Phenotypes associated with this allele
mortality/aging
|
• less than Mendelian ratios of mice are recovered at 2 weeks after birth
|
limbs/digits/tail
|
• 100% of mice have polydactyly restricted to digits I or II of either the hindlimbs or forelimbs
• Background Sensitivity: on the 129S4/SvJaeSor background defects are restricted to only the last phalange
|
mortality/aging
|
• less than Mendelian ratios of mice are recovered at 2 weeks after birth
• Background Sensitivity: postnatal lethality is more severe in a 129S4/SvJaeSor background than in a mixed 129S4/SvJaeSor C57BL/6 background
|
mortality/aging
|
• less than Mendelian ratios of mice are recovered at 2 weeks after birth
|
mortality/aging
|
• less than Mendelian ratios of mice are recovered at 2 weeks after birth
• Background Sensitivity: postnatal lethality is more severe in a 129S4/SvJaeSor background than in a mixed 129S4/SvJaeSor C57BL/6 background
|
mortality/aging
|
• less than Mendelian ratios of mice are recovered at 2 weeks after birth
|
limbs/digits/tail
|
• 100% of mice have polydactyly restricted to digits I or II of either the hindlimbs or forelimbs
|
skeleton
|
• the perichondrium around forming digits is poorly organized
|
craniofacial
|
• at E14.5, palatal shelves fail to elevate
|
hearing/vestibular/ear
digestive/alimentary system
|
• at E14.5, palatal shelves fail to elevate
|
growth/size/body
|
• at E14.5, palatal shelves fail to elevate
|