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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Hc0
deficient
MGI:3027637
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Hc0/Hc0 B10.D2-Hc0 MGI:3714384
hm2
Hc0/Hc0 B10.D2-Hc0 H2d H2-T18c/oSnJ MGI:3806150
hm3
Hc0/Hc0 involves: A/J * C3H/HeJ MGI:3623810
hm4
Hc0/Hc0 involves: C57BL/10SnJ MGI:3663127
cx5
Hc0/Hc0
Tg(TcrbBL17)1Lmor/0
involves: DBA/1J * SWR/J MGI:3790651


Genotype
MGI:3714384
hm1
Allelic
Composition
Hc0/Hc0
Genetic
Background
B10.D2-Hc0
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hc0 mutation (27 available); any Hc mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• mice are resistant to ischemia reperfusion-induced renal injury
• serum urea nitrogen is reduced 35% to 40% compared to wild-type mice subjected to ischemia reperfusion

liver/biliary system
• resistance to hepatic fibrosis
• less advanced stages of liver fibrosis
• reduced hepatic collagen concentrations




Genotype
MGI:3806150
hm2
Allelic
Composition
Hc0/Hc0
Genetic
Background
B10.D2-Hc0 H2d H2-T18c/oSnJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hc0 mutation (27 available); any Hc mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
N
• mice exhibit normal ethanol-induced liver steatosis
• following exposure to ethanol, mice do not exhibit an increase in alanine aminotransferase, TNF-alpha, IL6 and IFN-gamma as in similarly treated wild-type mice




Genotype
MGI:3623810
hm3
Allelic
Composition
Hc0/Hc0
Genetic
Background
involves: A/J * C3H/HeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hc0 mutation (27 available); any Hc mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• susceptibility to allergen-induced bronchial hyperresponsiveness




Genotype
MGI:3663127
hm4
Allelic
Composition
Hc0/Hc0
Genetic
Background
involves: C57BL/10SnJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hc0 mutation (27 available); any Hc mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• Hc-deficient mice display a 25-fold reduction in bacterial clearance after 1 and 3 hours after CLP compared to control mice




Genotype
MGI:3790651
cx5
Allelic
Composition
Hc0/Hc0
Tg(TcrbBL17)1Lmor/0
Genetic
Background
involves: DBA/1J * SWR/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hc0 mutation (27 available); any Hc mutation (38 available)
Tg(TcrbBL17)1Lmor mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• resistance to collagen-induced arthritis

skeleton
• resistance to collagen-induced arthritis





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory