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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nkx2-5tm2Siz
targeted mutation 2, Seigo Izumo
MGI:3040604
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Nkx2-5tm2Siz/Nkx2-5tm2Siz involves: 129S4/SvJaeSor MGI:3041123
ht2
Nkx2-5tm2Siz/Nkx2-5+ involves: 129S4/SvJaeSor MGI:3041124


Genotype
MGI:3041123
hm1
Allelic
Composition
Nkx2-5tm2Siz/Nkx2-5tm2Siz
Genetic
Background
involves: 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx2-5tm2Siz mutation (0 available); any Nkx2-5 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• death by E10 due to arrested cardiac development

cardiovascular system
• arrest of cardiac development at E9.5
• partial looping
• absence of the atrioventricular node primordium
• bulbous ventricle

muscle
• absence of the atrioventricular node primordium




Genotype
MGI:3041124
ht2
Allelic
Composition
Nkx2-5tm2Siz/Nkx2-5+
Genetic
Background
involves: 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx2-5tm2Siz mutation (0 available); any Nkx2-5 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• form a smaller central conduction system, with smaller atrioventricular node and His bundle
• the number of cells in the conduction system is reduced by approximately half
• hypocellularity of the peripheral Purkinje network
• smaller atrioventricular node
• defects in in the atrioventricular node, His bundle, and intraventricular conduction
• exhibit similar conduction and electrophysiologic abnormalities as heterozygous Nkx2-5tm1Siz mice

muscle
• form a smaller central conduction system, with smaller atrioventricular node and His bundle
• the number of cells in the conduction system is reduced by approximately half
• hypocellularity of the peripheral Purkinje network
• smaller atrioventricular node





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory