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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(RIR-Tag)87Dh
transgene insertion 87, Douglas Hanahan
MGI:3040264
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(RIR-Tag)87Dh/0 involves: C57BL/6J * DBA/2J MGI:5431967


Genotype
MGI:5431967
tg1
Allelic
Composition
Tg(RIR-Tag)87Dh/0
Genetic
Background
involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mutants die at 9-12 weeks of age; almost complete penetrance
• mutants placed on a high sugar diet to counteract hypoglycemia liver longer

endocrine/exocrine glands
• hyperplasia of the islets of Langerhans
• organization of alpha and delta cells is disrupted in islets
• reduced numbers of alpha cells in islets
• islets are densely packed with beta-cells
• reduced numbers of delta cells in islets
• mutants placed on a high sugar diet to counteract hypoglycemia develop solid pancreatic tumors between 10 and 20 weeks of age; tumors are pure beta-cell tumors
• no evidence that tumors metastasize other organs

neoplasm
• mutants placed on a high sugar diet to counteract hypoglycemia develop solid pancreatic tumors between 10 and 20 weeks of age; tumors are pure beta-cell tumors
• no evidence that tumors metastasize other organs

homeostasis/metabolism

Mouse Models of Human Disease
OMIM ID Ref(s)
Pancreatic Cancer 260350 J:50695





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory