All Phenotypes Dph1<tm1Bhr> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dph1^tm1Bhr/Dph1^tm1Bhr	either: 129/Sv or (involves: 129/Sv * C57BL/6)	MGI:3033452
hm2	Dph1^tm1Bhr/Dph1^tm1Bhr	involves: 129S4/SvJae	MGI:5441715
ht3	Dph1^tm1Bhr/Dph1⁺	involves: 129/Sv * C57BL/6	MGI:3033453
ht4	Dph1^tm1Bhr/Dph1^tm2Bhr	involves: 129/Sv * C57BL/6	MGI:3033454
cx5	Dph1^tm1Bhr/Dph1^tm1Bhr Eef2^tm1.1Lepp/Eef2^tm1.1Lepp	involves: 129S4/SvJae * C57BL/6	MGI:5441716

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:88090 )

• homozygotes die soon after birth

embryonic lethality during organogenesis, incomplete penetrance ( J:88090 )

• 30-50% of embryos die between E11.5 and E13.5

embryonic lethality, complete penetrance ( J:88090 )

• Background Sensitivity: on a pure 129/Sv background, 100% of homozygous embryos die

cellular

abnormal cell cycle ( J:88090 )

• reduction in the number of S phase cells in cultured MEFs

craniofacial

abnormal craniofacial bone morphology ( J:88090 )

cleft palate ( J:88090 )

• seen in newborns

embryo

embryonic growth retardation ( J:88090 )

• development appears to be delayed 12-24 hours

abnormal neural tube morphology ( J:88090 )

• abnormalities of the neural tube in the midbrain area

growth/size/body

cleft palate ( J:88090 )

• seen in newborns

embryonic growth retardation ( J:88090 )

• development appears to be delayed 12-24 hours

decreased fetal weight ( J:88090 )

• body weight of E18.5 embryos is about 50% of normal

hematopoietic system

increased nucleated erythrocyte cell number ( J:88090 )

• erythrocytes remain nucleated at E16.5

homeostasis/metabolism

hydrops fetalis ( J:88090 )

• common by E13.5-E14.5

limbs/digits/tail

preaxial polydactyly ( J:88090 )

• preaxial polydactyly is common

respiratory system

abnormal lung development ( J:88090 )

• immature lung phenotype

• hypercellularity

thick lung-associated mesenchyme ( J:88090 )

• thickened mesenchyme

primary atelectasis ( J:88090 )

• lungs never inflate prior to death

respiratory failure ( J:88090 )

• homozygous mice die of respiratory distress

skeleton

abnormal craniofacial bone morphology ( J:88090 )

abnormal skeleton development ( J:88090 )

nervous system

abnormal neural tube morphology ( J:88090 )

• abnormalities of the neural tube in the midbrain area

digestive/alimentary system

cleft palate ( J:88090 )

• seen in newborns

Allelic Composition	Dph1^tm1Bhr/Dph1^tm1Bhr
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dph1^tm1Bhr mutation (0 available); any Dph1 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell physiology ( J:188600 )

• baseline protein synthesis rates in MEFs are decreased by 20% compared to control MEFs

• resistant to the decrease in protein synthesis rates induced by anthrax protective antigen + fusion protein 59 (PA + FP59)

• increase in the protein synthesis error rate due to -1 frameshifts in MEFs

decreased sensitivity to induced cell death ( J:188600 )

• MEFs are completely resistant to PA + FP59 induced cell death during 48 h toxin incubations

decreased fibroblast proliferation ( J:188600 )

Allelic Composition	Dph1^tm1Bhr/Dph1⁺
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dph1^tm1Bhr mutation (0 available); any Dph1 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor incidence ( J:88090 )

• 42% of heterozygotes develop tumors by 53-85 weeks of age

Allelic Composition	Dph1^tm1Bhr/Dph1^tm2Bhr
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dph1^tm1Bhr mutation (0 available); any Dph1 mutation (27 available)
Dph1^tm2Bhr mutation (0 available); any Dph1 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:88090 )

• homozygotes die soon after birth

embryonic lethality during organogenesis, incomplete penetrance ( J:88090 )

• 30-50% of embryos die between E11.5 and E13.5

embryo

embryonic growth retardation ( J:88090 )

• development appears to be delayed 12-24 hours

growth/size/body

embryonic growth retardation ( J:88090 )

• development appears to be delayed 12-24 hours

decreased fetal weight ( J:88090 )

• body weight at E18.5 is about 50% of normal

homeostasis/metabolism

hydrops fetalis ( J:88090 )

• common by E13.5-E14.5

Allelic Composition	Dph1^tm1Bhr/Dph1^tm1Bhr Eef2^tm1.1Lepp/Eef2^tm1.1Lepp
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dph1^tm1Bhr mutation (0 available); any Dph1 mutation (27 available)
Eef2^tm1.1Lepp mutation (0 available); any Eef2 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:188600 )

N	• many surviving adults are detected unlike in mice homozygous for Dph1^tm1Bhr alone

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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