Phenotypes associated with this allele

• Allele Symbol: Tlr9^M1Btlr
• Allele Name: mutation 1, Bruce Beutler
• Allele ID: MGI:3038816
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tlr9^M1Btlr/Tlr9^M1Btlr	involves: C57BL/6	MGI:3039438

Genotype
MGI:3039438

hm1

• Allelic Composition: Tlr9^M1Btlr/Tlr9^M1Btlr
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal NK cell physiology ( J:88906 )

• NK cell activation is significantly lower compared to C57BL/6 wild-type controls during mouse cytomegalovirus infection

abnormal NK T cell physiology ( J:88906 )

• NK-T cell activation is significantly lower compared to C57BL/6 wild-type controls during mouse cytomegalovirus infection

abnormal macrophage physiology ( J:88906 )

• macrophages are hyporesponsive to stimulation with unmethylated CpG-oligodeoxynucleotide (ODN)

• galactosamine sensitized mutants are protected from CpG-ODN induced mortality

abnormal cytokine secretion ( J:88906 )

• type 1 IFN, IFNgamma and IL-12 p40 levels are decreased compared to C57BL/6 wild-type controls following sublethal viral infection

increased susceptibility to Herpesvirales infection ( J:88906 )

• viral loads and mortality are significantly higher after mouse cytomegalovirus infection compared to C57BL/6 wild-type controls

increased susceptibility to Herpesvirales infection induced morbidity/mortality ( J:88906 )

• mortality is significantly higher after mouse cytomegalovirus infection compared to C57BL/6 wild-type controls

mortality/aging

increased susceptibility to Herpesvirales infection induced morbidity/mortality ( J:88906 )

• mortality is significantly higher after mouse cytomegalovirus infection compared to C57BL/6 wild-type controls

hematopoietic system

abnormal NK cell physiology ( J:88906 )

• NK cell activation is significantly lower compared to C57BL/6 wild-type controls during mouse cytomegalovirus infection

abnormal NK T cell physiology ( J:88906 )

• NK-T cell activation is significantly lower compared to C57BL/6 wild-type controls during mouse cytomegalovirus infection

abnormal macrophage physiology ( J:88906 )

• macrophages are hyporesponsive to stimulation with unmethylated CpG-oligodeoxynucleotide (ODN)

• galactosamine sensitized mutants are protected from CpG-ODN induced mortality