Phenotypes associated with this allele

• Allele Symbol: Il7r^tm1Iku
• Allele Name: targeted mutation 1, Koichi Ikuta
• Allele ID: MGI:3038693
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il7r^tm1Iku/Il7r^tm1Iku	involves: 129P2/OlaHsd * C57BL/6J	MGI:3038733

Genotype
MGI:3038733

hm1

• Allelic Composition: Il7r^tm1Iku/Il7r^tm1Iku
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:34658 )

N • normal natural killer (NK) cell development and function relative to wild-type mice

small thymus ( J:34658 )

thymus hypoplasia ( J:34658 )

• 20- to 70-fold reduction in thymus cellularity relative to wild-type mice

abnormal B cell differentiation ( J:34658 )

• severe impairment of B cell differentiation, with a 10-fold reduction in B220⁺IgM^- (pro-B to pre-B) cells relative to wild-type mice

• tendency of B-cell precursors to be blocked at the HSA^loBP-1^- fraction, indicating impaired B-cell development form fractions A to B

increased double-negative T cell number ( J:34658 )

• analysis of CD4^-CD8^- thymocytes with CD44 and CD25 markers indicates that the percentage of cells at the Cd44⁺CD25^- stage is increased relative to wild-type mice

abnormal gamma-delta T cell differentiation ( J:34658 )

• severe block in development of gamma-delta T cells in both thymic and extrathymic pathways

abnormal T cell subpopulation ratio ( J:34658 )

• slight increase in the ratio fo CD4⁺ to CD8⁺ T cells relative to wild-type mice

decreased leukocyte cell number ( J:34658 )

• slight reduction in the number of white blood cells in peripheral blood

decreased lymphocyte cell number ( J:34658 )

• 2-fold reduction in the number of lymphoid cells

decreased immature B cell number ( J:34658 )

• 40-fold decrease in percentage of B220⁺IgM⁺ (immature B cells) relative to wild-type mice

decreased mature B cell number ( J:34658 )

• 40-fold decrease in percentage of B220^highIgM⁺ (mature B cells) relative to wild-type mice

• 12- to 45-fold reduction n the number of mature IgM⁺B220⁺ B cells in spleen relative to wild-type mice

decreased B-1 B cell number ( J:34658 )

• reduction in the percentage of peritoneal B-1 (IgM⁺CD25⁺) cells relative to wild-type mice

decreased T cell number ( J:34658 )

• 5- to 33-fold reduction in the number of mature T cells bearing alpha-beta TCR in spleen relative to wild-type mice

decreased double-positive T cell number ( J:34658 )

• slight reduction in the percentage of CD4⁺CD8⁺ cells; however, thymocyte differentiation is not arrested

absent mature gamma-delta T cells ( J:34658 )

• absence of gamma-delta T cells from skin, gut, liver, and spleen

• in contrast, alpha beta T and B cells are still detectable in reduced numbers

spleen hypoplasia ( J:34658 )

• 3- to 12-fold reduction in spleen cellularity relative to wild-type mice

• 12- to 45-fold reduction n the number of mature IgM⁺B220⁺ B cells in spleen relative to wild-type mice

• 5- to 33-fold reduction in the number of mature T cells bearing alpha-beta TCR in spleen relative to wild-type mice

absent Peyer's patches ( J:45633 )

• anlages of Peyer's patches do not form

hematopoietic system

small thymus ( J:34658 )

thymus hypoplasia ( J:34658 )

• 20- to 70-fold reduction in thymus cellularity relative to wild-type mice

abnormal B cell differentiation ( J:34658 )

• severe impairment of B cell differentiation, with a 10-fold reduction in B220⁺IgM^- (pro-B to pre-B) cells relative to wild-type mice

• tendency of B-cell precursors to be blocked at the HSA^loBP-1^- fraction, indicating impaired B-cell development form fractions A to B

increased double-negative T cell number ( J:34658 )

• analysis of CD4^-CD8^- thymocytes with CD44 and CD25 markers indicates that the percentage of cells at the Cd44⁺CD25^- stage is increased relative to wild-type mice

abnormal gamma-delta T cell differentiation ( J:34658 )

• severe block in development of gamma-delta T cells in both thymic and extrathymic pathways

decreased bone marrow cell number ( J:34658 )

• slight reduction in bone marrow cellularity

abnormal T cell subpopulation ratio ( J:34658 )

• slight increase in the ratio fo CD4⁺ to CD8⁺ T cells relative to wild-type mice

decreased leukocyte cell number ( J:34658 )

• slight reduction in the number of white blood cells in peripheral blood

decreased lymphocyte cell number ( J:34658 )

• 2-fold reduction in the number of lymphoid cells

decreased immature B cell number ( J:34658 )

• 40-fold decrease in percentage of B220⁺IgM⁺ (immature B cells) relative to wild-type mice

decreased mature B cell number ( J:34658 )

• 40-fold decrease in percentage of B220^highIgM⁺ (mature B cells) relative to wild-type mice

• 12- to 45-fold reduction n the number of mature IgM⁺B220⁺ B cells in spleen relative to wild-type mice

decreased B-1 B cell number ( J:34658 )

• reduction in the percentage of peritoneal B-1 (IgM⁺CD25⁺) cells relative to wild-type mice

decreased T cell number ( J:34658 )

• 5- to 33-fold reduction in the number of mature T cells bearing alpha-beta TCR in spleen relative to wild-type mice

decreased double-positive T cell number ( J:34658 )

• slight reduction in the percentage of CD4⁺CD8⁺ cells; however, thymocyte differentiation is not arrested

absent mature gamma-delta T cells ( J:34658 )

• absence of gamma-delta T cells from skin, gut, liver, and spleen

• in contrast, alpha beta T and B cells are still detectable in reduced numbers

spleen hypoplasia ( J:34658 )

• 3- to 12-fold reduction in spleen cellularity relative to wild-type mice

• 12- to 45-fold reduction n the number of mature IgM⁺B220⁺ B cells in spleen relative to wild-type mice

• 5- to 33-fold reduction in the number of mature T cells bearing alpha-beta TCR in spleen relative to wild-type mice

endocrine/exocrine glands

small thymus ( J:34658 )

thymus hypoplasia ( J:34658 )

• 20- to 70-fold reduction in thymus cellularity relative to wild-type mice