All Phenotypes Spo11<tm1Rdco> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Spo11^tm1Rdco/Spo11^tm1Rdco	involves: 129 * C57BL/6	MGI:3814450
hm2	Spo11^tm1Rdco/Spo11^tm1Rdco	involves: 129S6/SvEvTac	MGI:3027900
cx3	Mael^tm1Bort/Mael^tm1Bort Spo11^tm1Rdco/Spo11^tm1Rdco	involves: 129 * C57BL/6	MGI:3814451

Allelic Composition	Spo11^tm1Rdco/Spo11^tm1Rdco
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spo11^tm1Rdco mutation (0 available); any Spo11 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

arrest of male meiosis ( J:140402 )

• meiosis arrested at zygotene stage

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal reproductive system morphology ( J:65881 )

abnormal female reproductive system morphology ( J:65881 )

abnormal ovary morphology ( J:65881 )

• defects seen in fetal ovaries at E15

abnormal gametogenesis ( J:65881 )

abnormal female meiosis ( J:65881 )

• problems in early stages of meiosis I

abnormal spermatogenesis ( J:65881 )

abnormal male meiosis ( J:194067 )

• male germ cells lack double strand breaks and are defective recombination and synapsis

• preleptotene pairing is impaired

• transgene expression of Spo11alpha does not rescue preleptotene pairing

arrest of male meiosis ( J:65881 )

• meiosis in spermatocytes normal through leptotene stage

• meiosis arrested at zygotene stage

• little or no synapsis (about 5-10% of nuclei)

• synapsis that does occur is between nonhomologous chromosomes

• lack of Rad51 and Dmc1 foci

• no spermatocytes reach pachytene stage

abnormal male reproductive system morphology ( J:65881 )

abnormal seminiferous tubule morphology ( J:65881 )

• many tubules are barren

• about 20% of tubules with clusters of apoptotic cells

small testis ( J:65881 )

abnormal fertility/fecundity ( J:65881 )

female infertility ( J:65881 )

male infertility ( J:65881 )

endocrine/exocrine glands

abnormal ovary morphology ( J:65881 )

• defects seen in fetal ovaries at E15

abnormal seminiferous tubule morphology ( J:65881 )

• many tubules are barren

• about 20% of tubules with clusters of apoptotic cells

small testis ( J:65881 )

Allelic Composition	Mael^tm1Bort/Mael^tm1Bort Spo11^tm1Rdco/Spo11^tm1Rdco
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mael^tm1Bort mutation (0 available); any Mael mutation (24 available)
Spo11^tm1Rdco mutation (0 available); any Spo11 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal male meiosis ( J:140402 )

• large numbers of double stranded DNA breaks occur in spermatocytes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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