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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mapk3tm1Gela
targeted mutation 1, Gary E Landreth
MGI:3042006
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mapk3tm1Gela/Mapk3tm1Gela 129(Cg)-Mapk3tm1Gela MGI:3042013
hm2
 		Mapk3tm1Gela/Mapk3tm1Gela either: 129(Cg)-Mapk3tm1Gela or B6.129-Mapk3tm1Gela MGI:3624362
hm3
 		Mapk3tm1Gela/Mapk3tm1Gela involves: 129S1/Sv * 129X1/SvJ MGI:5659951
hm4
 		Mapk3tm1Gela/Mapk3tm1Gela involves: 129S1/SvImJ MGI:3805516
cn5
 		Mapk1tm1Gela/Mapk1tm1Gela
Mapk3tm1Gela/Mapk3+
H2az2Tg(Wnt1-cre)11Rth/H2az2+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J MGI:5660196
cn6
 		Mapk1tm1Gela/Mapk1tm1Gela
Mapk3tm1Gela/Mapk3tm1Gela
H2az2Tg(Wnt1-cre)11Rth/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J MGI:5660197


Genotype
MGI:3042013
hm1
Allelic
Composition		 Mapk3tm1Gela/Mapk3tm1Gela
Genetic
Background		 129(Cg)-Mapk3tm1Gela
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk3tm1Gela mutation (1 available); any Mapk3 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
increased locomotor activity ( J:77455 )
• mutant mice have a tendency to be more active in the open field than wild-type mice but are otherwise normal, healthy and fertile

nervous system
nervous system phenotype ( J:89787 )
N
• mutant mice have normal long term potentiation response to theta burst stimulation




Genotype
MGI:3624362
hm2
Allelic
Composition		 Mapk3tm1Gela/Mapk3tm1Gela
Genetic
Background		 either: 129(Cg)-Mapk3tm1Gela or B6.129-Mapk3tm1Gela
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk3tm1Gela mutation (1 available); any Mapk3 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal cytokine secretion ( J:107504 )
• nulls on the 129 background show increased Ag-induced production of Il17 and decreased Il5 production compared to wild-type 129 mice
increased susceptibility to experimental autoimmune encephalomyelitis ( J:107504 )
• in the MOG35-55 induced model of EAE, Mapk3-deficient mice and controls of either background show susceptibility to EAE; knockouts on the 129 background show increased susceptibility compared to 129 control mice
• inflammation is mildly increased in Erk1-deficient mice on the 129 background compared to 129 controls




Genotype
MGI:5659951
hm3
Allelic
Composition		 Mapk3tm1Gela/Mapk3tm1Gela
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk3tm1Gela mutation (1 available); any Mapk3 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:144862 )
N
• mice are viable

embryo
embryo phenotype ( J:144862 )
N
• mice develop normally




Genotype
MGI:3805516
hm4
Allelic
Composition		 Mapk3tm1Gela/Mapk3tm1Gela
Genetic
Background		 involves: 129S1/SvImJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk3tm1Gela mutation (1 available); any Mapk3 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:137882 )
N
• cerebral cortex morphology (cellular density, thickness, laminar organization) is not different from controls




Genotype
MGI:5660196
cn5
Allelic
Composition		 Mapk1tm1Gela/Mapk1tm1Gela
Mapk3tm1Gela/Mapk3+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Mapk1tm1Gela mutation (1 available); any Mapk1 mutation (40 available)
Mapk3tm1Gela mutation (1 available); any Mapk3 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
cleft palate ( J:144862 )
• more severe than in mice with normal Mapk3
absent tongue ( J:144862 )

craniofacial
mandible hypoplasia ( J:144862 )
• more severe than in mice with normal Mapk3
short maxilla ( J:144862 )
• more severe than in mice with normal Mapk3
cleft palate ( J:144862 )
• more severe than in mice with normal Mapk3

cardiovascular system
persistent truncus arteriosus ( J:144862 )
• in 3 of 3 mice at E16.5 and E17.5
ventricular septal defect ( J:144862 )
• in 3 of 3 mice at E16.5 and E17.5

endocrine/exocrine glands
abnormal thymus morphology ( J:144862 )
• single-lobed, fused and misplaced
abnormal thyroid gland morphology ( J:144862 )
• singled-lobed and medially localized

digestive/alimentary system
cleft palate ( J:144862 )
• more severe than in mice with normal Mapk3

hematopoietic system
abnormal thymus morphology ( J:144862 )
• single-lobed, fused and misplaced

immune system
abnormal thymus morphology ( J:144862 )
• single-lobed, fused and misplaced

skeleton
mandible hypoplasia ( J:144862 )
• more severe than in mice with normal Mapk3
short maxilla ( J:144862 )
• more severe than in mice with normal Mapk3

vision/eye




Genotype
MGI:5660197
cn6
Allelic
Composition		 Mapk1tm1Gela/Mapk1tm1Gela
Mapk3tm1Gela/Mapk3tm1Gela
H2az2Tg(Wnt1-cre)11Rth/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Mapk1tm1Gela mutation (1 available); any Mapk1 mutation (40 available)
Mapk3tm1Gela mutation (1 available); any Mapk3 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
short maxilla ( J:144862 )
• more severe than in mice heterozygous for Mapk3tm1Gela

growth/size/body
absent tongue ( J:144862 )
absent outer ear ( J:144862 )
decreased body length ( J:144862 )

cardiovascular system
persistent truncus arteriosus ( J:144862 )
• in 5 of 5 mice at E16.5 and E17.5
ventricular septal defect ( J:144862 )
• in 5 of 5 mice at E16.5 and E17.5

endocrine/exocrine glands
abnormal thyroid gland morphology ( J:144862 )
• singled-lobed and medially localized

digestive/alimentary system

embryo

hearing/vestibular/ear

hematopoietic system

immune system

skeleton
short maxilla ( J:144862 )
• more severe than in mice heterozygous for Mapk3tm1Gela

vision/eye




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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory