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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mettm1Sst
targeted mutation 1, Snorri S Thorgeirsson
MGI:3041135
Summary 11 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Mettm1Sst/Mettm1Sst involves: 129P2/OlaHsd * C57BL/6 MGI:3041260
cn2
Mettm1Sst/Mettm1Sst
Tg(SFTPC-rtTA)5Jaw/0
Tg(tetO-cre)1Jaw/0
involves: 129 * 129P2/OlaHsd * C57BL/6 MGI:4938180
cn3
Mettm1Sst/Mettm1Sst
Trp53tm1Brn/Trp53tm1Brn
involves: 129P2/OlaHsd MGI:5293779
cn4
Mettm1Cpo/Mettm1Sst
Tg(Nes-cre)1Kln/?
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL MGI:5052134
cn5
Mettm1Cpo/Mettm1Sst
Tg(Nes-cre)1Kln/0
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:5285657
cn6
Mettm1Sst/Mettm1Sst
Trp53tm1Brn/Trp53tm3Tyj
involves: 129P2/OlaHsd * 129S4/SvJae MGI:5293785
cn7
Mettm1Sst/Mettm1Sst
Trp53tm1Brn/Trp53tm2Tyj
involves: 129P2/OlaHsd * 129S4/SvJae MGI:5293786
cn8
Mettm1Sst/Mettm1Sst
Tg(Alb-cre)21Mgn/0
involves: 129P2/OlaHsd * C57BL/6 MGI:3041261
cn9
Mettm1Sst/Mettm1Sst
Tg(Pdx1-cre)89.1Dam/0
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:5504390
cn10
Mettm1Ics/Mettm1Sst
Tg(Nes-cre)1Kln/0
involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:5285658
cn11
Mettm1Sst/Mettm1Sst
Tg(mI56i-cre,EGFP)1Kc/0
involves: 129P2/OlaHsd * C57BL/6J * FVB MGI:4950068


Genotype
MGI:3041260
hm1
Allelic
Composition
Mettm1Sst/Mettm1Sst
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mettm1Sst mutation (1 available); any Met mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• homozygotes are viable, fertile, grow at a normal rate, and show no histological or physiological abnormalities at >1 year of age (J:89236)
• homozygotes are viable, fertile, grow at a normal rate, and show no histological or physiological abnormalities at >1 year of age (J:89236)




Genotype
MGI:4938180
cn2
Allelic
Composition
Mettm1Sst/Mettm1Sst
Tg(SFTPC-rtTA)5Jaw/0
Tg(tetO-cre)1Jaw/0
Genetic
Background
involves: 129 * 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mettm1Sst mutation (1 available); any Met mutation (1 available)
Tg(SFTPC-rtTA)5Jaw mutation (3 available)
Tg(tetO-cre)1Jaw mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• newborn mice exposed to doxycycline from E14.5 to birth display defective distal lung saccular development due to reduced primary septation (J:124125)
• newborn mice exposed to doxycycline from E14.5 to birth display defective distal lung saccular development due to reduced primary septation (J:124125)
• newborn mice exposed to doxycycline from E14.5 to birth display dilated distal airspaces with only few primary septae, unlike wild-type controls where extensive numbers of saccules are observed (J:124125)
• newborn mice exposed to doxycycline from E14.5 to birth display dilated distal airspaces with only few primary septae, unlike wild-type controls where extensive numbers of saccules are observed (J:124125)




Genotype
MGI:5293779
cn3
Allelic
Composition
Mettm1Sst/Mettm1Sst
Trp53tm1Brn/Trp53tm1Brn
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mettm1Sst mutation (1 available); any Met mutation (1 available)
Trp53tm1Brn mutation (6 available); any Trp53 mutation (142 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
N
• ovarian surface epithelium cells transfected with a cre-expressing adenovirus exhibit reduced invasion compared with cells from Trp53tm1Brn homozygotes transfected with a lacZ-expressing adenoviru (J:175978)
• ovarian surface epithelium cells transfected with a cre-expressing adenovirus exhibit reduced invasion compared with cells from Trp53tm1Brn homozygotes transfected with a lacZ-expressing adenoviru (J:175978)




Genotype
MGI:5052134
cn4
Allelic
Composition
Mettm1Cpo/Mettm1Sst
Tg(Nes-cre)1Kln/?
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mettm1Cpo mutation (0 available); any Met mutation (1 available)
Mettm1Sst mutation (1 available); any Met mutation (1 available)
Tg(Nes-cre)1Kln mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
N
• no effect on retinal ganglion cell survival after optic nerve axotomy (J:173661)
• no effect on retinal ganglion cell survival after optic nerve axotomy (J:173661)




Genotype
MGI:5285657
cn5
Allelic
Composition
Mettm1Cpo/Mettm1Sst
Tg(Nes-cre)1Kln/0
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mettm1Cpo mutation (0 available); any Met mutation (1 available)
Mettm1Sst mutation (1 available); any Met mutation (1 available)
Tg(Nes-cre)1Kln mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice exhibit reduced motor axon arborization (length and number of branches) in the pectoralis minor muscle compared with wild-type mice (J:174591)
• at P2, endplates in the pectoralis minor exhibit increased partially or completely denervated synapses compared with wild-type endplates (J:174591)
• however, mice exhibit normal innervation of the pectoralis minor muscle at E15.5 and of the pectoralis major (J:174591)
• mice exhibit reduced motor axon arborization (length and number of branches) in the pectoralis minor muscle compared with wild-type mice (J:174591)
• at P2, endplates in the pectoralis minor exhibit increased partially or completely denervated synapses compared with wild-type endplates (J:174591)
• however, mice exhibit normal innervation of the pectoralis minor muscle at E15.5 and of the pectoralis major (J:174591)
• by P2 in the C8 and T1 region of the spinal cord with no further reduction in adult mice (J:174591)
• by P2 in the C8 and T1 region of the spinal cord with no further reduction in adult mice (J:174591)
• mice exhibit reduced motor axon arborization (length and number of branches) in the pectoralis minor muscle compared with wild-type mice (J:174591)
• at P2, endplates in the pectoralis minor exhibit increased partially or completely denervated synapses compared with wild-type endplates (J:174591)
• however, mice exhibit normal innervation of the pectoralis minor muscle at E15.5 and of the pectoralis major (J:174591)
• mice exhibit reduced motor axon arborization (length and number of branches) in the pectoralis minor muscle compared with wild-type mice (J:174591)
• at P2, endplates in the pectoralis minor exhibit increased partially or completely denervated synapses compared with wild-type endplates (J:174591)
• however, mice exhibit normal innervation of the pectoralis minor muscle at E15.5 and of the pectoralis major (J:174591)

behavior/neurological
• in a wire hang test but not a rotarod (J:174591)
• in a wire hang test but not a rotarod (J:174591)




Genotype
MGI:5293785
cn6
Allelic
Composition
Mettm1Sst/Mettm1Sst
Trp53tm1Brn/Trp53tm3Tyj
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mettm1Sst mutation (1 available); any Met mutation (1 available)
Trp53tm1Brn mutation (6 available); any Trp53 mutation (142 available)
Trp53tm3Tyj mutation (2 available); any Trp53 mutation (142 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
N
• ovarian surface epithelium cells transfected with a cre-expressing adenovirus exhibit reduced invasion compared with similarly treated cells from Trp53tm1Brn/Trp53tm3Tyj mice (J:175978)
• ovarian surface epithelium cells transfected with a cre-expressing adenovirus exhibit reduced invasion compared with similarly treated cells from Trp53tm1Brn/Trp53tm3Tyj mice (J:175978)




Genotype
MGI:5293786
cn7
Allelic
Composition
Mettm1Sst/Mettm1Sst
Trp53tm1Brn/Trp53tm2Tyj
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mettm1Sst mutation (1 available); any Met mutation (1 available)
Trp53tm1Brn mutation (6 available); any Trp53 mutation (142 available)
Trp53tm2Tyj mutation (2 available); any Trp53 mutation (142 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
N
• ovarian surface epithelium cells transfected with a cre-expressing adenovirus exhibit reduced invasion compared with similarly treated cells from Trp53tm1Brn/Trp53tm2Tyj mice (J:175978)
• ovarian surface epithelium cells transfected with a cre-expressing adenovirus exhibit reduced invasion compared with similarly treated cells from Trp53tm1Brn/Trp53tm2Tyj mice (J:175978)




Genotype
MGI:3041261
cn8
Allelic
Composition
Mettm1Sst/Mettm1Sst
Tg(Alb-cre)21Mgn/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mettm1Sst mutation (1 available); any Met mutation (1 available)
Tg(Alb-cre)21Mgn mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
liver/biliary system
• mutants develop hemorrhagic liver destruction within the first few hours in response to apoptotic stimuli induced by Fas (Tnfrsf6) antibody compared to only minor liver damage in controls (J:89236)
• mutants develop hemorrhagic liver destruction within the first few hours in response to apoptotic stimuli induced by Fas (Tnfrsf6) antibody compared to only minor liver damage in controls (J:89236)
• primary hepatocytes show reduced phagocytic activity towards bacteria (E.coli) than control cells (J:89236)
• primary hepatocytes show reduced phagocytic activity towards bacteria (E.coli) than control cells (J:89236)
• hepatocytes exhibit increased sensitivity to Fas (Tnfrsf6)-induced apoptosis (J:89236)
• hepatocytes exhibit increased sensitivity to Fas (Tnfrsf6)-induced apoptosis (J:89236)
• the ability of mutant livers to clear necrotic tissue and to repopulate the injured (by CCl4 exposure) area by regenerating hepatocytes is impaired (J:89236)
• associated with a persistent inflammatory reaction, overproduction of osteopontin, early and prominent dystrophic calcification, and impaired hepatocyte scattering/migration into diseased areas (J:89236)
• the ability of mutant livers to clear necrotic tissue and to repopulate the injured (by CCl4 exposure) area by regenerating hepatocytes is impaired (J:89236)
• associated with a persistent inflammatory reaction, overproduction of osteopontin, early and prominent dystrophic calcification, and impaired hepatocyte scattering/migration into diseased areas (J:89236)
• 80% of mutants die of acute liver failure in response to apoptotic stimuli induced by Fas (Tnfrsf6) antibody while controls survive (J:89236)
• 80% of mutants die of acute liver failure in response to apoptotic stimuli induced by Fas (Tnfrsf6) antibody while controls survive (J:89236)

cardiovascular system
• mutants develop hemorrhagic liver destruction within the first few hours in response to apoptotic stimuli induced by Fas (Tnfrsf6) antibody compared to only minor liver damage in controls (J:89236)
• mutants develop hemorrhagic liver destruction within the first few hours in response to apoptotic stimuli induced by Fas (Tnfrsf6) antibody compared to only minor liver damage in controls (J:89236)

homeostasis/metabolism
• mutants exhibit delayed healing after toxic liver injury induced by CCl4 exposure (J:89236)
• mutants are more vulnerable to hepatectomy surgery and most are either moribund or die by 48 hours after surgery (J:89236)
• mutants exhibit delayed healing after toxic liver injury induced by CCl4 exposure (J:89236)
• mutants are more vulnerable to hepatectomy surgery and most are either moribund or die by 48 hours after surgery (J:89236)
• hepatocytes fail to migrate in a standard wound healing assay (J:89236)
• hepatocytes fail to migrate in a standard wound healing assay (J:89236)

cellular
• hepatocytes exhibit increased sensitivity to Fas (Tnfrsf6)-induced apoptosis (J:89236)
• hepatocytes exhibit increased sensitivity to Fas (Tnfrsf6)-induced apoptosis (J:89236)




Genotype
MGI:5504390
cn9
Allelic
Composition
Mettm1Sst/Mettm1Sst
Tg(Pdx1-cre)89.1Dam/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mettm1Sst mutation (1 available); any Met mutation (1 available)
Tg(Pdx1-cre)89.1Dam mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• islets from pregnant mutants do not exhibit an increase in insulin content as seen in pregnant wild-type females (J:196854)
• islets from pregnant mutants do not exhibit an increase in insulin content as seen in pregnant wild-type females (J:196854)
• pregnant females show decreased beta cell mass at gestational day 19 compared to controls, at a time when maximal beta-cell mass expansion occurs during pregnancy (J:196854)
• the decrease in beta-cell mass persists at postpartum day 4 (J:196854)
• however, islet number and beta-cell size are similar to wild-type at gestational day 19 (J:196854)
• pregnant females show decreased beta cell mass at gestational day 19 compared to controls, at a time when maximal beta-cell mass expansion occurs during pregnancy (J:196854)
• the decrease in beta-cell mass persists at postpartum day 4 (J:196854)
• however, islet number and beta-cell size are similar to wild-type at gestational day 19 (J:196854)
• apoptosis in beta-cells of mutant pregnant females is premature and is increased at gestational day 15, however at gestational day 19 and postpartum day 4, beta cell apoptosis is increased similarly in wild-type and mutant pregnant females (J:196854)
• mutant beta cells are more sensitive to the cytotoxic effects of a low dose of the synthetic hormone dexamethasone that does not induce cell death in wild-type islets (J:196854)
• apoptosis in beta-cells of mutant pregnant females is premature and is increased at gestational day 15, however at gestational day 19 and postpartum day 4, beta cell apoptosis is increased similarly in wild-type and mutant pregnant females (J:196854)
• mutant beta cells are more sensitive to the cytotoxic effects of a low dose of the synthetic hormone dexamethasone that does not induce cell death in wild-type islets (J:196854)
• pregnant females show a decrease in beta-cell proliferation at gestational day 15, when maximal beta-cell proliferation normally occurs during pregnancy (J:196854)
• beta-cell proliferation is also decreased at postpartum day 4 (J:196854)
• however, beta-cell proliferation is similar to wild-type at gestational day 11 and 19 (J:196854)
• pregnant females show a decrease in beta-cell proliferation at gestational day 15, when maximal beta-cell proliferation normally occurs during pregnancy (J:196854)
• beta-cell proliferation is also decreased at postpartum day 4 (J:196854)
• however, beta-cell proliferation is similar to wild-type at gestational day 11 and 19 (J:196854)
• islets from pregnant mutants do not exhibit an increase in insulin content as seen in pregnant wild-type females (J:196854)
• islets from mutant pregnant females do not exhibit an increase in glucose-stimulated insulin secretion at gestational day 19 that is seen in wild-type pregnant females (J:196854)
• islets from pregnant mutants do not exhibit an increase in insulin content as seen in pregnant wild-type females (J:196854)
• islets from mutant pregnant females do not exhibit an increase in glucose-stimulated insulin secretion at gestational day 19 that is seen in wild-type pregnant females (J:196854)

homeostasis/metabolism
• islets from pregnant mutants do not exhibit an increase in insulin content as seen in pregnant wild-type females (J:196854)
• islets from mutant pregnant females do not exhibit an increase in glucose-stimulated insulin secretion at gestational day 19 that is seen in wild-type pregnant females (J:196854)
• islets from pregnant mutants do not exhibit an increase in insulin content as seen in pregnant wild-type females (J:196854)
• islets from mutant pregnant females do not exhibit an increase in glucose-stimulated insulin secretion at gestational day 19 that is seen in wild-type pregnant females (J:196854)
• blood glucose is higher in pregnant mutant females at gestational day 19 than in wild-type pregnant females (J:196854)
• fasting blood glucose is increased in pregnant mutant females at gestational day 19 than in wild-type pregnant females (J:196854)
• blood glucose is higher in pregnant mutant females at gestational day 19 than in wild-type pregnant females (J:196854)
• fasting blood glucose is increased in pregnant mutant females at gestational day 19 than in wild-type pregnant females (J:196854)
• plasma insulin levels are diminished in pregnant mutant females at gestational day 19 compared to wild-type pregnant females (J:196854)
• plasma insulin levels are diminished in pregnant mutant females at gestational day 19 compared to wild-type pregnant females (J:196854)
• glucose tolerance is impaired more in pregnant mutant females than pregnant wild-type females at gestational day 15 and 19 and at postpartum day 4 (J:196854)
• pregnant mutant females respond similarly to insulin tolerance tests at gestational day 18 as wild-type females, indicating that enhanced impairment in glucose tolerance is not related to changes in insulin sensitivity (J:196854)
• glucose tolerance is impaired more in pregnant mutant females than pregnant wild-type females at gestational day 15 and 19 and at postpartum day 4 (J:196854)
• pregnant mutant females respond similarly to insulin tolerance tests at gestational day 18 as wild-type females, indicating that enhanced impairment in glucose tolerance is not related to changes in insulin sensitivity (J:196854)

cellular
• pregnant females show a decrease in beta-cell proliferation at gestational day 15, when maximal beta-cell proliferation normally occurs during pregnancy (J:196854)
• beta-cell proliferation is also decreased at postpartum day 4 (J:196854)
• however, beta-cell proliferation is similar to wild-type at gestational day 11 and 19 (J:196854)
• pregnant females show a decrease in beta-cell proliferation at gestational day 15, when maximal beta-cell proliferation normally occurs during pregnancy (J:196854)
• beta-cell proliferation is also decreased at postpartum day 4 (J:196854)
• however, beta-cell proliferation is similar to wild-type at gestational day 11 and 19 (J:196854)




Genotype
MGI:5285658
cn10
Allelic
Composition
Mettm1Ics/Mettm1Sst
Tg(Nes-cre)1Kln/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mettm1Ics mutation (0 available); any Met mutation (1 available)
Mettm1Sst mutation (1 available); any Met mutation (1 available)
Tg(Nes-cre)1Kln mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• by P2 with no further reduction in adult mice (J:174591)
• lacZ+ motor neurons are reduced at P2 in C8 and T1 regions of the spinal cord (J:174591)
• by P2 with no further reduction in adult mice (J:174591)
• lacZ+ motor neurons are reduced at P2 in C8 and T1 regions of the spinal cord (J:174591)




Genotype
MGI:4950068
cn11
Allelic
Composition
Mettm1Sst/Mettm1Sst
Tg(mI56i-cre,EGFP)1Kc/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mettm1Sst mutation (1 available); any Met mutation (1 available)
Tg(mI56i-cre,EGFP)1Kc mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• in the Morris water maze, mutants have a longer latency to locate the platform on the first 2 days of training than controls, however performance on the probe test and reversal probe test were normal, indicating normal hippocampal-mediated spatial learning (J:170554)
• open field activity and anxiety are not affected (J:170554)
• in the Morris water maze, mutants have a longer latency to locate the platform on the first 2 days of training than controls, however performance on the probe test and reversal probe test were normal, indicating normal hippocampal-mediated spatial learning (J:170554)
• open field activity and anxiety are not affected (J:170554)
• on reversal discriminations, mutants require more trials than controls, indicating impaired reversal learning (J:170554)
• on reversal discriminations, mutants require more trials than controls, indicating impaired reversal learning (J:170554)
• mutants show increased latency performance on the cued-platform test, indicating a delay in striatal-dependent cued learning (J:170554)
• mutants show increased latency performance on the cued-platform test, indicating a delay in striatal-dependent cued learning (J:170554)

nervous system
• marker analysis indicates an increase in numbers of PV+ and SST+ striatal GABAergic interneurons (J:170554)
• distribution of striatal interneurons is altered, with fewer cells of the population located in the medial (associative) regions and more cells in the lateral (sensorimotor) areas (J:170554)
• reduction in the numbers of PV+ GABAergic interneurons in the primary somatosensory cortex (28% loss) and the orbitofrontal cortex (31% loss) (J:170554)
• marker analysis indicates an increase in numbers of PV+ and SST+ striatal GABAergic interneurons (J:170554)
• distribution of striatal interneurons is altered, with fewer cells of the population located in the medial (associative) regions and more cells in the lateral (sensorimotor) areas (J:170554)
• reduction in the numbers of PV+ GABAergic interneurons in the primary somatosensory cortex (28% loss) and the orbitofrontal cortex (31% loss) (J:170554)
• marker analysis indicates an increase in numbers of PV+ and SST+ striatal GABAergic interneurons (J:170554)
• however, striatum appears normal (J:170554)
• marker analysis indicates an increase in numbers of PV+ and SST+ striatal GABAergic interneurons (J:170554)
• however, striatum appears normal (J:170554)
• 31% reduction in PV+ cells in the orbitofrontal cortex (J:170554)
• 31% reduction in PV+ cells in the orbitofrontal cortex (J:170554)
• 28% loss of PV+ cells in primary somatosensory cortex (J:170554)
• 28% loss of PV+ cells in primary somatosensory cortex (J:170554)





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory