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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Vsx1tm1Mci
targeted mutation 1, Roderick R McInnes
MGI:3033929
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Vsx1tm1Mci/Vsx1tm1Mci either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * Black Swiss) MGI:3033934
cx2
Irx6tm1Chow/Irx6tm1Chow
Vsx1tm1Mci/Vsx1tm1Mci
involves: 129S1/Sv * 129S1/SvImj * 129X1/SvJ MGI:5448239


Genotype
MGI:3033934
hm1
Allelic
Composition
Vsx1tm1Mci/Vsx1tm1Mci
Genetic
Background
either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * Black Swiss)
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
N
• no corneal defects were observed, either grossly or histologically (J:88182)
• no corneal defects were observed, either grossly or histologically (J:88182)
• incomplete terminal differentiation of OFF-cone bipolar cells in the retina as indicated by a reduction in expression of several markers (J:88182)
• incomplete terminal differentiation of OFF-cone bipolar cells in the retina as indicated by a reduction in expression of several markers (J:88182)
• reduced b-wave amplitude in response to white flashes (J:88182)
• putatively associated with incomplete differentiation and function of OFF cone bipolar cells (J:88182)
• reduced b-wave amplitude in response to white flashes (J:88182)
• putatively associated with incomplete differentiation and function of OFF cone bipolar cells (J:88182)

nervous system
• incomplete terminal differentiation of OFF-cone bipolar cells in the retina as indicated by a reduction in expression of several markers (J:88182)
• incomplete terminal differentiation of OFF-cone bipolar cells in the retina as indicated by a reduction in expression of several markers (J:88182)

behavior/neurological
N
• no overt behavioral or neurological phenotypes observed (J:88182)
• no overt behavioral or neurological phenotypes observed (J:88182)

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Keratoconus 1; KTCN1 148300 J:88182




Genotype
MGI:5448239
cx2
Allelic
Composition
Irx6tm1Chow/Irx6tm1Chow
Vsx1tm1Mci/Vsx1tm1Mci
Genetic
Background
involves: 129S1/Sv * 129S1/SvImj * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irx6tm1Chow mutation (0 available); any Irx6 mutation (4 available)
Vsx1tm1Mci mutation (0 available); any Vsx1 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• all Hcn4 expressing cells also express Tacr3, unlike in wild-type controls (J:189955)
• all Hcn4 expressing cells also express Tacr3, unlike in wild-type controls (J:189955)

nervous system
• all Hcn4 expressing cells also express Tacr3, unlike in wild-type controls (J:189955)
• all Hcn4 expressing cells also express Tacr3, unlike in wild-type controls (J:189955)





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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory