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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tfectm1Est
targeted mutation 1, Eirikur Steingrimsson
MGI:3044120
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tfectm1Est/Tfectm1Est either: (involves: 129/Sv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J) MGI:3044233
cx2
 		MitfMi-wh/MitfMi-wh
Tfectm1Est/Tfectm1Est 		either: (involves: 129/Sv * 129S1/Sv * C57BL * DBA) or (involves: 129S1/Sv * C57BL * C57BL/6J * DBA) MGI:3044429
cx3
 		MitfMi-wh/MitfMi-wh
Tfe3tm1Est/Tfe3tm1Est
Tfectm1Est/Tfectm1Est 		either: (involves: 129/Sv * 129S1/Sv * C57BL * DBA) or (involves: 129S1/Sv * C57BL * C57BL/6J * DBA) MGI:4455023
cx4
 		MitfMi/MitfMi
Tfectm1Est/Tfectm1Est 		either: (involves: 129/Sv * 129S1/Sv * C57BL/6J) or (involves: 129S1/Sv * C57BL/6J) MGI:4455021
cx5
 		Tfe3tm1Est/Tfe3tm1Est
Tfectm1Est/Tfectm1Est 		either: (involves: 129/Sv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J) MGI:3044234
cx6
 		Tfebtm1Est/Tfeb+
Tfectm1Est/Tfectm1Est 		either: (involves: 129/Sv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J) MGI:4455031


Genotype
MGI:3044233
hm1
Allelic
Composition		 Tfectm1Est/Tfectm1Est
Genetic
Background		 either: (involves: 129/Sv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tfectm1Est mutation (0 available); any Tfec mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:89821 )
• mice were indistinguishable from their wild-type littermates; exhibiting normal eyes, pigment, mast cells, osteoclasts and placentas




Genotype
MGI:3044429
cx2
Allelic
Composition		 MitfMi-wh/MitfMi-wh
Tfectm1Est/Tfectm1Est
Genetic
Background		 either: (involves: 129/Sv * 129S1/Sv * C57BL * DBA) or (involves: 129S1/Sv * C57BL * C57BL/6J * DBA)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MitfMi-wh mutation (8 available); any Mitf mutation (72 available)
Tfectm1Est mutation (0 available); any Tfec mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation

skeleton
skeleton phenotype ( J:89821 )
N
• osteopetrosis is not observed amd bone development appears normal

vision/eye

integument




Genotype
MGI:4455023
cx3
Allelic
Composition		 MitfMi-wh/MitfMi-wh
Tfe3tm1Est/Tfe3tm1Est
Tfectm1Est/Tfectm1Est
Genetic
Background		 either: (involves: 129/Sv * 129S1/Sv * C57BL * DBA) or (involves: 129S1/Sv * C57BL * C57BL/6J * DBA)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MitfMi-wh mutation (8 available); any Mitf mutation (72 available)
Tfe3tm1Est mutation (1 available); any Tfe3 mutation (21 available)
Tfectm1Est mutation (0 available); any Tfec mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation

skeleton
osteopetrosis ( J:89821 )
• mice develop osteopetrosis similar to that observed in double MitfMi-wh and Tcfe3tm1Est mutants

vision/eye

integument




Genotype
MGI:4455021
cx4
Allelic
Composition		 MitfMi/MitfMi
Tfectm1Est/Tfectm1Est
Genetic
Background		 either: (involves: 129/Sv * 129S1/Sv * C57BL/6J) or (involves: 129S1/Sv * C57BL/6J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MitfMi mutation (3 available); any Mitf mutation (72 available)
Tfectm1Est mutation (0 available); any Tfec mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation

skeleton

vision/eye

integument




Genotype
MGI:3044234
cx5
Allelic
Composition		 Tfe3tm1Est/Tfe3tm1Est
Tfectm1Est/Tfectm1Est
Genetic
Background		 either: (involves: 129/Sv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tfe3tm1Est mutation (1 available); any Tfe3 mutation (21 available)
Tfectm1Est mutation (0 available); any Tfec mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:89821 )
• mice were indistinguishable from their wild-type littermates; exhibiting normal eyes, pigment, mast cells, osteoclasts and placentas




Genotype
MGI:4455031
cx6
Allelic
Composition		 Tfebtm1Est/Tfeb+
Tfectm1Est/Tfectm1Est
Genetic
Background		 either: (involves: 129/Sv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tfebtm1Est mutation (0 available); any Tfeb mutation (45 available)
Tfectm1Est mutation (0 available); any Tfec mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:89821 )
• mice exhibit normal eyes, pigment, mast cells, and osteoclasts




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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory