All Phenotypes Mre11a<tm1Jpt> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mre11a^tm1Jpt
targeted mutation 1, John H J Petrini
MGI:3027036

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mre11a^tm1Jpt/Mre11a^tm1Jpt	involves: 129S7/SvEvBrd	MGI:3831180
hm2	Mre11a^tm1Jpt/Mre11a^tm1Jpt	involves: 129S7/SvEvBrd * C57BL/6	MGI:3027041
cn3	Lig4^tm1Pmc/Lig4^tm1Pmc Mre11a^tm1Jpt/Mre11a^tm1Jpt Tg(Nes-cre)1Kln/0	involves: 129S1/SvImJ * 129S7/SvEvBrd * C57BL/6 * SJL	MGI:3831179
cx4	Lig4^tm1Icrf/Lig4^tm1Icrf Mre11a^tm1Jpt/Mre11a^tm1Jpt	involves: 129 * 129S7/SvEvBrd	MGI:3831181
cx5	Mre11a^tm1Jpt/Mre11a^tm1Jpt Rad50^tm2Jpt/Rad50^tm2Jpt	involves: 129S7/SvEvBrd * C57BL/6	MGI:3615671
cx6	Mre11a^tm1Jpt/Mre11a⁺ Rad50^tm2Jpt/Rad50^tm2Jpt	involves: 129S7/SvEvBrd * C57BL/6	MGI:3615680

Allelic Composition	Mre11a^tm1Jpt/Mre11a^tm1Jpt
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mre11a^tm1Jpt mutation (1 available); any Mre11a mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

decreased cellular sensitivity to ionizing radiation ( J:144172 )

• at E13.5, E15.5, and P5, mice exhibit resistance to ionizing radiation-induced apoptosis in the retina and dentate gyrus compared to wild-type mice

• ionizing radiation-induced apoptosis in the thymus is reduced compared to in wild-type mice

• however, ionizing radiation-induced apoptosis in the proliferating embryonic ventricular zone is normal

Allelic Composition	Mre11a^tm1Jpt/Mre11a^tm1Jpt
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mre11a^tm1Jpt mutation (1 available); any Mre11a mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell cycle checkpoint function ( J:87088 , J:103922 )

• checkpoint defects; MEFs fail to arrest or suffer attrition either in S phase or at the G2/M border (J:87088)

• MEFs exhibit defects in G1/S, intra-S-phase, and G2/M checkpoints after ionizing radiation induced DNA damage (J:103922)

increased cellular sensitivity to ionizing radiation ( J:87088 , J:103922 )

• mouse embryonic fibroblasts (MEFs) are sensitive to ionizing radiation (J:87088)

• MEFs exhibit increased sensitivity to ionizing radiation (J:103922)

chromosomal instability ( J:87088 )

• passage 7 MEFs show chromosomal instability; 43% vs. 19% of wild-type metaphases contain at least 1 aberration and the number of aberrations per metaphase is increased

• 33% of early passage MEFs (p3) and 65% of late passage (greater than 5) MEFs show aberrant metaphases

• translocasions and fusions are seen in 5 of 32 early and 7 of 27 late passage MEFs

• 18% of metaphases in splenocyte cultures exhibit aberrations

chromosome breakage ( J:103922 )

induced chromosome breakage ( J:87088 )

• MEFs are hypersensitive to irradiation-induced chromosome breakage

maternal effect ( J:87088 )

• embryonic viability is drastically reduced in homozygous mothers but not in heterozygous intercrosses, indicating a maternal effect on viability

reproductive system

reduced female fertility ( J:87088 )

neoplasm

neoplasm ( J:87088 )

N	• inspite of cell cycle checkpoint failure and chromosomal instability, mice are not prone to malignancy including lymphomagenesis

Allelic Composition	Lig4^tm1Pmc/Lig4^tm1Pmc Mre11a^tm1Jpt/Mre11a^tm1Jpt Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129S1/SvImJ * 129S7/SvEvBrd * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lig4^tm1Pmc mutation (0 available); any Lig4 mutation (44 available)
Mre11a^tm1Jpt mutation (1 available); any Mre11a mutation (48 available)
Tg(Nes-cre)1Kln mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

ataxia ( J:144172 )

• at 7 to 9 months, mice develop severe hind-limb ataxia or unknown etiology

nervous system

nervous system phenotype ( J:144172 )

N	• unlike in mice with Lig4^tm1Pmc/Lig4^tm1Pmc Tg(Nes-cre)1Kln, mice do not exhibit any increased apoptosis in the nervous system, and microencephaly is rescued

Allelic Composition	Lig4^tm1Icrf/Lig4^tm1Icrf Mre11a^tm1Jpt/Mre11a^tm1Jpt
Genetic Background	involves: 129 * 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lig4^tm1Icrf mutation (0 available); any Lig4 mutation (44 available)
Mre11a^tm1Jpt mutation (1 available); any Mre11a mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:144172 )

• survived to birth but died thereafter

cellular

decreased cellular sensitivity to ionizing radiation ( J:144172 )

• ionizing radiation-induced apoptosis in the developing nervous system is almost completely blocked

• mice exhibit reduced ionizing radiation-induced apoptosis in the telencephalon, metencephalon, spinal cord, and dorsal root ganglia compared to in wild-type mice

Allelic Composition	Mre11a^tm1Jpt/Mre11a^tm1Jpt Rad50^tm2Jpt/Rad50^tm2Jpt
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mre11a^tm1Jpt mutation (1 available); any Mre11a mutation (48 available)
Rad50^tm2Jpt mutation (0 available); any Rad50 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:103922 )

• although some die prematurely, survival time is increased compared to homozygous Rad50^tm2Jpt mice, with 24 of 29 alive at 5 months of age with no signs of anemia

neoplasm

increased lymphoma incidence ( J:103922 )

• 4 of 24 develop lymphoma

cellular

abnormal cell cycle checkpoint function ( J:103922 )

• MEFs exhibit defects in G1/S, intra-S-phase, and G2/M checkpoints after ionizing radiation induced DNA damage

increased cellular sensitivity to ionizing radiation ( J:103922 )

• MEFs exhibit increased sensitivity to ionizing radiation

chromosome breakage ( J:103922 )

hematopoietic system

hematopoietic system phenotype ( J:103922 )

N	• do not observe hematopoietic cell attrition as in homozygous Rad50 mice, indicating rescue of hematopoietic defects

Allelic Composition	Mre11a^tm1Jpt/Mre11a⁺ Rad50^tm2Jpt/Rad50^tm2Jpt
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:103922 )

• 32 of 49 die before 5 months of age, however survival time is increased compared to homozygous Rad50^tm2Jpt mice, as 17 mutants survive past 5 months of age

hematopoietic system

abnormal hematopoietic system morphology/development ( J:103922 )

• 19 of the 32 mutants that die exhibited hematopoietic attrition

anemia ( J:103922 )

• 19 of the 32 mutants that die exhibit anemia

neoplasm

increased lymphoma incidence ( J:103922 )

• 10 of the 32 mutants that die succumb to lymphoma

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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