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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Anxa2tm1Kah
targeted mutation 1, Katherine A Hajjar
MGI:3028929
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Anxa2tm1Kah/Anxa2tm1Kah involves: 129X1/SvJ * C57BL/6 MGI:3028933


Genotype
MGI:3028933
hm1
Allelic
Composition
Anxa2tm1Kah/Anxa2tm1Kah
Genetic
Background
involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Anxa2tm1Kah mutation (2 available); any Anxa2 mutation (46 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• defects in fibrin and collagen I matrix remodeling
• neoangiogenesis is inhibited

growth/size/body
• weight was 10-13% below normal by 12 months

hematopoietic system

homeostasis/metabolism
• 1.5-2.9 fold increase in fibrin in lung, spleen, small intestine, liver, heart, and kidney by 2 months
• also microvascular accumulation of fibrin in these tissues
• very little plasmin generation from endothelial cell surfaces
• increased succeptibility to acute carotid artery thrombosis





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory