Mouse Genome Informatics
hm1
    Gad2tm1Miya/Gad2tm1Miya
NOD.129P2-Gad2tm1Miya
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• between 16 and 32 weeks some mutants (7 out of 31) die suddenly from non-diabetic causes most likely related to seizures

behavior/neurological
• seizures induced by mild stimulation are seen in mutants

endocrine/exocrine glands
• no difference in the progression of insulitis (infiltration of the islet of Langerhans) is seen between mutants and wild-types by 12 weeks

growth/size
• after 4 weeks mild growth retardation is seen in mutants

homeostasis/metabolism
• no difference in incidence of diabetes is seen between female mutants and wild-types

immune system
• no difference in the progression of insulitis (infiltration of the islet of Langerhans) is seen between mutants and wild-types by 12 weeks

nervous system
• seizures induced by mild stimulation are seen in mutants

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:88785