Mouse Genome Informatics
tg1
    Tg(RIR-Tag)87Dh/0
involves: C57BL/6J * DBA/2J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• mutants die at 9-12 weeks of age; almost complete penetrance
• mutants placed on a high sugar diet to counteract hypoglycemia liver longer

endocrine/exocrine glands
• hyperplasia of the islets of Langerhans
• organization of alpha and delta cells is disrupted in islets
• reduced numbers of alpha cells in islets
• islets are densely packed with beta-cells
• reduced numbers of delta cells in islets

tumorigenesis
• mutants placed on a high sugar diet to counteract hypoglycemia develop solid pancreatic tumors between 10 and 20 weeks of age; tumors are pure beta-cell tumors
• no evidence that tumors metastasize other organs

homeostasis/metabolism

Mouse Models of Human Disease
OMIM IDRef(s)
Pancreatic Cancer 260350 J:50695