Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hsf1tm1Anak mutation
(1 available);
any
Hsf1 mutation
(25 available)
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reproductive system
N |
• homozygous males are fertile with testes of normal weight and histologically normal as well
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• apoptosis in seminiferous tubules of heat shocked testes was considerably reduced as compared to controls
• few late pachytene spermatocytes die as a result of heat stress
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hsf1tm1Anak mutation
(1 available);
any
Hsf1 mutation
(25 available)
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vision/eye
N |
• no cataracts are seen and lens epithelial cell morphology is normal
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hsf1tm1Anak mutation
(1 available);
any
Hsf1 mutation
(25 available)
Tg(ACTB-HSF1)1Anak mutation
(0 available)
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endocrine/exocrine glands
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• diameter of seminiferous tubules is larger than in mice expressing endogenous Hsf1 as well as the transgene
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• testis weight is low compared to normal controls but greater than in mice expressing endogenous Hsf1 as well as the transgene
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reproductive system
N |
• spermatogenesis is normal
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• diameter of seminiferous tubules is larger than in mice expressing endogenous Hsf1 as well as the transgene
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• testis weight is low compared to normal controls but greater than in mice expressing endogenous Hsf1 as well as the transgene
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vision/eye
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• the lens capsule is always ruptured; however, lens epithelial cell proliferation and morphology are fairly normal unlike in Hsf4tm1Anak homozygotes
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• more severe cataracts are seen compared to Hsf4tm1Anak homozygotes
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