mortality/aging
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• reduced survival due to massive lymphoproliferation and autoimmune disease
• greater than 50% died by 4 months
• 85% had died by 7 months
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endocrine/exocrine glands
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• lymphocytic infiltration
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hematopoietic system
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• more accelerated and pronounced than in homozygous Tnfsf6gld mice on a C57BL/6 genetic background
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• abnormal CD3+B220+CD4-CD8- T cells represented 70% to 87% of the cells that accumulated in the spleen and lymph nodes at 12 to 13 weeks of age
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• hypergammaglobulinemia
• significantly higher than those observed in wild-type controls and in homozygous Tnfsf6gld mice
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homeostasis/metabolism
immune system
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• more accelerated and pronounced than in homozygous Tnfsf6gld mice on a C57BL/6 genetic background
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• abnormal CD3+B220+CD4-CD8- T cells represented 70% to 87% of the cells that accumulated in the spleen and lymph nodes at 12 to 13 weeks of age
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• hypergammaglobulinemia
• significantly higher than those observed in wild-type controls and in homozygous Tnfsf6gld mice
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• lymphadenopathy associated with lymphocytic infiltration into multiple organs
• more accelerated and pronounced than in homozygous Tnfsf6gld mice on a C57BL/6 genetic background
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• lymphoproliferation of both normal B and T cells as well as abnormal double negative T cells in spleen and lymph nodes
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• observed in most mice with a mixed genetic background involving 129/Sv and C57BL/6 as well as in incipient congenic mice (backcrossed to C57BL/6 for 5 generations)
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liver/biliary system
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• associated with moderate to severe lymphocytic infiltration
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renal/urinary system
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• observed in most mice with a mixed genetic background involving 129/Sv and C57BL/6 as well as in incipient congenic mice (backcrossed to C57BL/6 for 5 generations)
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• observed in most mice with a mixed genetic background involving 129/Sv and C57BL/6 as well as in incipient congenic mice (backcrossed to C57BL/6 for 5 generations)
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digestive/alimentary system
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• lymphocytic infiltration
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growth/size/body
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• associated with moderate to severe lymphocytic infiltration
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• more accelerated and pronounced than in homozygous Tnfsf6gld mice on a C57BL/6 genetic background
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