cx45	Cd247^tm2.1Lov/Cd247^tm2.1Lov Tg(TcraH-Y,TcrbH-Y)71Vbo/0	involves: C57BL/6J * DBA/2J	MGI:5468139
cx46	Rasgrp1^tm1.1Wz/Rasgrp1^tm1.1Wz Tg(TcraH-Y,TcrbH-Y)71Vbo/?	involves: C57BL/6J * DBA/2J	MGI:5695367
tg47	Tg(TcraH-Y,TcrbH-Y)71Vbo/?	involves: C57BL/6 * DBA/2J	MGI:3817862
tg48	Tg(TcraH-Y,TcrbH-Y)71Vbo/?	involves: C57BL/6J * C57L/J * DBA/2J	MGI:3588781

Allelic Composition	Elavl1^tm1Dkon/Elavl1^tm1Dkon Tg(Lck-cre)I57Jxm/0 Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background	B6.Cg-Elavl1^tm1Dkon Tg(Lck-cre)I57Jxm Tg(TcraH-Y,TcrbH-Y)71Vbo

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elavl1^tm1Dkon mutation (1 available); any Elavl1 mutation (43 available)
Tg(Lck-cre)I57Jxm mutation (1 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased thymocyte number ( J:148866 )

• there is a 50% increase in transgenic CD8 single-positive thymocytes in male mice

• however, there is no corresponding increase in transgenic CD8⁺ T cells in the periphery

abnormal negative T cell selection ( J:148866 )

• there is a 50% increase in transgenic CD8 single-positive thymocytes in male mice suggesting a defect in negative selection

hematopoietic system

increased thymocyte number ( J:148866 )

• there is a 50% increase in transgenic CD8 single-positive thymocytes in male mice

• however, there is no corresponding increase in transgenic CD8⁺ T cells in the periphery

abnormal negative T cell selection ( J:148866 )

• there is a 50% increase in transgenic CD8 single-positive thymocytes in male mice suggesting a defect in negative selection

endocrine/exocrine glands

increased thymocyte number ( J:148866 )

• there is a 50% increase in transgenic CD8 single-positive thymocytes in male mice

• however, there is no corresponding increase in transgenic CD8⁺ T cells in the periphery

Allelic Composition	Grb2^tm1.1Hua/Grb2^tm1.1Hua Tg(Lck-cre)1Jtak/0 Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background	involves: 129 * C57BL/6 * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grb2^tm1.1Hua mutation (0 available); any Grb2 mutation (42 available)
Tg(Lck-cre)1Jtak mutation (3 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T cell differentiation ( J:161294 )

• positive selection of CD8+ cells in female mice is impaired compared to in H-Y TCR control mice

• male mice fail to exhibit negative selection of double positive and CD8+ T cells unlike H-Y TCR control mice

• Staphylococcal enterotoxin B (SEB)-treated mice fail to exhibit a decrease in TCR Vbeta8+ thymocytes unlike similarly treated H-Y TCR control mice

increased double-positive T cell number ( J:161294 )

• in male mice

decreased CD4-positive, alpha-beta T cell number ( J:161294 )

• in male mice

decreased CD8-positive, alpha-beta T cell number ( J:161294 )

• in female mice

increased CD8-positive, alpha-beta T cell number ( J:161294 )

• in male mice

hematopoietic system

abnormal T cell differentiation ( J:161294 )

• positive selection of CD8+ cells in female mice is impaired compared to in H-Y TCR control mice

• male mice fail to exhibit negative selection of double positive and CD8+ T cells unlike H-Y TCR control mice

• Staphylococcal enterotoxin B (SEB)-treated mice fail to exhibit a decrease in TCR Vbeta8+ thymocytes unlike similarly treated H-Y TCR control mice

increased double-positive T cell number ( J:161294 )

• in male mice

decreased CD4-positive, alpha-beta T cell number ( J:161294 )

• in male mice

decreased CD8-positive, alpha-beta T cell number ( J:161294 )

• in female mice

increased CD8-positive, alpha-beta T cell number ( J:161294 )

• in male mice

Allelic Composition	Prkd2^tm1.1Shoy/Prkd2^tm1.1Shoy Prkd3^tm1.1Shoy/Prkd3^tm1.1Shoy Tg(Lck-cre)1Jtak/0 Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background	involves: 129 * C57BL/6 * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkd2^tm1.1Shoy mutation (1 available); any Prkd2 mutation (41 available)
Prkd3^tm1.1Shoy mutation (0 available); any Prkd3 mutation (61 available)
Tg(Lck-cre)1Jtak mutation (3 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased thymocyte number ( J:236298 )

• CD8+ single positive thymocytes

increased double-positive T cell number ( J:236298 )

endocrine/exocrine glands

decreased thymocyte number ( J:236298 )

• CD8+ single positive thymocytes

hematopoietic system

decreased thymocyte number ( J:236298 )

• CD8+ single positive thymocytes

increased double-positive T cell number ( J:236298 )

Allelic Composition	Ctcf^tm2Gal/Ctcf^tm2Gal Tg(Lck-cre)1Cwi/0 Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * C57BL/10 * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctcf^tm2Gal mutation (0 available); any Ctcf mutation (78 available)
Tg(Lck-cre)1Cwi mutation (3 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T cell differentiation ( J:143271 )

• T cell development is more severely arrested than in Ctcf^tm1Laat/Ctcf^tm1Laat Tg(Lck-cre)1Cwi mice

• mice exhibit a severe block to T cell development at the immature single positive stage

decreased double-positive T cell number ( J:143271 )

• mice exhibit a almost complete lack of double positive cells in the thymus

decreased CD4-positive, alpha-beta T cell number ( J:143271 )

• strongly reduced in the spleen

decreased CD8-positive, alpha-beta T cell number ( J:143271 )

• strongly reduced in the spleen

hematopoietic system

abnormal T cell differentiation ( J:143271 )

• T cell development is more severely arrested than in Ctcf^tm1Laat/Ctcf^tm1Laat Tg(Lck-cre)1Cwi mice

• mice exhibit a severe block to T cell development at the immature single positive stage

decreased double-positive T cell number ( J:143271 )

• mice exhibit a almost complete lack of double positive cells in the thymus

decreased CD4-positive, alpha-beta T cell number ( J:143271 )

• strongly reduced in the spleen

decreased CD8-positive, alpha-beta T cell number ( J:143271 )

• strongly reduced in the spleen

Allelic Composition	Plcg1^tm1Gcrp/Plcg1^tm1Rwen Tg(Cd4-cre)1Cwi/0 Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background	involves: 129X1/SvJ * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plcg1^tm1Gcrp mutation (0 available); any Plcg1 mutation (48 available)
Plcg1^tm1Rwen mutation (0 available); any Plcg1 mutation (48 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

thymus hyperplasia ( J:157757 )

• in male mice, which undergo negative selection, compared with Plcg1^tm1Gcrp/Plcg1⁺ Tg(CD4-cre)1Cwi Tg(TcraH-Y,TcrbH-Y)71Vbo mice

decreased double-negative T cell number ( J:157757 )

• in male mice, which undergo negative selection, compared with Plcg1^tm1Gcrp/Plcg1⁺ Tg(CD4-cre)1Cwi Tg(TcraH-Y,TcrbH-Y)71Vbo mice

increased double-positive T cell number ( J:157757 )

• in male mice, which undergo negative selection, compared with Plcg1^tm1Gcrp/Plcg1⁺ Tg(CD4-cre)1Cwi Tg(TcraH-Y,TcrbH-Y)71Vbo mice

decreased CD8-positive, alpha-beta T cell number ( J:157757 )

• female mice, which undergo positive selection, exhibit a decrease in total CD8 single positive cells and CD8 single positive cells in the T3-70^hi cell compartment compared with Plcg1^tm1Gcrp/Plcg1⁺ Tg(CD4-cre)1Cwi Tg(TcraH-Y,TcrbH-Y)71Vbo mice

increased CD8-positive, alpha-beta T cell number ( J:157757 )

• male mice, which undergo negative selection, exhibit an increase in CD8 single positive cells in the T3-70^hi cell compartment compared with Plcg1^tm1Gcrp/Plcg1⁺ Tg(CD4-cre)1Cwi Tg(TcraH-Y,TcrbH-Y)71Vbo mice

hematopoietic system

thymus hyperplasia ( J:157757 )

• in male mice, which undergo negative selection, compared with Plcg1^tm1Gcrp/Plcg1⁺ Tg(CD4-cre)1Cwi Tg(TcraH-Y,TcrbH-Y)71Vbo mice

decreased double-negative T cell number ( J:157757 )

• in male mice, which undergo negative selection, compared with Plcg1^tm1Gcrp/Plcg1⁺ Tg(CD4-cre)1Cwi Tg(TcraH-Y,TcrbH-Y)71Vbo mice

increased double-positive T cell number ( J:157757 )

• in male mice, which undergo negative selection, compared with Plcg1^tm1Gcrp/Plcg1⁺ Tg(CD4-cre)1Cwi Tg(TcraH-Y,TcrbH-Y)71Vbo mice

decreased CD8-positive, alpha-beta T cell number ( J:157757 )

increased CD8-positive, alpha-beta T cell number ( J:157757 )

endocrine/exocrine glands

thymus hyperplasia ( J:157757 )

• in male mice, which undergo negative selection, compared with Plcg1^tm1Gcrp/Plcg1⁺ Tg(CD4-cre)1Cwi Tg(TcraH-Y,TcrbH-Y)71Vbo mice

Allelic Composition	Tg(Lck-CrmA)1Hed/0 Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background	BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Lck-CrmA)1Hed mutation (0 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:100451 )

N	• HY mediated negative selection in this TCR transgenic model was not blocked or altered by the presence of Tg(Lck-CrmA)1Hed

Allelic Composition	Il6st^tm1Thir/Il6st^tm1Thir Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background	involves: 129 * C57BL/6 * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6st^tm1Thir mutation (1 available); any Il6st mutation (80 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal negative T cell selection ( J:133059 )

• the number of CD8^lo single-positive thymocytes bearing transgenic TCR are several fold higher than in controls indicating a defect in negative selection

hematopoietic system

abnormal negative T cell selection ( J:133059 )

• the number of CD8^lo single-positive thymocytes bearing transgenic TCR are several fold higher than in controls indicating a defect in negative selection

Allelic Composition	Tg(TcraH-Y,TcrbH-Y)71Vbo/? Themis^tm1Lov/Themis^tm1Lov
Genetic Background	involves: 129 * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)
Themis^tm1Lov mutation (0 available); any Themis mutation (55 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal negative T cell selection ( J:151075 )

• the percentage of DP thymocytes is consistently higher in male mice than in male transgenics on a wild-type background, which suggests that negative selection occurs less efficiently

abnormal positive T cell selection ( J:151075 )

• higher double positive thymocyte numbers and fewer single-positive thymoyctes in females indicate a defect in positive selection

increased double-positive T cell number ( J:151075 )

• double-positive thymocytes are increased in female mice

decreased single-positive T cell number ( J:151075 )

• CD8 single-positive thymocyte nubmers are reduced in these female mice

hematopoietic system

abnormal negative T cell selection ( J:151075 )

• the percentage of DP thymocytes is consistently higher in male mice than in male transgenics on a wild-type background, which suggests that negative selection occurs less efficiently

abnormal positive T cell selection ( J:151075 )

• higher double positive thymocyte numbers and fewer single-positive thymoyctes in females indicate a defect in positive selection

increased double-positive T cell number ( J:151075 )

• double-positive thymocytes are increased in female mice

decreased single-positive T cell number ( J:151075 )

• CD8 single-positive thymocyte nubmers are reduced in these female mice

Allelic Composition	Tespa1^tm1Smoc/Tespa1^tm1Smoc Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background	involves: 129 * C57BL/6 * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tespa1^tm1Smoc mutation (1 available); any Tespa1 mutation (33 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased CD8-positive, alpha-beta T cell number ( J:186446 )

• in the thymus

• in the periphery

immune system

decreased CD8-positive, alpha-beta T cell number ( J:186446 )

• in the thymus

• in the periphery

Allelic Composition	Git2^Gt(XG510)Byg/Git2^Gt(XG510)Byg Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background	involves: 129 * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Git2^Gt(XG510)Byg mutation (3 available); any Git2 mutation (78 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal positive T cell selection ( J:160613 )

• the generation of CD8+ single-positive thymocytes in female H-Y TCR transgenic is impaired

decreased CD8-positive, alpha-beta T cell number ( J:160613 )

• the generation of CD8+ single-positive thymocytes in female H-Y TCR transgenic is impaired

abnormal CD4-positive, alpha-beta T cell physiology ( J:160613 )

abnormal CD8-positive, alpha-beta T cell physiology ( J:160613 )

immune system

abnormal positive T cell selection ( J:160613 )

• the generation of CD8+ single-positive thymocytes in female H-Y TCR transgenic is impaired

decreased CD8-positive, alpha-beta T cell number ( J:160613 )

• the generation of CD8+ single-positive thymocytes in female H-Y TCR transgenic is impaired

abnormal CD4-positive, alpha-beta T cell physiology ( J:160613 )

abnormal CD8-positive, alpha-beta T cell physiology ( J:160613 )

cellular

abnormal cell migration ( J:160613 )

• in the absence of any stimulus basal migration is modestly but consistently greater for the CD4SP and CD8SP subsets of thymocytes

Allelic Composition	Zap70^tm2.1Mmal/Zap70^tm2.1Mmal Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background	involves: 129P2/OlaHsd * BALB/cJ * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)
Zap70^tm2.1Mmal mutation (0 available); any Zap70 mutation (55 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:71099 )

N	• double negative and double positive cells from thymi of mutants and wild-type mice have similar levels of CD5 expression

abnormal thymus cell ratio ( J:71099 )

• CD8+/T3.70^high cell number in thymus displays a 2-3-fold reduction compared to wild-type or homozygous Zap70^tm1.1Mmal hemizygous transgenic animals

• a novel T3.70^high/double positive T cell population comprising 30% of thymocytes is observed in mutant thymi compared to mice expressing the Tg(TcraH-Y,TcrbH-Y)71Vbo transgene alone

abnormal T cell morphology ( J:71099 )

• single positive thymocytes have lower CD5 surface expression than thymocytes from wild-type Tg(TcrLCMV)327Sdz or Tg(TcraH-Y,TcrbH-Y)71Vbo mice or Zap70^tm1.1Mmal/ Tg(TcrLCMV)327Sdz or Zap70^tm1.1Mmal/ Tg(TcraH-Y,TcrbH-Y)71Vbo animals

abnormal lymph node cell ratio ( J:71099 )

• CD8+/T3.70^high cell number in lymph nodes displays a 2-3-fold reduction compared to wild-type or homozygous Zap70^tm1.1Mmal hemizygous transgenic animals

hematopoietic system

abnormal thymus cell ratio ( J:71099 )

• CD8+/T3.70^high cell number in thymus displays a 2-3-fold reduction compared to wild-type or homozygous Zap70^tm1.1Mmal hemizygous transgenic animals

• a novel T3.70^high/double positive T cell population comprising 30% of thymocytes is observed in mutant thymi compared to mice expressing the Tg(TcraH-Y,TcrbH-Y)71Vbo transgene alone

abnormal T cell morphology ( J:71099 )

endocrine/exocrine glands

abnormal thymus cell ratio ( J:71099 )

• CD8+/T3.70^high cell number in thymus displays a 2-3-fold reduction compared to wild-type or homozygous Zap70^tm1.1Mmal hemizygous transgenic animals

• a novel T3.70^high/double positive T cell population comprising 30% of thymocytes is observed in mutant thymi compared to mice expressing the Tg(TcraH-Y,TcrbH-Y)71Vbo transgene alone

Allelic Composition	Zap70^tm1.1Mmal/Zap70^tm1.1Mmal Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background	involves: 129P2/OlaHsd * BALB/cJ * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)
Zap70^tm1.1Mmal mutation (0 available); any Zap70 mutation (55 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:71099 )

N	• numbers of CD8+/T3.70^high thymocytes and lymph node T cells are normal, indicating that the Zap70 mutation has no effect on positive selection of T cells • double negative and double positive cells from thymi of female mutants and wild-type mice have similar levels of CD5 expression

Allelic Composition	Map2k6^tm1Ina/Map2k6^tm1Ina Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map2k6^tm1Ina mutation (1 available); any Map2k6 mutation (42 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal thymus cell ratio ( J:100093 )

• in males, an increased number of in TCRalphabeta^intCD69^lo CD4^loCD8^lo thymocytes is observed compared to Map2k6-sufficient transgenic mice

hematopoietic system

abnormal thymus cell ratio ( J:100093 )

• in males, an increased number of in TCRalphabeta^intCD69^lo CD4^loCD8^lo thymocytes is observed compared to Map2k6-sufficient transgenic mice

cellular

decreased apoptosis ( J:100093 )

• percentage of caspase-active cells in TCRalphabeta^intCD69^lo CD4^hiCD8^hi thymocyte population of males is lower than in Map2k6-sufficient transgene-expressing cells; as well, a smaller percentage of cells show DNA fragmentation

endocrine/exocrine glands

abnormal thymus cell ratio ( J:100093 )

• in males, an increased number of in TCRalphabeta^intCD69^lo CD4^loCD8^lo thymocytes is observed compared to Map2k6-sufficient transgenic mice

Allelic Composition	Hcls1^tm1Wtn/Hcls1^tm1Wtn Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hcls1^tm1Wtn mutation (0 available); any Hcls1 mutation (26 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal negative T cell selection ( J:28146 )

• in the thymus of transgenic male Hcls1-null mice, significant numbers of double positive thymocytes do not undergo negative selection and remain undeleted

decreased double-positive T cell number ( J:28146 )

• in Hcls1-expressing transgenic male mice, the population of double positive thymocytes is reduced to 10% of that in female ransgenic Hcls1-expressing animals

hematopoietic system

abnormal negative T cell selection ( J:28146 )

• in the thymus of transgenic male Hcls1-null mice, significant numbers of double positive thymocytes do not undergo negative selection and remain undeleted

decreased double-positive T cell number ( J:28146 )

• in Hcls1-expressing transgenic male mice, the population of double positive thymocytes is reduced to 10% of that in female ransgenic Hcls1-expressing animals

Allelic Composition	H2^b/H2^b Ptcra^tm1Vbo/Ptcra^tm1Vbo Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^b mutation (28 available); any H2 mutation (280 available)
Ptcra^tm1Vbo mutation (0 available); any Ptcra mutation (16 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T cell differentiation ( J:131357 )

• the presence of HY TCR alleviates the beta-selection block of developing T cells found in Ptcra^tm1Vbo homozygotes resulting in higher T cell numbers being found in the thymus and the spleen

• the presence of the selecting H2^d allele contributes to the rescue of T cell development by the HY-TCR

• despite the increased numbers of thymocytes, the CD25⁺ thymocyte sub-population still remains very low

hematopoietic system

abnormal T cell differentiation ( J:131357 )

• the presence of HY TCR alleviates the beta-selection block of developing T cells found in Ptcra^tm1Vbo homozygotes resulting in higher T cell numbers being found in the thymus and the spleen

• the presence of the selecting H2^d allele contributes to the rescue of T cell development by the HY-TCR

• despite the increased numbers of thymocytes, the CD25⁺ thymocyte sub-population still remains very low

Allelic Composition	Tg(TcraH-Y,TcrbH-Y)71Vbo/0 Tnfrsf25^tm1Mjo/Tnfrsf25^tm1Mjo
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)
Tnfrsf25^tm1Mjo mutation (0 available); any Tnfrsf25 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal thymus morphology ( J:84536 )

• by 14 weeks of age, thymus is almost undetectable in ~50% of the animals

increased thymocyte number ( J:84536 )

• at 10 weeks, significant inhibition of negative selection is observed; however, substantial negative selection occurs, as male thymi contain 1/100 the number of cells found in females

abnormal negative T cell selection ( J:84536 )

• at 10 weeks, significant inhibition of negative selection is observed; however, substantial negative selection occurs, as male thymi contain 1/100 the number of cells found in females

• positive selection is not impaired

immune system

abnormal thymus morphology ( J:84536 )

• by 14 weeks of age, thymus is almost undetectable in ~50% of the animals

increased thymocyte number ( J:84536 )

• at 10 weeks, significant inhibition of negative selection is observed; however, substantial negative selection occurs, as male thymi contain 1/100 the number of cells found in females

abnormal negative T cell selection ( J:84536 )

• at 10 weeks, significant inhibition of negative selection is observed; however, substantial negative selection occurs, as male thymi contain 1/100 the number of cells found in females

• positive selection is not impaired

endocrine/exocrine glands

abnormal thymus morphology ( J:84536 )

• by 14 weeks of age, thymus is almost undetectable in ~50% of the animals

increased thymocyte number ( J:84536 )

• at 10 weeks, significant inhibition of negative selection is observed; however, substantial negative selection occurs, as male thymi contain 1/100 the number of cells found in females

Allelic Composition	Mcl1^tm1Yen/Mcl1^tm1Yen Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcl1^tm1Yen mutation (0 available); any Mcl1 mutation (33 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal double-positive T cell morphology ( J:146246 )

• mice have decreased numbers of double positive thymocytes expressing the transgenic TCR

decreased CD8-positive, alpha-beta T cell number ( J:146246 )

• female mice have decreased frequency and numbers of transgenic CD8⁺ T cells in the thymus and in the periphery

hematopoietic system

abnormal double-positive T cell morphology ( J:146246 )

• mice have decreased numbers of double positive thymocytes expressing the transgenic TCR

decreased CD8-positive, alpha-beta T cell number ( J:146246 )

• female mice have decreased frequency and numbers of transgenic CD8⁺ T cells in the thymus and in the periphery

Allelic Composition	E2f2^tm1Zubi/E2f2^tm1Zubi Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background	involves: 129S1/Sv * C57BL/6 * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f2^tm1Zubi mutation (1 available); any E2f2 mutation (29 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:76318 )

• male mice die at 5 to 7 months of age after falling ill at 4 months of age whereas Tg(TcraH-Y,TcrbH-Y)71Vbo mice remain healthy and live at least 12 months

immune system

abnormal immune system morphology ( J:76318 )

thymus hypoplasia ( J:76318 )

• cell number within the thymus in male mice is decreased to a similar extent as in Tg(TcraH-Y,TcrbH-Y)71Vbo mice

• however, thymic negative selection is normal

enlarged spleen ( J:76318 )

• in male mice

increased CD8-positive, alpha-beta T cell number ( J:76318 )

• the proportion of H-Y-specific CD8+ T cells is increased 2- to 3-fold

abnormal immune system physiology ( J:76318 )

increased T cell proliferation ( J:76318 )

• Vbeta8+/CD8+ T cell proliferation is increased

increased susceptibility to autoimmune disorder ( J:76318 )

• at 5 months, male mice exhibit features of inflammatory/autoimmune disease that are more severe than those observed at 15 months in E2f2^tm1Zubi homozygotes

increased inflammatory response ( J:76318 )

• at 5 months, male mice exhibit features of inflammatory/autoimmune disease that are more severe than those observed at 15 months in E2f2^tm1Zubi homozygotes

hematopoietic system

increased T cell proliferation ( J:76318 )

• Vbeta8+/CD8+ T cell proliferation is increased

thymus hypoplasia ( J:76318 )

• cell number within the thymus in male mice is decreased to a similar extent as in Tg(TcraH-Y,TcrbH-Y)71Vbo mice

• however, thymic negative selection is normal

enlarged spleen ( J:76318 )

• in male mice

increased CD8-positive, alpha-beta T cell number ( J:76318 )

• the proportion of H-Y-specific CD8+ T cells is increased 2- to 3-fold

endocrine/exocrine glands

thymus hypoplasia ( J:76318 )

• cell number within the thymus in male mice is decreased to a similar extent as in Tg(TcraH-Y,TcrbH-Y)71Vbo mice

• however, thymic negative selection is normal

cellular

increased T cell proliferation ( J:76318 )

• Vbeta8+/CD8+ T cell proliferation is increased

growth/size/body

enlarged spleen ( J:76318 )

• in male mice

Allelic Composition	Itk^tm1Litt/Itk^tm1Litt Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itk^tm1Litt mutation (2 available); any Itk mutation (48 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal positive T cell selection ( J:31230 )

• decrease in efficiency of selection of CD4-CD8+ T3.70^hi thymocytes is observed

• number of CD4-CD8+ T cells in periphery bearing the clonotypic TCR is greatly reduced, while absolute numbers of CD4-CD8+ T cells is not different from controls

increased double-positive T cell number ( J:31230 )

• male mice show consistent increase in fraction of CD4+CD8+ thymocytes compared to controls, but total number of T cells is not different

decreased CD4-positive, alpha-beta T cell number ( J:31230 )

• number of CD4+ T cells in periphery of female mutants is reduced compared to Itk-heterozygous transgene expressing littermates

hematopoietic system

abnormal positive T cell selection ( J:31230 )

• decrease in efficiency of selection of CD4-CD8+ T3.70^hi thymocytes is observed

• number of CD4-CD8+ T cells in periphery bearing the clonotypic TCR is greatly reduced, while absolute numbers of CD4-CD8+ T cells is not different from controls

increased double-positive T cell number ( J:31230 )

• male mice show consistent increase in fraction of CD4+CD8+ thymocytes compared to controls, but total number of T cells is not different

decreased CD4-positive, alpha-beta T cell number ( J:31230 )

• number of CD4+ T cells in periphery of female mutants is reduced compared to Itk-heterozygous transgene expressing littermates

Allelic Composition	Cd8b1^tm1Litt/Cd8b1⁺ Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background	involves: 129S4/SvJae * C57BL/6J * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd8b1^tm1Litt mutation (1 available); any Cd8b1 mutation (20 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased double-positive T cell number ( J:112551 )

• male transgenic mice show disruption of relative and absolute numbers of double positive T cells in the thymus

immune system

decreased double-positive T cell number ( J:112551 )

• male transgenic mice show disruption of relative and absolute numbers of double positive T cells in the thymus

Allelic Composition	Cd8b1^tm1Litt/Cd8b1^tm1Litt Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background	involves: 129S4/SvJae * C57BL/6J * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd8b1^tm1Litt mutation (1 available); any Cd8b1 mutation (20 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal negative T cell selection ( J:112551 )

• mice show significant recovery of double positive cell numbers, indicating that negative selection is impaired

abnormal positive T cell selection ( J:112551 )

• thymocytes in female transgenic mice show a 20-fold reduction in CD4-CD8+ T cells compared to CD8b1^tm1Litt heterozygous transgenic mice showing defective positive selection

increased CD4-positive, alpha-beta T cell number ( J:112551 )

• there is an increase in mature CD4+ T cells in thymus

decreased CD8-positive, alpha-beta T cell number ( J:112551 )

• in peripheral lymphoid organs, a 7-fold reduction is observed

abnormal lymph node cell ratio ( J:112551 )

• lymph nodes in male mice have 50% higher CD3+ lymphocytes compared to heterozygous transgenic males

hematopoietic system

abnormal negative T cell selection ( J:112551 )

• mice show significant recovery of double positive cell numbers, indicating that negative selection is impaired

abnormal positive T cell selection ( J:112551 )

• thymocytes in female transgenic mice show a 20-fold reduction in CD4-CD8+ T cells compared to CD8b1^tm1Litt heterozygous transgenic mice showing defective positive selection

increased CD4-positive, alpha-beta T cell number ( J:112551 )

• there is an increase in mature CD4+ T cells in thymus

decreased CD8-positive, alpha-beta T cell number ( J:112551 )

• in peripheral lymphoid organs, a 7-fold reduction is observed

Allelic Composition	Zap70^tm2.1Weis/Zap70^tm2.1Weis Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background	involves: 129S4/SvJae * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)
Zap70^tm2.1Weis mutation (1 available); any Zap70 mutation (55 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal T cell clonal deletion ( J:154166 )

• a substantial number of double positive and CD8 single positive thymocytes develop in male mutant mice unlike in transgenic mice wild type for Zap70

• three fold increase in total numbers of thymocytes in male mice with a nearly 40-fold increase in double positive thymocytes

abnormal positive T cell selection ( J:154166 )

• there were substantially fewer CD8+ HY-TCR+ thymocytes in female mice

immune system

abnormal T cell clonal deletion ( J:154166 )

• a substantial number of double positive and CD8 single positive thymocytes develop in male mutant mice unlike in transgenic mice wild type for Zap70

• three fold increase in total numbers of thymocytes in male mice with a nearly 40-fold increase in double positive thymocytes

abnormal positive T cell selection ( J:154166 )

• there were substantially fewer CD8+ HY-TCR+ thymocytes in female mice

Allelic Composition	Tg(TcraH-Y,TcrbH-Y)71Vbo/? Themis^tm1Gasc/Themis^tm1Gasc
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)
Themis^tm1Gasc mutation (1 available); any Themis mutation (55 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal negative T cell selection ( J:151074 )

• the negative selection that normally occurs to transgenic thymocytes in male mice is incomplete in these mice with some single-positive thymocytes present in the thymus

abnormal positive T cell selection ( J:151074 )

• the positive selection that normally occurs to transgeneic thymocytes in female mice is incomplete in these mice with few CD8 T cells being generated

hematopoietic system

abnormal negative T cell selection ( J:151074 )

• the negative selection that normally occurs to transgenic thymocytes in male mice is incomplete in these mice with some single-positive thymocytes present in the thymus

abnormal positive T cell selection ( J:151074 )

• the positive selection that normally occurs to transgeneic thymocytes in female mice is incomplete in these mice with few CD8 T cells being generated

Allelic Composition	Lcp2^tm3Gak/Lcp2^tm3Gak Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lcp2^tm3Gak mutation (0 available); any Lcp2 mutation (41 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:132995 )

N	• the reduced thymic cellularity of mice carrying just the transgenic TCR is rescued when crossed to the Lcp2^tm3Gak homozygote background

abnormal negative T cell selection ( J:132995 )

• the block in development at the double negative stage for mice carrying just the transgene is substantially alleviated when crossed to the Lcp2^tm3Gak homozygote background

increased double-positive T cell number ( J:132995 )

• the number of double positive T cells in the thymus are increased compared to mice carrying just the transgenic TCR

increased CD8-positive, alpha-beta T cell number ( J:132995 )

• the number of CD8 single positive T cells in the thymus are increased compared to mice carrying just the transgenic TCR

hematopoietic system

abnormal negative T cell selection ( J:132995 )

• the block in development at the double negative stage for mice carrying just the transgene is substantially alleviated when crossed to the Lcp2^tm3Gak homozygote background

increased double-positive T cell number ( J:132995 )

• the number of double positive T cells in the thymus are increased compared to mice carrying just the transgenic TCR

increased CD8-positive, alpha-beta T cell number ( J:132995 )

• the number of CD8 single positive T cells in the thymus are increased compared to mice carrying just the transgenic TCR

Allelic Composition	Lcp2^tm4Gak/Lcp2^tm4Gak Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * DBA * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lcp2^tm4Gak mutation (0 available); any Lcp2 mutation (41 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal negative T cell selection ( J:132995 )

• the block in development at the double negative stage for mice carrying just the transgene is alleviated when crossed to the Lcp2^tm4Gak homozygote background

increased double-positive T cell number ( J:132995 )

• the number of double positive T cells in the thymus are increased compared to mice carrying just the transgenic TCR

hematopoietic system

abnormal negative T cell selection ( J:132995 )

• the block in development at the double negative stage for mice carrying just the transgene is alleviated when crossed to the Lcp2^tm4Gak homozygote background

increased double-positive T cell number ( J:132995 )

• the number of double positive T cells in the thymus are increased compared to mice carrying just the transgenic TCR

Allelic Composition	Cd8a^tm1Asin/Cd8a^tm1Asin Rag2^tm1Fwa/Rag2^tm1Fwa Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd8a^tm1Asin mutation (0 available); any Cd8a mutation (36 available)
Rag2^tm1Fwa mutation (48 available); any Rag2 mutation (117 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal CD8-positive, alpha beta T cell morphology ( J:125259 )

• CD8 expression on T cells from female mice is lower compared to T cells from female mutant mice that have wild-type Cd8a alleles

hematopoietic system

abnormal CD8-positive, alpha beta T cell morphology ( J:125259 )

• CD8 expression on T cells from female mice is lower compared to T cells from female mutant mice that have wild-type Cd8a alleles

Allelic Composition	Ets1^tm1Jml/Ets1^tm1Jml Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background	involves: 129S/SvEv * C57BL/6 * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets1^tm1Jml mutation (0 available); any Ets1 mutation (25 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:125056 )

N	• CD4+ cells do not express HY TCR

increased double-negative T cell number ( J:125056 )

decreased CD8-positive, alpha-beta T cell number ( J:125056 )

hematopoietic system

increased double-negative T cell number ( J:125056 )

decreased CD8-positive, alpha-beta T cell number ( J:125056 )

Allelic Composition	Rag2^tm1Fwa/Rag2^tm1Fwa Tg(TcraH-Y,TcrbH-Y)71Vbo/? Themis^5AT161/Themis^5AT161
Genetic Background	involves: 129S/SvEv * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag2^tm1Fwa mutation (48 available); any Rag2 mutation (117 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)
Themis^5AT161 mutation (0 available); any Themis mutation (55 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased single-positive T cell number ( J:151076 )

• CD8 single-positive thymocytes are reduced in female mice compared to transgenic controls

immune system

decreased single-positive T cell number ( J:151076 )

• CD8 single-positive thymocytes are reduced in female mice compared to transgenic controls

Allelic Composition	Rag2^tm1Fwa/Rag2^tm1Fwa Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background	involves: 129S/SvEv * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag2^tm1Fwa mutation (48 available); any Rag2 mutation (117 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal CD8-positive, alpha beta T cell morphology ( J:125259 )

• CD8 expression is reduced by 80% in male mice compared to female mice

• CD8 expression on T cells from male mice did not change when cultured in the presence of IL-7

abnormal CD8-positive, alpha-beta T cell physiology ( J:125259 )

• CD8 T cells from male mice are refractory to IL-7 signaling as assessed by decreased CD8 expression, increased IL-7 receptor alpha expression, and decreased Stat5 phosphorylation

• defects can be rescued in vitro by limiting cell to cell contact or in vivo by crossing with mice that express MHC alleles that do not present the HY antigen

abnormal cytotoxic T cell physiology ( J:66565 )

• female T cells respond to 10- to 100- fold less HY antigen than transgenic male T cells do

hematopoietic system

abnormal CD8-positive, alpha beta T cell morphology ( J:125259 )

• CD8 expression is reduced by 80% in male mice compared to female mice

• CD8 expression on T cells from male mice did not change when cultured in the presence of IL-7

abnormal CD8-positive, alpha-beta T cell physiology ( J:125259 )

• CD8 T cells from male mice are refractory to IL-7 signaling as assessed by decreased CD8 expression, increased IL-7 receptor alpha expression, and decreased Stat5 phosphorylation

• defects can be rescued in vitro by limiting cell to cell contact or in vivo by crossing with mice that express MHC alleles that do not present the HY antigen

abnormal cytotoxic T cell physiology ( J:66565 )

• female T cells respond to 10- to 100- fold less HY antigen than transgenic male T cells do

Allelic Composition	Elk4^tm1Rtr/Elk4^tm1Rtr Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background	involves: 129/Sv * C57BL/6 * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elk4^tm1Rtr mutation (0 available); any Elk4 mutation (17 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal positive T cell selection ( J:88515 )

• CD8 thymocyte positive selection is impaired; females show an approximate 80% reduction in CD8⁺ single-positive thymocyte numbers and 60% reduction in the proportion of TCR^hi cells

decreased CD8-positive, alpha-beta T cell number ( J:88515 )

• females show an approximate 80% reduction in CD8⁺ single-positive thymocyte numbers and 60% reduction in the proportion of TCR^hi cells

immune system

abnormal positive T cell selection ( J:88515 )

• CD8 thymocyte positive selection is impaired; females show an approximate 80% reduction in CD8⁺ single-positive thymocyte numbers and 60% reduction in the proportion of TCR^hi cells

decreased CD8-positive, alpha-beta T cell number ( J:88515 )

• females show an approximate 80% reduction in CD8⁺ single-positive thymocyte numbers and 60% reduction in the proportion of TCR^hi cells

Allelic Composition	Tg(Lck-FADD)1Hed/0 Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background	involves: BALB/c * C57BL/6J * C57L/J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Lck-FADD)1Hed mutation (1 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:100451 )

N	• HY mediated negative selection in this TCR transgenic model was not blocked or altered by the presence of Tg(Lck-FADD)1Hed

Allelic Composition	Zap70^m1Saka/Zap70^m1Saka Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background	involves: BALB/c * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)
Zap70^m1Saka mutation (1 available); any Zap70 mutation (55 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal positive T cell selection ( J:86607 )

• female mice show almost no positive selection for transgenic CD8+CD4- thymocytes and T cells

• male transgenic mice show efficient positive selection of transgenic CD8+CD4- thymocytes

immune system

abnormal positive T cell selection ( J:86607 )

• female mice show almost no positive selection for transgenic CD8+CD4- thymocytes and T cells

• male transgenic mice show efficient positive selection of transgenic CD8+CD4- thymocytes

arthritis ( J:86607 )

• mice develop arthritis with high incidence

skeleton

arthritis ( J:86607 )

• mice develop arthritis with high incidence

Allelic Composition	Lck^tm1Dbs/Lck^tm1Dbs Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background	involves: C3H * C57BL/6 * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lck^tm1Dbs mutation (0 available); any Lck mutation (93 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal T cell differentiation ( J:114660 )

abnormal positive T cell selection ( J:114660 )

• almost complete block of positive selection is observed

arrested T cell differentiation ( J:114660 )

• almost complete block of positive selection is observed

immune system

abnormal T cell differentiation ( J:114660 )

abnormal positive T cell selection ( J:114660 )

• almost complete block of positive selection is observed

arrested T cell differentiation ( J:114660 )

• almost complete block of positive selection is observed

Allelic Composition	Fbn1^Tsk/Fbn1⁺ Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background	involves: C57BL/10 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbn1^Tsk mutation (2 available); any Fbn1 mutation (171 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

integument phenotype ( J:57957 )

N	• no skin fibrosis develops

respiratory system

emphysema ( J:57957 )

• emphysema develops as expected for heterozygous Fbn1^Tsk

Allelic Composition	Tg(Lck-Stk17b)26.1Wals/? Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background	involves: C57BL/6 * C57BL/10

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Lck-Stk17b)26.1Wals mutation (1 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased thymocyte number ( J:149973 )

abnormal T cell differentiation ( J:149973 )

decreased CD8-positive, alpha-beta T cell number ( J:149973 )

• increased proportion of CD8+ thymocytes bearing H-Y clonotypic TCR

increased CD8-positive, alpha-beta T cell number ( J:149973 )

• reduction in the percentage of single positive CD8+ T cells observed in females reflecting impaired positive selection

immune system

decreased thymocyte number ( J:149973 )

abnormal T cell differentiation ( J:149973 )

decreased CD8-positive, alpha-beta T cell number ( J:149973 )

• increased proportion of CD8+ thymocytes bearing H-Y clonotypic TCR

increased CD8-positive, alpha-beta T cell number ( J:149973 )

• reduction in the percentage of single positive CD8+ T cells observed in females reflecting impaired positive selection

endocrine/exocrine glands

decreased thymocyte number ( J:149973 )

Allelic Composition	Lcp2^tm1.1Wz/Lcp2^tm1.1Wz Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background	involves: C57BL/6 * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lcp2^tm1.1Wz mutation (0 available); any Lcp2 mutation (41 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T cell differentiation ( J:150304 )

• thymic negative selection is impaired in male mice

• thymic positive selection is impaired in female mice

hematopoietic system

abnormal T cell differentiation ( J:150304 )

• thymic negative selection is impaired in male mice

• thymic positive selection is impaired in female mice

Allelic Composition	Ptpn22^tm1.1Kas/Ptpn22^tm1.1Kas Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background	involves: C57BL/6 * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptpn22^tm1.1Kas mutation (0 available); any Ptpn22 mutation (51 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:176519 )

N	• mice exhibit normal positive selection of thymic and peripheral T cells compared with wild-type mice

Allelic Composition	Tg(LCKprBCL2)36Sjk/0 Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background	involves: C57BL/6 * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(LCKprBCL2)36Sjk mutation (1 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased thymocyte apoptosis ( J:217939 )

• thymocyte apoptosis is inhibited in response to an HY TCR-specific peptide compared to controls which show massive apoptosis

abnormal T cell clonal deletion ( J:217939 )

• thymocytes are protected from apoptosis induced by an HY TCR-specific peptide indicating impaired clonal deletion

hematopoietic system

decreased thymocyte apoptosis ( J:217939 )

• thymocyte apoptosis is inhibited in response to an HY TCR-specific peptide compared to controls which show massive apoptosis

abnormal T cell clonal deletion ( J:217939 )

• thymocytes are protected from apoptosis induced by an HY TCR-specific peptide indicating impaired clonal deletion

endocrine/exocrine glands

decreased thymocyte apoptosis ( J:217939 )

• thymocyte apoptosis is inhibited in response to an HY TCR-specific peptide compared to controls which show massive apoptosis

cellular

decreased thymocyte apoptosis ( J:217939 )

• thymocyte apoptosis is inhibited in response to an HY TCR-specific peptide compared to controls which show massive apoptosis

Allelic Composition	Cd3e^tm1.1Geno/Cd3e^tm1.1Geno Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background	involves: C57BL/6 * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd3e^tm1.1Geno mutation (0 available); any Cd3e mutation (47 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased DN3 thymocyte number ( J:192604 )

abnormal negative T cell selection ( J:192604 )

• defects are detected in males

abnormal positive T cell selection ( J:192604 )

• defects are detected in females

hematopoietic system

increased DN3 thymocyte number ( J:192604 )

abnormal negative T cell selection ( J:192604 )

• defects are detected in males

abnormal positive T cell selection ( J:192604 )

• defects are detected in females

endocrine/exocrine glands

increased DN3 thymocyte number ( J:192604 )

Allelic Composition	Tg(Cd4-BCL2G101AD102A*D103A)AWnt/0 Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background	involves: C57BL/6 * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Cd4-BCL2*G101A*D102A*D103A)AWnt mutation (0 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased thymocyte apoptosis ( J:217939 )

• thymocyte apoptosis is inhibited in response to an HY TCR-specific peptide compared to controls which show massive apoptosis

abnormal T cell clonal deletion ( J:217939 )

• thymocytes are protected from apoptosis induced by an HY TCR-specific peptide indicating impaired clonal deletion

hematopoietic system

decreased thymocyte apoptosis ( J:217939 )

• thymocyte apoptosis is inhibited in response to an HY TCR-specific peptide compared to controls which show massive apoptosis

abnormal T cell clonal deletion ( J:217939 )

• thymocytes are protected from apoptosis induced by an HY TCR-specific peptide indicating impaired clonal deletion

endocrine/exocrine glands

decreased thymocyte apoptosis ( J:217939 )

• thymocyte apoptosis is inhibited in response to an HY TCR-specific peptide compared to controls which show massive apoptosis

cellular

decreased thymocyte apoptosis ( J:217939 )

• thymocyte apoptosis is inhibited in response to an HY TCR-specific peptide compared to controls which show massive apoptosis

Allelic Composition	Sit1^tm1Lsmn/Sit1^tm1Lsmn Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background	involves: C57BL/6 * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sit1^tm1Lsmn mutation (0 available); any Sit1 mutation (14 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T cell differentiation ( J:100408 )

• more efficient suppression of the rearrangement of the endogenous TCR-alpha chain

abnormal positive T cell selection ( J:100408 )

• enhanced positive selection of T cells and partial conversion of positive selection to negative selection

abnormal CD8-positive, alpha beta T cell morphology ( J:100408 )

• CD8 single positive cells are more mature

hematopoietic system

abnormal T cell differentiation ( J:100408 )

• more efficient suppression of the rearrangement of the endogenous TCR-alpha chain

abnormal positive T cell selection ( J:100408 )

• enhanced positive selection of T cells and partial conversion of positive selection to negative selection

abnormal CD8-positive, alpha beta T cell morphology ( J:100408 )

• CD8 single positive cells are more mature

Allelic Composition	Tg(Cd8aCd8b)3Erob/0 Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background	involves: C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Cd8aCd8b)3Erob mutation (1 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal CD8-positive, alpha-beta T cell differentiation ( J:93004 )

• there is a 5-6 fold increase in the thymocyte population that is CD4^- CD8.2⁺ (i.e. positive for the endogenous CD8 complex)

• among thymocytes expressing the transgenic TCR, the skewing of the CD4:CD8 ratio is 1:50

• there is a 2-fold decrease in the number of CD4⁺ T cells that express the transgenic TCR compared to controls that do not carry the Tg(Cd8aCd8b)3Erob transgene

increased CD8-positive, alpha-beta T cell number ( J:93004 )

• the CD8 transgene further skews differentiation of T cells expressing the transgenic TCR into the CD8 T cell lineage

abnormal CD4-positive, alpha beta T cell morphology ( J:93004 )

• there is a 2-fold decrease in the number of CD4⁺ T cells that express the transgenic TCR compared to controls that do not carry the Tg(Cd8aCd8b)3Erob transgene

hematopoietic system

abnormal CD8-positive, alpha-beta T cell differentiation ( J:93004 )

• there is a 5-6 fold increase in the thymocyte population that is CD4^- CD8.2⁺ (i.e. positive for the endogenous CD8 complex)

• among thymocytes expressing the transgenic TCR, the skewing of the CD4:CD8 ratio is 1:50

• there is a 2-fold decrease in the number of CD4⁺ T cells that express the transgenic TCR compared to controls that do not carry the Tg(Cd8aCd8b)3Erob transgene

increased CD8-positive, alpha-beta T cell number ( J:93004 )

• the CD8 transgene further skews differentiation of T cells expressing the transgenic TCR into the CD8 T cell lineage

abnormal CD4-positive, alpha beta T cell morphology ( J:93004 )

• there is a 2-fold decrease in the number of CD4⁺ T cells that express the transgenic TCR compared to controls that do not carry the Tg(Cd8aCd8b)3Erob transgene

Allelic Composition	Tg(CD2-Zbtb7b)C8Rbo/? Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background	involves: C57BL/6 * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CD2-Zbtb7b)C8Rbo mutation (0 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T cell differentiation ( J:97610 )

• female mice have substantial numbers of HY-specific CD4⁺ T cells while having a complete absence of HY-specific CD8⁺ T cells, which is a reversal of the T cell populations that normally develop in female mice carrying just the Tg(TcraH-Y,TcrbH-Y)71Vbo allele

hematopoietic system

abnormal T cell differentiation ( J:97610 )

Allelic Composition	Gimap5^m1Btlr/Gimap5^m1Btlr Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background	involves: C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gimap5^m1Btlr mutation (1 available); any Gimap5 mutation (13 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased thymocyte number ( J:160090 )

• the number of H-Y-reactive thymocytes is decreased compared to in Tg(TcraH-Y,TcrbH-Y)71Vbo mice

• the number of H-Y TCR+ CD8+ thymocytes is decreased compared to in Tg(TcraH-Y,TcrbH-Y)71Vbo mice

• however, the number of H-Y TCR+ double positive thymocytes is normal

decreased CD8-positive, alpha-beta T cell number ( J:160090 )

• the number of H-Y TCR+ CD8+ thymocytes is decreased compared to in Tg(TcraH-Y,TcrbH-Y)71Vbo mice

immune system

decreased thymocyte number ( J:160090 )

• the number of H-Y-reactive thymocytes is decreased compared to in Tg(TcraH-Y,TcrbH-Y)71Vbo mice

• the number of H-Y TCR+ CD8+ thymocytes is decreased compared to in Tg(TcraH-Y,TcrbH-Y)71Vbo mice

• however, the number of H-Y TCR+ double positive thymocytes is normal

decreased CD8-positive, alpha-beta T cell number ( J:160090 )

• the number of H-Y TCR+ CD8+ thymocytes is decreased compared to in Tg(TcraH-Y,TcrbH-Y)71Vbo mice

endocrine/exocrine glands

decreased thymocyte number ( J:160090 )

• the number of H-Y-reactive thymocytes is decreased compared to in Tg(TcraH-Y,TcrbH-Y)71Vbo mice

• the number of H-Y TCR+ CD8+ thymocytes is decreased compared to in Tg(TcraH-Y,TcrbH-Y)71Vbo mice

• however, the number of H-Y TCR+ double positive thymocytes is normal

Allelic Composition	Cd247^tm2.1Lov/Cd247^tm2.1Lov Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background	involves: C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd247^tm2.1Lov mutation (0 available); any Cd247 mutation (11 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal T cell differentiation ( J:192915 )

• thymocyte negative selection in response to ubiquitous male antigen is impaired, but not abrogated, compared to in control mice

immune system

abnormal T cell differentiation ( J:192915 )

• thymocyte negative selection in response to ubiquitous male antigen is impaired, but not abrogated, compared to in control mice

Allelic Composition	Rasgrp1^tm1.1Wz/Rasgrp1^tm1.1Wz Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background	involves: C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasgrp1^tm1.1Wz mutation (0 available); any Rasgrp1 mutation (55 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased double-positive T cell number ( J:225109 )

• significantly elevated in males but normal CD8+ numbers

decreased single-positive T cell number ( J:225109 )

• reduced CD8+ numbers in females

hematopoietic system

increased double-positive T cell number ( J:225109 )

• significantly elevated in males but normal CD8+ numbers

decreased single-positive T cell number ( J:225109 )

• reduced CD8+ numbers in females

Allelic Composition	Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background	involves: C57BL/6 * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T cell differentiation ( J:97610 )

• female mice have substantial numbers of HY-specific CD8⁺ T cells but not HY-specific CD4⁺ T cells

abnormal cytotoxic T cell physiology ( J:66565 )

• virtually all CD8⁺ T cells from female mice recognize HY antigen in the context of H-2D^b

hematopoietic system

abnormal T cell differentiation ( J:97610 )

• female mice have substantial numbers of HY-specific CD8⁺ T cells but not HY-specific CD4⁺ T cells

abnormal cytotoxic T cell physiology ( J:66565 )

• virtually all CD8⁺ T cells from female mice recognize HY antigen in the context of H-2D^b

Allelic Composition	Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background	involves: C57BL/6J * C57L/J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

thymus hypoplasia ( J:79738 )

decreased thymocyte number ( J:79738 )

• males have a drastically reduced number of thymocytes, 0.5 1.6 x10⁷, due to massive deletion of double positive (CD4+CD8+) thymocytes; there are a normal number of double negative thymocytes, but they are the predominant cell type due to the deletion of the double positive population

abnormal T cell differentiation ( J:79738 , J:90776 )

• females have an increased proportion of CD4-CD8+ and CD4-CD8- thymocytes with a corrosponding decrease in the CD4+CD8+ population; greater than 95% of thymocytes in females and males express the transgenic Tcrb-V and the level of CD3 expression in males matches the higher values of the normal spectrum (J:79738)

• the Tcra and Tcrb transgenes are expressed in an appropriately tissue-specific fashion, but allelic exclusion by the transgenic Tcra is leaky, permitting endogenous rearrangement and expression in a minority of T cells; some male-derived T cell clones that respond to alloantigen were found to have excised the transgenic insertion (J:90776)

abnormal double-negative T cell morphology ( J:79738 )

• male lymph node T cells are 58% CD4-CD8-, 7% CD4+ CD8-, and 35% CD4-CD8+ but with low levels of CD8 expression and these CD4-CD8+ cells fail to respond to C57BL/6 males stimulator cells; female lymph node T cells have normal proportions of CD4 and CD8 expression and the CD4-CD8+ have a very high response rate to C57BL/6 male stimulator cells

hematopoietic system

thymus hypoplasia ( J:79738 )

decreased thymocyte number ( J:79738 )

abnormal T cell differentiation ( J:79738 , J:90776 )

abnormal double-negative T cell morphology ( J:79738 )

endocrine/exocrine glands

thymus hypoplasia ( J:79738 )

decreased thymocyte number ( J:79738 )

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