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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Epha4tm5Kln
targeted mutation 5, Rudiger Klein
MGI:3026688
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Epha4tm5Kln/Epha4tm5Kln involves: 129 * C57BL/6 MGI:3026788
hm2
 		Epha4tm5Kln/Epha4tm5Kln involves: 129S/SvEv * C57BL/6 MGI:3608665
hm3
 		Epha4tm5Kln/Epha4tm5Kln involves: 129/Sv * C57BL/6 MGI:3694671
ht4
 		Epha4tm5Kln/Epha4+ involves: 129/Sv * C57BL/6 MGI:3694678


Genotype
MGI:3026788
hm1
Allelic
Composition		 Epha4tm5Kln/Epha4tm5Kln
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epha4tm5Kln mutation (0 available); any Epha4 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal gait ( J:87398 )
• hopping gait characterized by mirrored limb movement

nervous system
nervous system phenotype ( J:87398 )
N
• normal hippocampal architecture
• normal long term plasticity at CA3-CA1 synapses indicated by normal LTP and LTD
abnormal corticospinal tract morphology ( J:87398 )
• exhibition of mirrored limb movement indicates axons aberrantly crossed the midline boundary of the spinal cord




Genotype
MGI:3608665
hm2
Allelic
Composition		 Epha4tm5Kln/Epha4tm5Kln
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epha4tm5Kln mutation (0 available); any Epha4 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal gait ( J:101019 )
• hopping gait

nervous system
ectopic thalamus ( J:101019 )
• in 83% of homozygotes thalamic neurons are located more medially than in wild-type mice




Genotype
MGI:3694671
hm3
Allelic
Composition		 Epha4tm5Kln/Epha4tm5Kln
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epha4tm5Kln mutation (0 available); any Epha4 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal barrel cortex morphology ( J:115279 )
• 83% of mice display abnormal thalamocortical (TC) projections from the ventro-posterior-medial (VPM) part of the ventro-basal nucleus (VB) to the primary somatosensory area S1, with cells located at ectopic positions with respect to the position corresponding to normal barreloid clusters
abnormal innervation ( J:115279 )
• 83% of mice display abnormal thalamocortical (TC) projections from the ventro-posterior-medial (VPM) part of the ventro-basal nucleus (VB) to the primary somatosensory area S1, with cells located at ectopic positions with respect to the position corresponding to normal barreloid clusters




Genotype
MGI:3694678
ht4
Allelic
Composition		 Epha4tm5Kln/Epha4+
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epha4tm5Kln mutation (0 available); any Epha4 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal barrel cortex morphology ( J:115279 )
• 50% of heterozygotes show similar abnormalities in TC to homozygotes
abnormal innervation ( J:115279 )
• 50% of heterozygotes show similar abnormalities in TC to homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory