Phenotypes associated with this allele

• Allele Symbol: Slc8a3^tm1Sso
• Allele Name: targeted mutation 1, Sophie Sokolow
• Allele ID: MGI:3028976
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc8a3^tm1Sso/Slc8a3^tm1Sso	Not Specified	MGI:3028980

Genotype
MGI:3028980

hm1

• Allelic Composition: Slc8a3^tm1Sso/Slc8a3^tm1Sso
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired coordination ( J:87615 )

• performed poorly in wire and rotarod tests

fatigue ( J:87615 )

• fatigue more readily

muscle

skeletal muscle fiber necrosis ( J:87615 )

• necrotic muscle fibers found in skeletal muscles, 10% of fibers or fewer

nervous system

increased cerebral infarct size ( J:131833 )

• the extent of the eschemia resulting from occlusion of the middle cerebral artery is greatly increased

neurodegeneration ( J:131833 )

• reduced neuron survival after oxygen glucose deprivation

abnormal synaptic transmission ( J:87615 )

• impaired neuromuscular transmission

abnormal channel response ( J:87615 )

homeostasis/metabolism

increased cerebral infarct size ( J:131833 )

• the extent of the eschemia resulting from occlusion of the middle cerebral artery is greatly increased

cellular

skeletal muscle fiber necrosis ( J:87615 )

• necrotic muscle fibers found in skeletal muscles, 10% of fibers or fewer