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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
GckRgsc702
RIKEN Genomic Sciences Center (GSC), 702
MGI:3033227
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
GckRgsc702/GckRgsc702 involves: C57BL/6J * DBA/2J MGI:3038222
ht2
GckRgsc702/Gck+ involves: C57BL/6J * DBA/2J MGI:3038221


Genotype
MGI:3038222
hm1
Allelic
Composition
GckRgsc702/GckRgsc702
Genetic
Background
involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
GckRgsc702 mutation (1 available); any Gck mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygotes die within 1 week of birth

growth/size/body
• by P2 homozygotes are obviously growth retarded

homeostasis/metabolism
• hyperglycemia is apparent by P2
• blood glucose levels exceed 600 mg/dl by P4
• histological analysis reveals reduced liver glycogen levels
• at P1-2 marked glucosuria is seen

liver/biliary system
• the liver is markedly steatotic by P4
• histological analysis reveals enlarged fat droplets in hepatocytes

renal/urinary system
• at P1-2 marked glucosuria is seen

Mouse Models of Human Disease
OMIM ID Ref(s)
Maturity-Onset Diabetes of the Young, Type 2; MODY2 125851 J:88919




Genotype
MGI:3038221
ht2
Allelic
Composition
GckRgsc702/Gck+
Genetic
Background
involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
GckRgsc702 mutation (1 available); any Gck mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• increased glycosylated hemoglobin indicating a prolonged increase in serum glucose
• mutants have a free fed serum glucose level of 200 mg/dl or more, this was the basis for selection in the ENU screen
• mutants have impaired glucose responsive insulin secretion
• during an oral glucose tolerance test blood glucose levels are significantly higher

hematopoietic system
• increased glycosylated hemoglobin indicating a prolonged increase in serum glucose

Mouse Models of Human Disease
OMIM ID Ref(s)
Maturity-Onset Diabetes of the Young, Type 2; MODY2 125851 J:88919





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory