Mouse Genome Informatics
hm1
    Vsx1tm1Mci/Vsx1tm1Mci
either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * Black Swiss)
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
vision/eye
N
• no corneal defects were observed, either grossly or histologically (J:88182)
• incomplete terminal differentiation of OFF-cone bipolar cells in the retina as indicated by a reduction in expression of several markers
• reduced b-wave amplitude in response to white flashes
• putatively associated with incomplete differentiation and function of OFF cone bipolar cells

nervous system
• incomplete terminal differentiation of OFF-cone bipolar cells in the retina as indicated by a reduction in expression of several markers

behavior/neurological
N
• no overt behavioral or neurological phenotypes observed (J:88182)

Mouse Models of Human Disease
OMIM IDRef(s)
NOT Keratoconus 1; KTCN1 148300 J:88182


Mouse Genome Informatics
cx2
    Irx6tm1Chow/Irx6tm1Chow
Vsx1tm1Mci/Vsx1tm1Mci

involves: 129S1/Sv * 129S1/SvImj * 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
vision/eye
• all Hcn4 expressing cells also express Tacr3, unlike in wild-type controls

nervous system
• all Hcn4 expressing cells also express Tacr3, unlike in wild-type controls