Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1Rdp mutation
(6 available);
any
Cdkn2a mutation
(62 available)
Tg(tetO-Nras*Q61K)#Lc mutation
(0 available)
Tg(Tyr-rtTA)37Lc mutation
(1 available)
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integument
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• mice administered doxycycline at weaning develop spontaneous melanoma after an average of 15 weeks with a 50% penetrance
• withdrawal of doxycycline results in rapid, durable and complete tumor regression within 10 days
• doxycycline treated mice administered the MEK inhibitor Selumetinib or GSK1120212 show tumor stasis but not tumor regression
• doxycycline treated mice administered a selective inhibitor of CDK4/6, PD-0332991 together with either Selumetinib or GSK1120212 show tumor regression
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neoplasm
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• mice administered doxycycline at weaning develop spontaneous melanoma after an average of 15 weeks with a 50% penetrance
• withdrawal of doxycycline results in rapid, durable and complete tumor regression within 10 days
• doxycycline treated mice administered the MEK inhibitor Selumetinib or GSK1120212 show tumor stasis but not tumor regression
• doxycycline treated mice administered a selective inhibitor of CDK4/6, PD-0332991 together with either Selumetinib or GSK1120212 show tumor regression
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1Rdp mutation
(6 available);
any
Cdkn2a mutation
(62 available)
Tg(tetO-BRAF*V600E)29Lc mutation
(0 available)
Tg(Tyr-rtTA)37Lc mutation
(1 available)
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mortality/aging
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• 50% of doxycycline-treated mice die due to generally compromised physiological state secondary to renal failure despite frequent bladder irrigations
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neoplasm
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• at 24 weeks after doxycycline induction, mice develop prostate adenocarcinomas that exhibit epithelial-mesenchyme transition
• doxycycline-induced prostate adenomas can compress the bladder, originate from epithelial cells and express luminal, intermediate and basal cell markers
• doxycycline-treated mice that are subsequently castrated exhibit reduced prostate tumor proliferation compared to pre-castration
• withdrawal of doxycycline does not affect tumor cell proliferation
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endocrine/exocrine glands
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• at 16 weeks after doxycycline induction, prostates exhibit basaloid hyperplasia driven by urogenital epithelium unlike in wild-type mice
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• at 24 weeks after doxycycline induction, mice develop prostate adenocarcinomas that exhibit epithelial-mesenchyme transition
• doxycycline-induced prostate adenomas can compress the bladder, originate from epithelial cells and express luminal, intermediate and basal cell markers
• doxycycline-treated mice that are subsequently castrated exhibit reduced prostate tumor proliferation compared to pre-castration
• withdrawal of doxycycline does not affect tumor cell proliferation
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• at 5 weeks after doxycycline induction, prostates exhibit a moderate degree of aberrant proliferation unlike in wild-type mice
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reproductive system
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• at 16 weeks after doxycycline induction, prostates exhibit basaloid hyperplasia driven by urogenital epithelium unlike in wild-type mice
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• at 24 weeks after doxycycline induction, mice develop prostate adenocarcinomas that exhibit epithelial-mesenchyme transition
• doxycycline-induced prostate adenomas can compress the bladder, originate from epithelial cells and express luminal, intermediate and basal cell markers
• doxycycline-treated mice that are subsequently castrated exhibit reduced prostate tumor proliferation compared to pre-castration
• withdrawal of doxycycline does not affect tumor cell proliferation
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• at 5 weeks after doxycycline induction, prostates exhibit a moderate degree of aberrant proliferation unlike in wild-type mice
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pigmentation
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• upon induction of Ppargc1a expression in melanocytes, mice exhibit a noticeably darkened coat color relative to the yellow coat color of Ay/a Tg(Tyr-rtTA)37Lc/0 mice; however, the coat color does not become completely black
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• upon induction of Ppargc1a expression in melanocytes, mice exhibit significantly increased presence of melanin in hair follicles relative to Ay/a Tg(Tyr-rtTA)37Lc/0 mice
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integument
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• upon induction of Ppargc1a expression in melanocytes, mice exhibit a noticeably darkened coat color relative to the yellow coat color of Ay/a Tg(Tyr-rtTA)37Lc/0 mice; however, the coat color does not become completely black
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• upon induction of Ppargc1a expression in melanocytes, mice exhibit significantly increased presence of melanin in hair follicles relative to Ay/a Tg(Tyr-rtTA)37Lc/0 mice
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Analysis Tools