Phenotypes associated with this allele

• Allele Symbol: L1cam^tm1.1Vlem
• Allele Name: targeted mutation 1.1 Vance Lemmon
• Allele ID: MGI:3040294
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	L1cam^tm1.1Vlem/L1cam^tm1.1Vlem	129S2.Cg-L1cam^tm1.1Vlem	MGI:3041396
hm2	L1cam^tm1.1Vlem/L1cam^tm1.1Vlem	B6.Cg-L1cam^tm1.1Vlem	MGI:3041398

Genotype
MGI:3041396

hm1

• Allelic Composition: L1cam^tm1.1Vlem/L1cam^tm1.1Vlem
• Genetic Background: 129S2.Cg-L1cam^tm1.1Vlem

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:89300 )

♀ • on a 129/Sv genetic background, a slightly lower percentage of mutant males were born

nervous system

nervous system phenotype ( J:89300 )

♀N • no hydroencephaly or other morphological abnormalities of the brain or spinal cord were observed on a 129/Sv genetic background

Genotype
MGI:3041398

hm2

• Allelic Composition: L1cam^tm1.1Vlem/L1cam^tm1.1Vlem
• Genetic Background: B6.Cg-L1cam^tm1.1Vlem

mortality/aging

postnatal lethality, complete penetrance ( J:89300 )

♀ • Background Sensitivity: mice on a C57BL/6 genetic background that survived birth, died prior to P6

prenatal lethality, incomplete penetrance ( J:89300 )

♀ • Background Sensitivity: mice that had been backcrossed to the C57BL/6 genetic background for 5 to 9 generations showed increased embryonic lethality with only a small percentage of such mice surviving birth

nervous system

hydrocephaly ( J:89300 )

♀ • Background Sensitivity: severe hyrdroencephaly observed in mice on a C57BL/6 genetic background, but not in mice on a 129/Sv genetic background