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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Vsx1tm1Mci
targeted mutation 1, Roderick R McInnes
MGI:3033929
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Vsx1tm1Mci/Vsx1tm1Mci either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * Black Swiss) MGI:3033934
cx2
Irx6tm1Chow/Irx6tm1Chow
Vsx1tm1Mci/Vsx1tm1Mci
involves: 129S1/Sv * 129S1/SvImj * 129X1/SvJ MGI:5448239


Genotype
MGI:3033934
hm1
Allelic
Composition
Vsx1tm1Mci/Vsx1tm1Mci
Genetic
Background
either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * Black Swiss)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vsx1tm1Mci mutation (0 available); any Vsx1 mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
N
• no corneal defects were observed, either grossly or histologically
• incomplete terminal differentiation of OFF-cone bipolar cells in the retina as indicated by a reduction in expression of several markers
• reduced b-wave amplitude in response to white flashes
• putatively associated with incomplete differentiation and function of OFF cone bipolar cells

nervous system
• incomplete terminal differentiation of OFF-cone bipolar cells in the retina as indicated by a reduction in expression of several markers

behavior/neurological
N
• no overt behavioral or neurological phenotypes observed

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Keratoconus 1; KTCN1 148300 J:88182




Genotype
MGI:5448239
cx2
Allelic
Composition
Irx6tm1Chow/Irx6tm1Chow
Vsx1tm1Mci/Vsx1tm1Mci
Genetic
Background
involves: 129S1/Sv * 129S1/SvImj * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irx6tm1Chow mutation (0 available); any Irx6 mutation (11 available)
Vsx1tm1Mci mutation (0 available); any Vsx1 mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• all Hcn4 expressing cells also express Tacr3, unlike in wild-type controls

nervous system
• all Hcn4 expressing cells also express Tacr3, unlike in wild-type controls





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory