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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Dnm1Ftfl
fitful
MGI:3033341
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Dnm1Ftfl/Dnm1Ftfl C57BL/6J-Dnm1Ftfl MGI:4822359
ht2
Dnm1Ftfl/Dnm1+ C57BL/6J-Dnm1Ftfl MGI:4822361
ht3
Dnm1Ftfl/Dnm1+ FVB.B6-Dnm1Ftfl/Frk MGI:5800570
ht4
Dnm1Ftfl/Dnm1tm1.2Frk involves: 129 * C57BL/6J * FVB MGI:5800565
ht5
Dnm1Ftfl/Dnm1tm2.2Frk involves: 129 * C57BL/6J * FVB MGI:5800569
ht6
Dnm1Ftfl/Dnm1tm1Pdc involves: C57BL/6J MGI:4822362
cx7
Dnm1Ftfl/Dnm1Ftfl
Tg(Pvalb-EGFP)B20Zjh/0
involves: C57BL/6 * C57BL/6J * FVB MGI:4822363


Genotype
MGI:4822359
hm1
Allelic
Composition
Dnm1Ftfl/Dnm1Ftfl
Genetic
Background
C57BL/6J-Dnm1Ftfl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnm1Ftfl mutation (2 available); any Dnm1 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• only survive into the second or third week of life

behavior/neurological
• post-natal day 12 (P12) progressive ataxia
• post-natal day 12 (P12) progressive ataxia characterized by an abnormal and uncoordinated stance and gait
• postnatal day 12 (P12) progressive ataxia characterized by an abnormal and uncoordinated stance and gait
• spontaneous convulsive seizures that usually result in death before weaning age
• seizures at P14-P16, a seizure episode typically lasts 30 seconds to one minute and is immediately followed by a clear diminishment in health and movement.

nervous system
• spontaneous convulsive seizures that usually result in death before weaning age
• seizures at P14-P16, a seizure episode typically lasts 30 seconds to one minute and is immediately followed by a clear diminishment in health and movement.
• Purkinje cell dendritic trees are markedly smaller in all homozygous mice examined at P17

hearing/vestibular/ear
• the latencies of most ABR peaks are progressively prolonged
• the amplitude of some of the ABR peaks are reduced in the mutants
• display a modest ABR threshold increase, approximately 15 dB, across all sound frequencies tested

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
idiopathic generalized epilepsy DOID:1827 OMIM:600669
J:163311




Genotype
MGI:4822361
ht2
Allelic
Composition
Dnm1Ftfl/Dnm1+
Genetic
Background
C57BL/6J-Dnm1Ftfl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnm1Ftfl mutation (2 available); any Dnm1 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• a modest reduction in seizure threshold to an acute electrical stimulus is observed
• the development of kindled seizures occurs more readily than wildtype mice in response to repeated electrical stimuli
• mice develop partial and generalized tonic-clonic seizures upon routine handling from approximately two to three months of age

nervous system
• a modest reduction in seizure threshold to an acute electrical stimulus is observed
• the development of kindled seizures occurs more readily than wildtype mice in response to repeated electrical stimuli
• mice develop partial and generalized tonic-clonic seizures upon routine handling from approximately two to three months of age




Genotype
MGI:5800570
ht3
Allelic
Composition
Dnm1Ftfl/Dnm1+
Genetic
Background
FVB.B6-Dnm1Ftfl/Frk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnm1Ftfl mutation (2 available); any Dnm1 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• non-maximal, non-lethal seizures

nervous system
• non-maximal, non-lethal seizures




Genotype
MGI:5800565
ht4
Allelic
Composition
Dnm1Ftfl/Dnm1tm1.2Frk
Genetic
Background
involves: 129 * C57BL/6J * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnm1Ftfl mutation (2 available); any Dnm1 mutation (22 available)
Dnm1tm1.2Frk mutation (0 available); any Dnm1 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• due to lethal seizures

nervous system
• lethal maximal seizures with earlier onset (6 to 7 weeks) and increased severity compared with with Dnm1Ftfl heterozygotes (11 to 12 weeks)
• reduced electroconvulsive threshold compared with Dnm1Ftfl heterozygotes
• abnormal interictal EEG patterns with episodes of epileptiform spikes

behavior/neurological
• lethal maximal seizures with earlier onset (6 to 7 weeks) and increased severity compared with with Dnm1Ftfl heterozygotes (11 to 12 weeks)
• reduced electroconvulsive threshold compared with Dnm1Ftfl heterozygotes

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
idiopathic generalized epilepsy DOID:1827 OMIM:600669
J:235711




Genotype
MGI:5800569
ht5
Allelic
Composition
Dnm1Ftfl/Dnm1tm2.2Frk
Genetic
Background
involves: 129 * C57BL/6J * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnm1Ftfl mutation (2 available); any Dnm1 mutation (22 available)
Dnm1tm2.2Frk mutation (0 available); any Dnm1 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• non-maximal, non-lethal seizures without interictal events similar to Dnm1Ftfl heterozygotes

behavior/neurological
• non-maximal, non-lethal seizures without interictal events similar to Dnm1Ftfl heterozygotes




Genotype
MGI:4822362
ht6
Allelic
Composition
Dnm1Ftfl/Dnm1tm1Pdc
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnm1Ftfl mutation (2 available); any Dnm1 mutation (22 available)
Dnm1tm1Pdc mutation (0 available); any Dnm1 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• slight tremor




Genotype
MGI:4822363
cx7
Allelic
Composition
Dnm1Ftfl/Dnm1Ftfl
Tg(Pvalb-EGFP)B20Zjh/0
Genetic
Background
involves: C57BL/6 * C57BL/6J * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnm1Ftfl mutation (2 available); any Dnm1 mutation (22 available)
Tg(Pvalb-EGFP)B20Zjh mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• Purkinje cell dendrites are polydendritic and the size of the dendritic arbor and degree of branching is reduced compared to wildtype





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory