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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cdkn2atm4Rdp
targeted mutation 4, Ronald DePinho
MGI:2687203
Summary 17 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Cdkn2atm4Rdp/Cdkn2a+
Krastm4Tyj/Kras+
Smad4tm1Rdp/Smad4tm1Rdp
Ptf1atm1.1(cre)Cvw/Ptf1a+
involves: 129 * FVB/N MGI:3695424
cn2
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Krastm4Tyj/Kras+
Smad4tm1Rdp/Smad4tm1Rdp
Ptf1atm1.1(cre)Cvw/Ptf1a+
involves: 129 * FVB/N MGI:3695428
cn3
Braftm1Mmcm/Braf+
Cdkn2atm4Rdp/Cdkn2atm4Rdp
involves: 129P2/OlaHsd MGI:3712026
cn4
Cdkn2atm4Rdp/Cdkn2a+
Krastm4Tyj/Kras+
Smad4tm1Rdp/Smad4tm1Rdp
Tg(Pdx1-cre)89.1Dam/0
involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA * FVB/N MGI:3695426
cn5
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Krastm4Tyj/Kras+
Smad4tm1Rdp/Smad4tm1Rdp
Tg(Pdx1-cre)89.1Dam/0
involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA * FVB/N MGI:3695429
cn6
Cdkn2atm4Rdp/Cdkn2a+
Smad4tm1Rdp/Smad4tm1Rdp
Tg(Pdx1-cre)89.1Dam/0
involves: 129S/SvEv * C57BL/6 * CBA * FVB/N MGI:3695427
cn7
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Krastm4Tyj/Kras+
Ptf1atm1.1(cre)Cvw/Ptf1a+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ MGI:3695431
cn8
Cdkn2atm4Rdp/Cdkn2a+
Krastm4Tyj/Kras+
Ptf1atm1.1(cre)Cvw/Ptf1a+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ MGI:3695432
cn9
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Myf6tm1(cre)Mrc/Myf6+
Pax3tm1Mrc/Pax3tm1Mrc
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:3844659
cn10
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Krastm4Tyj/Kras+
involves: 129S4/SvJae MGI:5491219
cn11
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Krastm4Tyj/Kras+
involves: 129S4/SvJae * C57BL/6 MGI:5559056
cn12
Cdkn2atm4Rdp/Cdkn2a+
Krastm4Tyj/Kras+
Tg(Pdx1-cre)89.1Dam/0
involves: 129S4/SvJae * C57BL/6 * CBA MGI:3695430
cn13
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Krastm4Tyj/Kras+
Tg(Pdx1-cre)89.1Dam/0
involves: 129S4/SvJae * C57BL/6 * CBA MGI:5441554
cn14
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Krastm4Tyj/Kras+
Tg(Pdx1-cre)89.1Dam/0
involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N MGI:2687217
cn15
Cdkn2atm4Rdp/Cdkn2a+
Krastm4Tyj/Kras+
Tg(Pdx1-cre)89.1Dam/0
involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N MGI:5308806
cn16
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Krastm4Tyj/Krastm4Tyj
Tg(Pdx1-cre)89.1Dam/0
involves: 129S4/SvJae * C57BL/6 * DBA/2 MGI:4355874
cn17
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Tg(Pdx1-cre)89.1Dam/0
involves: C57BL/6 * CBA * FVB/N MGI:2687205


Genotype
MGI:3695424
cn1
Allelic
Composition
Cdkn2atm4Rdp/Cdkn2a+
Krastm4Tyj/Kras+
Smad4tm1Rdp/Smad4tm1Rdp
Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic
Background
involves: 129 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm4Rdp mutation (0 available); any Cdkn2a mutation (26 available)
Krastm4Tyj mutation (4 available); any Kras mutation (30 available)
Ptf1atm1.1(cre)Cvw mutation (1 available); any Ptf1a mutation (6 available)
Smad4tm1Rdp mutation (0 available); any Smad4 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• average tumor-free survival is 14 weeks (J:116130)
• average tumor-free survival is 14 weeks (J:116130)

tumorigenesis
• 5 of 13 mice develop intraductal papillary mucinous neoplasms (J:116130)
• tumor fibrosis is increased compared to mice wild-type for Smad4 (J:116130)
• 5 of 13 mice develop intraductal papillary mucinous neoplasms (J:116130)
• tumor fibrosis is increased compared to mice wild-type for Smad4 (J:116130)
• 12 of 13 mice develop pancreatic ductal adenocarcinoma (J:116130)
• the proportion of undifferentiated carcinomas is decreased compared to mice wild-type for Smad4 (J:116130)
• 12 of 13 mice develop pancreatic ductal adenocarcinoma (J:116130)
• the proportion of undifferentiated carcinomas is decreased compared to mice wild-type for Smad4 (J:116130)




Genotype
MGI:3695428
cn2
Allelic
Composition
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Krastm4Tyj/Kras+
Smad4tm1Rdp/Smad4tm1Rdp
Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic
Background
involves: 129 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm4Rdp mutation (0 available); any Cdkn2a mutation (26 available)
Krastm4Tyj mutation (4 available); any Kras mutation (30 available)
Ptf1atm1.1(cre)Cvw mutation (1 available); any Ptf1a mutation (6 available)
Smad4tm1Rdp mutation (0 available); any Smad4 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• average tumor-free survival is 8.8 weeks (J:116130)
• average tumor-free survival is 8.8 weeks (J:116130)

tumorigenesis
• 4 of 4 mice develop pancreatic ductal adenocarcinoma (J:116130)
• the proportion of undifferentiated carcinomas is decreased compared to mice wild-type for Smad4 (J:116130)
• tumor fibrosis is increased compared to mice wild-type for Smad4 (J:116130)
• 4 of 4 mice develop pancreatic ductal adenocarcinoma (J:116130)
• the proportion of undifferentiated carcinomas is decreased compared to mice wild-type for Smad4 (J:116130)
• tumor fibrosis is increased compared to mice wild-type for Smad4 (J:116130)




Genotype
MGI:3712026
cn3
Allelic
Composition
Braftm1Mmcm/Braf+
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braftm1Mmcm mutation (2 available); any Braf mutation (20 available)
Cdkn2atm4Rdp mutation (0 available); any Cdkn2a mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
tumorigenesis
• Cre-treated mice show scattered papillary adenomas with evidence of subpleural nodules harboring cords of atypical cells trapped within regions of mesenchymal proliferation (J:121715)
• 2/4 mice display multiple lung tumors with a bronchioalveolar component (J:121715)
• Cre-treated mice show scattered papillary adenomas with evidence of subpleural nodules harboring cords of atypical cells trapped within regions of mesenchymal proliferation (J:121715)
• 2/4 mice display multiple lung tumors with a bronchioalveolar component (J:121715)




Genotype
MGI:3695426
cn4
Allelic
Composition
Cdkn2atm4Rdp/Cdkn2a+
Krastm4Tyj/Kras+
Smad4tm1Rdp/Smad4tm1Rdp
Tg(Pdx1-cre)89.1Dam/0
Genetic
Background
involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm4Rdp mutation (0 available); any Cdkn2a mutation (26 available)
Krastm4Tyj mutation (4 available); any Kras mutation (30 available)
Smad4tm1Rdp mutation (0 available); any Smad4 mutation (12 available)
Tg(Pdx1-cre)89.1Dam mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• average tumor-free survival is 12.6 weeks (J:116130)
• average tumor-free survival is 12.6 weeks (J:116130)

tumorigenesis
• 4 of 12 mice develop intraductal papillary mucinous neoplasms (J:116130)
• tumor fibrosis is increased compared to mice wild-type for Smad4 (J:116130)
• 4 of 12 mice develop intraductal papillary mucinous neoplasms (J:116130)
• tumor fibrosis is increased compared to mice wild-type for Smad4 (J:116130)
• 4 of 12 mice develop pancreatic ductal adenocarcinoma (J:116130)
• the proportion of undifferentiated carcinomas is decreased compared to mice wild-type for Smad4 (J:116130)
• 4 of 12 mice develop pancreatic ductal adenocarcinoma (J:116130)
• the proportion of undifferentiated carcinomas is decreased compared to mice wild-type for Smad4 (J:116130)
• 8 of 12 mice develop gastric cancer (J:116130)
• 8 of 12 mice develop gastric cancer (J:116130)




Genotype
MGI:3695429
cn5
Allelic
Composition
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Krastm4Tyj/Kras+
Smad4tm1Rdp/Smad4tm1Rdp
Tg(Pdx1-cre)89.1Dam/0
Genetic
Background
involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm4Rdp mutation (0 available); any Cdkn2a mutation (26 available)
Krastm4Tyj mutation (4 available); any Kras mutation (30 available)
Smad4tm1Rdp mutation (0 available); any Smad4 mutation (12 available)
Tg(Pdx1-cre)89.1Dam mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• average tumor-free survival is 7.4 weeks (J:116130)
• average tumor-free survival is 7.4 weeks (J:116130)

tumorigenesis
• 3 of 10 mice develop intraductal papillary mucinous neoplasms (J:116130)
• tumor fibrosis is increased compared to mice wild-type for Smad4 (J:116130)
• 3 of 10 mice develop intraductal papillary mucinous neoplasms (J:116130)
• tumor fibrosis is increased compared to mice wild-type for Smad4 (J:116130)
• 9 of 10 mice develop pancreatic ductal adenocarcinoma (J:116130)
• the proportion of undifferentiated carcinomas is decreased compared to mice wild-type for Smad4 (J:116130)
• 9 of 10 mice develop pancreatic ductal adenocarcinoma (J:116130)
• the proportion of undifferentiated carcinomas is decreased compared to mice wild-type for Smad4 (J:116130)
• 5 of 10 mice develop gastric cancer (J:116130)
• 5 of 10 mice develop gastric cancer (J:116130)




Genotype
MGI:3695427
cn6
Allelic
Composition
Cdkn2atm4Rdp/Cdkn2a+
Smad4tm1Rdp/Smad4tm1Rdp
Tg(Pdx1-cre)89.1Dam/0
Genetic
Background
involves: 129S/SvEv * C57BL/6 * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm4Rdp mutation (0 available); any Cdkn2a mutation (26 available)
Smad4tm1Rdp mutation (0 available); any Smad4 mutation (12 available)
Tg(Pdx1-cre)89.1Dam mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
tumorigenesis
N
• tumor-free survival is greater than 52 weeks and only 1 of 10 mice developed an intraductal papillary mucinous neoplasm (J:116130)
• tumor-free survival is greater than 52 weeks and only 1 of 10 mice developed an intraductal papillary mucinous neoplasm (J:116130)




Genotype
MGI:3695431
cn7
Allelic
Composition
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Krastm4Tyj/Kras+
Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm4Rdp mutation (0 available); any Cdkn2a mutation (26 available)
Krastm4Tyj mutation (4 available); any Kras mutation (30 available)
Ptf1atm1.1(cre)Cvw mutation (1 available); any Ptf1a mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• average tumor-free survival is 8.6 weeks (J:116130)
• average tumor-free survival is 8.6 weeks (J:116130)

tumorigenesis
• 6 of 6 mice develop pancreatic ductal adenocarcinoma (J:116130)
• 6 of 6 mice develop pancreatic ductal adenocarcinoma (J:116130)




Genotype
MGI:3695432
cn8
Allelic
Composition
Cdkn2atm4Rdp/Cdkn2a+
Krastm4Tyj/Kras+
Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm4Rdp mutation (0 available); any Cdkn2a mutation (26 available)
Krastm4Tyj mutation (4 available); any Kras mutation (30 available)
Ptf1atm1.1(cre)Cvw mutation (1 available); any Ptf1a mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• average tumor-free survival is 38 weeks (J:116130)
• average tumor-free survival is 38 weeks (J:116130)

tumorigenesis
• 6 of 10 mice develop pancreatic ductal adenocarcinoma (J:116130)
• 6 of 10 mice develop pancreatic ductal adenocarcinoma (J:116130)




Genotype
MGI:3844659
cn9
Allelic
Composition
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Myf6tm1(cre)Mrc/Myf6+
Pax3tm1Mrc/Pax3tm1Mrc
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm4Rdp mutation (0 available); any Cdkn2a mutation (26 available)
Myf6tm1(cre)Mrc mutation (0 available); any Myf6 mutation (3 available)
Pax3tm1Mrc mutation (0 available); any Pax3 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
tumorigenesis
• 4 in 14 mice develop an rhabdomyosarcoma by day 56 to 89 (J:93444)
• 4 in 14 mice develop an rhabdomyosarcoma by day 56 to 89 (J:93444)

Mouse Models of Human Disease
OMIM ID Ref(s)
Rhabdomyosarcoma 2; RMS2 268220 J:93444




Genotype
MGI:5491219
cn10
Allelic
Composition
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Krastm4Tyj/Kras+
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm4Rdp mutation (0 available); any Cdkn2a mutation (26 available)
Krastm4Tyj mutation (4 available); any Kras mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
tumorigenesis
• mice develop multiple, aggressive adenocarcinomas in the lungs bilaterally following intranasal delivery of an adenovirus expressing Cre recombinase (J:195492)
• tumor growth is reduced more following two 7.3 Gy fractions of radiation therapy than a single 11.6 Gy fraction (J:195492)
• tumors have decreased BrdU uptake 4 hours after radiation treatment compared to unirradiated tumors, indicating the presence of an intact G1 cell-cycle checkpoint (J:195492)
• mice develop multiple, aggressive adenocarcinomas in the lungs bilaterally following intranasal delivery of an adenovirus expressing Cre recombinase (J:195492)
• tumor growth is reduced more following two 7.3 Gy fractions of radiation therapy than a single 11.6 Gy fraction (J:195492)
• tumors have decreased BrdU uptake 4 hours after radiation treatment compared to unirradiated tumors, indicating the presence of an intact G1 cell-cycle checkpoint (J:195492)

Mouse Models of Human Disease
OMIM ID Ref(s)
Lung Cancer 211980 J:195492




Genotype
MGI:5559056
cn11
Allelic
Composition
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Krastm4Tyj/Kras+
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm4Rdp mutation (0 available); any Cdkn2a mutation (26 available)
Krastm4Tyj mutation (4 available); any Kras mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
tumorigenesis
• mice injected intramuscularly with an adenovirus expressing Cre recombinase into the extremities or into the uterus develop soft tissue sarcomas (J:125101)
• mice injected intramuscularly with an adenovirus expressing Cre recombinase into the extremities or into the uterus develop soft tissue sarcomas (J:125101)




Genotype
MGI:3695430
cn12
Allelic
Composition
Cdkn2atm4Rdp/Cdkn2a+
Krastm4Tyj/Kras+
Tg(Pdx1-cre)89.1Dam/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm4Rdp mutation (0 available); any Cdkn2a mutation (26 available)
Krastm4Tyj mutation (4 available); any Kras mutation (30 available)
Tg(Pdx1-cre)89.1Dam mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• average tumor-free survival is 38 weeks (J:116130)
• average tumor-free survival is 38 weeks (J:116130)

tumorigenesis
• 6 of 10 mice develop pancreatic ductal adenocarcinoma (J:116130)
• 6 of 10 mice develop pancreatic ductal adenocarcinoma (J:116130)




Genotype
MGI:5441554
cn13
Allelic
Composition
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Krastm4Tyj/Kras+
Tg(Pdx1-cre)89.1Dam/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm4Rdp mutation (0 available); any Cdkn2a mutation (26 available)
Krastm4Tyj mutation (4 available); any Kras mutation (30 available)
Tg(Pdx1-cre)89.1Dam mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
tumorigenesis
• invasive ductal adenocarcinomas with extensive regional and distant metastases (J:187012)
• invasive ductal adenocarcinomas with extensive regional and distant metastases (J:187012)

Mouse Models of Human Disease
OMIM ID Ref(s)
Pancreatic Cancer 260350 J:187012




Genotype
MGI:2687217
cn14
Allelic
Composition
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Krastm4Tyj/Kras+
Tg(Pdx1-cre)89.1Dam/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm4Rdp mutation (0 available); any Cdkn2a mutation (26 available)
Krastm4Tyj mutation (4 available); any Kras mutation (30 available)
Tg(Pdx1-cre)89.1Dam mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• complete penetrance of death due to invasive and metastic cancer by 11 weeks of age (J:87196)
• complete penetrance of death due to invasive and metastic cancer by 11 weeks of age (J:87196)
• average tumor-free survival is 8.6 weeks (J:116130)
• average tumor-free survival is 8.6 weeks (J:116130)

tumorigenesis
• neoplasms frequently invade the lymphatic and vascular system, indicating metastatic invasion (J:87196)
• neoplasms frequently invade the lymphatic and vascular system, indicating metastatic invasion (J:87196)
• 11% of tumors exhibit metastasis (J:108298)
• 11% of tumors exhibit metastasis (J:108298)
• neoplasms rapidly progressed to become invasive and metastatic tumors (J:87196)
• neoplasms rapidly progressed to become invasive and metastatic tumors (J:87196)
• solid pancreatic tumors, frequently adhering to adjacent organs and the retroperitoneum (J:87196)
• tumors are highly invasive, frequently involving the duodenum, stomach, liver and/or spleen and occasionally obstructing the common bile duct (J:87196)
• solid pancreatic tumors, frequently adhering to adjacent organs and the retroperitoneum (J:87196)
• tumors are highly invasive, frequently involving the duodenum, stomach, liver and/or spleen and occasionally obstructing the common bile duct (J:87196)
• 26% of tumors exhibit anaplastic carcinoma histology (J:108298)
• 26% of tumors exhibit sarcomatoid differentiation (J:108298)
• 26% of tumors exhibit anaplastic carcinoma histology (J:108298)
• 26% of tumors exhibit sarcomatoid differentiation (J:108298)
• tumors exhibit pathologic features of human pancreatic ductal adenocarcinomas (J:87196)
• tumors exhibit pathologic features of human pancreatic ductal adenocarcinomas (J:87196)
• 48% of tumors exhibit well differentiated ductal adenocarcinoma histology (J:108298)
• 48% of tumors exhibit well differentiated ductal adenocarcinoma histology (J:108298)
• 6 of 6 mice develop pancreatic ductal adenocarcinoma (J:116130)
• 6 of 6 mice develop pancreatic ductal adenocarcinoma (J:116130)
• earlier onset (3-4 weeks of age) of local premalignant ductal lesions (pancreatic intraepithelial neoplasia) than in mice just expressing the oncogenic form KRAS2 and not deficient for Cdkn2a expression (J:87196)
• pancreatic ductal lesions progress rapidly to invasive pancreatic adenocarcinoma (J:87196)
• earlier onset (3-4 weeks of age) of local premalignant ductal lesions (pancreatic intraepithelial neoplasia) than in mice just expressing the oncogenic form KRAS2 and not deficient for Cdkn2a expression (J:87196)
• pancreatic ductal lesions progress rapidly to invasive pancreatic adenocarcinoma (J:87196)

Mouse Models of Human Disease
OMIM ID Ref(s)
Pancreatic Cancer 260350 J:87196 , J:108298




Genotype
MGI:5308806
cn15
Allelic
Composition
Cdkn2atm4Rdp/Cdkn2a+
Krastm4Tyj/Kras+
Tg(Pdx1-cre)89.1Dam/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm4Rdp mutation (0 available); any Cdkn2a mutation (26 available)
Krastm4Tyj mutation (4 available); any Kras mutation (30 available)
Tg(Pdx1-cre)89.1Dam mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
tumorigenesis
• 69% of tumors exhibit metastasis (J:108298)
• 69% of tumors exhibit metastasis (J:108298)
• mutants develop pancreatic tumors with an average latency of 34.2 weeks (J:108298)
• 43% of tumors exhibit sarcomatoid differentiation (J:108298)
• 43% of tumors exhibit sarcomatoid differentiation (J:108298)
• mutants develop pancreatic tumors with an average latency of 34.2 weeks (J:108298)
• 57% of tumors exhibit well differentiated ductal adenocarcinoma histology (J:108298)
• 57% of tumors exhibit well differentiated ductal adenocarcinoma histology (J:108298)




Genotype
MGI:4355874
cn16
Allelic
Composition
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Krastm4Tyj/Krastm4Tyj
Tg(Pdx1-cre)89.1Dam/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm4Rdp mutation (0 available); any Cdkn2a mutation (26 available)
Krastm4Tyj mutation (4 available); any Kras mutation (30 available)
Tg(Pdx1-cre)89.1Dam mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands

tumorigenesis
• mice develop invasive pancreatic masses that are firm and homogeneous unlike in wild-type mice (J:151781)
• mice develop invasive pancreatic masses that are firm and homogeneous unlike in wild-type mice (J:151781)

homeostasis/metabolism
• PET scans detected abnormal metabolic activity in the abdomen unlike in wild-type mice (J:151781)
• PET scans detected abnormal metabolic activity in the abdomen unlike in wild-type mice (J:151781)




Genotype
MGI:2687205
cn17
Allelic
Composition
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Tg(Pdx1-cre)89.1Dam/0
Genetic
Background
involves: C57BL/6 * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm4Rdp mutation (0 available); any Cdkn2a mutation (26 available)
Tg(Pdx1-cre)89.1Dam mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
tumorigenesis
N
• no neoplastic lesions or tumors were observed in the pancreas (J:87196)
• no neoplastic lesions or tumors were observed in the pancreas (J:87196)





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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory