About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Sox9tm2.1Crm
targeted mutation 2.1, Benoit de Crombrugghe
MGI:3041881
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Sox9tm2.1Crm/Sox9tm2.1Crm involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * C57BL/6J MGI:3719088
cx2
Sox8tm1Weg/Sox8tm1Weg
Sox9tm2.1Crm/Sox9+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * C57BL/6J MGI:3719087


Genotype
MGI:3719088
hm1
Allelic
Composition
Sox9tm2.1Crm/Sox9tm2.1Crm
Genetic
Background
involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox9tm2.1Crm mutation (0 available); any Sox9 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die at E11.5 due to cardiac failure

reproductive system
• no sex chords form in XY mice

cardiovascular system
• mice die at E11.5 due to cardiac failure




Genotype
MGI:3719087
cx2
Allelic
Composition
Sox8tm1Weg/Sox8tm1Weg
Sox9tm2.1Crm/Sox9+
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox8tm1Weg mutation (0 available); any Sox8 mutation (14 available)
Sox9tm2.1Crm mutation (0 available); any Sox9 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• at E15.5, male mice have fewer seminiferous tubules
• 3 of 3 mice exhibit abnormal sex chord development and a clearly outlined coelomic vessel
• at E15.5, male mice have areas resembling an ovary

endocrine/exocrine glands
• at E15.5, male mice have fewer seminiferous tubules





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/11/2018
MGI 6.12
The Jackson Laboratory