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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Hand1tm1Cse
targeted mutation 1, Peter Cserjesi
MGI:3042297
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Hand1tm1Cse/Hand1tm1Cse either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster) MGI:3042299
hm2
Hand1tm1Cse/Hand1tm1Cse involves: 129S1/Sv MGI:3042298


Genotype
MGI:3042299
hm1
Allelic
Composition
Hand1tm1Cse/Hand1tm1Cse
Genetic
Background
either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hand1tm1Cse mutation (0 available); any Hand1 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• on a mixed 129S1/Sv and C57BL/6 or Swiss Webster background embryos are reabsorbed starting after E7.75 with a large number surviving up to E9.5

embryo
• on E9.5 the endoderm of the yolk sac is folded and gaps are seen between the endodermal and mesodermal layers of the yolk sac in homozygous mutants
• mature blood vessels are absent from homozygous yolk sacs on E8.5 - E9.5, however formation of the immature vascular plexus and hematopoiesis are normal
• on E8.5 - E9.5 smooth muscle cell recruitment to the vasculature is impaired in yolk sacs from homozygous mutants




Genotype
MGI:3042298
hm2
Allelic
Composition
Hand1tm1Cse/Hand1tm1Cse
Genetic
Background
involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hand1tm1Cse mutation (0 available); any Hand1 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• on an inbred 129S1/Sv background embryos are reabsorbed at E7.5





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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory