Mouse Genome Informatics
hm1
     GckRgsc702/GckRgsc702
involves: C57BL/6J * DBA/2J
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
mortality/aging
postnatal lethality ( J:88919 )
• homozygotes die within 1 week of birth

growth/size
decreased body weight ( J:88919 )
• by P2 homozygotes are obviously growth retarded

homeostasis/metabolism
hyperglycemia ( J:88919 )
• hyperglycemia is apparent by P2
• blood glucose levels exceed 600 mg/dl by P4
decreased glycogen level ( J:88919 )
• histological analysis reveals reduced liver glycogen levels
increased urine glucose level ( J:88919 )
• at P1-2 marked glucosuria is seen

liver/biliary system
hepatic steatosis ( J:88919 )
• the liver is markedly steatotic by P4
• histological analysis reveals enlarged fat droplets in hepatocytes

renal/urinary system
increased urine glucose level ( J:88919 )
• at P1-2 marked glucosuria is seen

Mouse Models of Human Disease
 OMIM IDRef(s)
Maturity-Onset Diabetes of the Young, Type 2; MODY2 125851 J:88919


Mouse Genome Informatics
ht2
     GckRgsc702/Gck+
involves: C57BL/6J * DBA/2J
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
homeostasis/metabolism
increased glycosylated hemoglobin level ( J:88919 )
• increased glycosylated hemoglobin indicating a prolonged increase in serum glucose
hyperglycemia ( J:88919 )
• mutants have a free fed serum glucose level of 200 mg/dl or more, this was the basis for selection in the ENU screen
decreased circulating insulin level ( J:88919 )
• mutants have impaired glucose responsive insulin secretion
impaired glucose tolerance ( J:88919 )
• during an oral glucose tolerance test blood glucose levels are significantly higher

hematopoietic system
increased glycosylated hemoglobin level ( J:88919 )
• increased glycosylated hemoglobin indicating a prolonged increase in serum glucose

Mouse Models of Human Disease
 OMIM IDRef(s)
Maturity-Onset Diabetes of the Young, Type 2; MODY2 125851 J:88919