Phenotypes associated with this allele

• Allele Symbol: Del(11Jmjd6-Mettl23)1Ysfk
• Allele Name: deletion, Chr 11, Yoshinori Fukui 1
• Allele ID: MGI:3043930
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Del(11Jmjd6-Mettl23)1Ysfk/Del(11Jmjd6-Mettl23)1Ysfk	involves: C57BL/6	MGI:3043932

Genotype
MGI:3043932

hm1

• Allelic Composition: Del(11Jmjd6-Mettl23)1Ysfk/Del(11Jmjd6-Mettl23)1Ysfk
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:90288 )

• those pups that are born alive die within 24 hours

cellular

abnormal apoptosis ( J:90288 )

• apoptosis is repressed in several tissues including the liver and thymus but not in the intestine

impaired macrophage chemotaxis ( J:90288 )

• fewer F4/80⁺ macrophages are found in the thymus and liver compared to wild-type mice

impaired macrophage phagocytosis ( J:90288 )

• more unphagocytosed apoptotic cells are found in the liver at E13.5 and in the thymus at E16.5 despite an overall decrease in the number of apoptotic cells

growth/size/body

decreased fetal size ( J:90288 )

• at E15.5 mutant embryos are smaller than their heterozygous littermates

hematopoietic system

impaired macrophage chemotaxis ( J:90288 )

• fewer F4/80⁺ macrophages are found in the thymus and liver compared to wild-type mice

impaired macrophage phagocytosis ( J:90288 )

• more unphagocytosed apoptotic cells are found in the liver at E13.5 and in the thymus at E16.5 despite an overall decrease in the number of apoptotic cells

abnormal thymus development ( J:90288 )

• both the cortex and medulla are poorly developed

thymus hypoplasia ( J:90288 )

• at E18.5 the total number of thymocytes is decreased to less than 20% of wild-type

• fewer than 15% of these cells are CD4⁺CD8⁺ compared to more than 60% in wild-type mice indicating a block in thymocyte differentiation at the CD4^-CD8^- stage

abnormal erythropoiesis ( J:90288 )

• at E16.5 peripheral blood contains mainly larger nucleated erythrocytes derived primitive erythropoeisis in the yolk sac rather than smaller , enucleated erythrocytes derived from definitive erythropoeisis as in wild-type mice

• at E13.5 the proportion of Ter119⁺c-kit^- erythroid cells in the liver significantly decreased while the number of Ter119⁺c-kit⁺ was unchanged indicating a block in erythroid differentiation at an early erythroblast stage

decreased hematocrit ( J:90288 )

• at E16.5 hematocrit is greatly reduced

decreased hemoglobin content ( J:90288 )

• at E16.5 hemoglobin concentration is greatly reduced

increased nucleated erythrocyte cell number ( J:90288 )

• at E16.5 peripheral blood contains mainly larger nucleated erythrocytes derived primitive erythropoeisis in the yolk sac rather than smaller , enucleated erythrocytes derived from definitive erythropoeisis as in wild-type mice

immune system

impaired macrophage chemotaxis ( J:90288 )

• fewer F4/80⁺ macrophages are found in the thymus and liver compared to wild-type mice

impaired macrophage phagocytosis ( J:90288 )

• more unphagocytosed apoptotic cells are found in the liver at E13.5 and in the thymus at E16.5 despite an overall decrease in the number of apoptotic cells

abnormal thymus development ( J:90288 )

• both the cortex and medulla are poorly developed

thymus hypoplasia ( J:90288 )

• at E18.5 the total number of thymocytes is decreased to less than 20% of wild-type

• fewer than 15% of these cells are CD4⁺CD8⁺ compared to more than 60% in wild-type mice indicating a block in thymocyte differentiation at the CD4^-CD8^- stage

liver/biliary system

liver hypoplasia ( J:90288 )

• at E13.5 the total number of liver cells is decreased to less than 20% of wild-type

endocrine/exocrine glands

abnormal thymus development ( J:90288 )

• both the cortex and medulla are poorly developed

thymus hypoplasia ( J:90288 )

• at E18.5 the total number of thymocytes is decreased to less than 20% of wild-type

• fewer than 15% of these cells are CD4⁺CD8⁺ compared to more than 60% in wild-type mice indicating a block in thymocyte differentiation at the CD4^-CD8^- stage