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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(ACTB-HSF1)1Anak
transgene insertion 1, Akira Nakai
MGI:3044263
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Hsf1tm1Anak/Hsf1tm1Anak
Tg(ACTB-HSF1)1Anak/?
involves: C57BL/6 * CBA * ICR MGI:3044360
tg2
Tg(ACTB-HSF1)1Anak/? involves: C57BL/6 * CBA MGI:3044363


Genotype
MGI:3044360
cx1
Allelic
Composition
Hsf1tm1Anak/Hsf1tm1Anak
Tg(ACTB-HSF1)1Anak/?
Genetic
Background
involves: C57BL/6 * CBA * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hsf1tm1Anak mutation (1 available); any Hsf1 mutation (16 available)
Tg(ACTB-HSF1)1Anak mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• diameter of seminiferous tubules is larger than in mice expressing endogenous Hsf1 as well as the transgene
• testis weight is low compared to normal controls but greater than in mice expressing endogenous Hsf1 as well as the transgene

reproductive system
N
• spermatogenesis is normal
• diameter of seminiferous tubules is larger than in mice expressing endogenous Hsf1 as well as the transgene
• testis weight is low compared to normal controls but greater than in mice expressing endogenous Hsf1 as well as the transgene




Genotype
MGI:3044363
tg2
Allelic
Composition
Tg(ACTB-HSF1)1Anak/?
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• spermatogenesis arrested at pachytene stage
• apoptosis in seminiferous tubules was common
• diameter of seminiferous tubules reduced about 20-30%
• testis weight about 42% of control weight
• only males are infertile

endocrine/exocrine glands
• diameter of seminiferous tubules reduced about 20-30%
• testis weight about 42% of control weight





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory