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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cdkn2atm4Rdp
targeted mutation 4, Ronald DePinho
MGI:2687203
Summary 18 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Krastm4Tyj/Kras+
Smad4tm1Rdp/Smad4tm1Rdp
Ptf1atm1.1(cre)Cvw/Ptf1a+
involves: 129 * FVB/N MGI:3695428
cn2
Cdkn2atm4Rdp/Cdkn2a+
Krastm4Tyj/Kras+
Smad4tm1Rdp/Smad4tm1Rdp
Ptf1atm1.1(cre)Cvw/Ptf1a+
involves: 129 * FVB/N MGI:3695424
cn3
Braftm1Mmcm/Braf+
Cdkn2atm4Rdp/Cdkn2atm4Rdp
involves: 129P2/OlaHsd MGI:3712026
cn4
Cdkn2atm4Rdp/Cdkn2a+
Krastm4Tyj/Kras+
Ptf1atm1.1(cre)Cvw/Ptf1a+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ MGI:3695432
cn5
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Krastm4Tyj/Kras+
Ptf1atm1.1(cre)Cvw/Ptf1a+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ MGI:3695431
cn6
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Nf1tm1Par/Nf1tm1Par
involves: 129S1/Sv * 129X1/SvJ MGI:5792147
cn7
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Myf6tm1(cre)Mrc/Myf6+
Pax3tm1Mrc/Pax3tm1Mrc
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:3844659
cn8
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Krastm4Tyj/Kras+
involves: 129S4/SvJae MGI:5491219
cn9
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Krastm4Tyj/Kras+
involves: 129S4/SvJae * C57BL/6 MGI:5559056
cn10
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Krastm4Tyj/Kras+
Tg(Pdx1-cre)89.1Dam/0
involves: 129S4/SvJae * C57BL/6 * CBA MGI:5441554
cn11
Cdkn2atm4Rdp/Cdkn2a+
Krastm4Tyj/Kras+
Tg(Pdx1-cre)89.1Dam/0
involves: 129S4/SvJae * C57BL/6 * CBA MGI:3695430
cn12
Cdkn2atm4Rdp/Cdkn2a+
Krastm4Tyj/Kras+
Tg(Pdx1-cre)89.1Dam/0
involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N MGI:5308806
cn13
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Krastm4Tyj/Kras+
Tg(Pdx1-cre)89.1Dam/0
involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N MGI:2687217
cn14
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Krastm4Tyj/Krastm4Tyj
Tg(Pdx1-cre)89.1Dam/0
involves: 129S4/SvJae * C57BL/6 * DBA/2 MGI:4355874
cn15
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Krastm4Tyj/Kras+
Smad4tm1Rdp/Smad4tm1Rdp
Tg(Pdx1-cre)89.1Dam/0
involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA * FVB/N MGI:3695429
cn16
Cdkn2atm4Rdp/Cdkn2a+
Krastm4Tyj/Kras+
Smad4tm1Rdp/Smad4tm1Rdp
Tg(Pdx1-cre)89.1Dam/0
involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA * FVB/N MGI:3695426
cn17
Cdkn2atm4Rdp/Cdkn2a+
Smad4tm1Rdp/Smad4tm1Rdp
Tg(Pdx1-cre)89.1Dam/0
involves: 129S/SvEv * C57BL/6 * CBA * FVB/N MGI:3695427
cn18
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Tg(Pdx1-cre)89.1Dam/0
involves: C57BL/6 * CBA * FVB/N MGI:2687205


Genotype
MGI:3695428
cn1
Allelic
Composition
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Krastm4Tyj/Kras+
Smad4tm1Rdp/Smad4tm1Rdp
Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic
Background
involves: 129 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm4Rdp mutation (0 available); any Cdkn2a mutation (30 available)
Krastm4Tyj mutation (4 available); any Kras mutation (32 available)
Ptf1atm1.1(cre)Cvw mutation (1 available); any Ptf1a mutation (10 available)
Smad4tm1Rdp mutation (0 available); any Smad4 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• 4 of 4 mice develop pancreatic ductal adenocarcinoma
• the proportion of undifferentiated carcinomas is decreased compared to mice wild-type for Smad4
• tumor fibrosis is increased compared to mice wild-type for Smad4

mortality/aging
• average tumor-free survival is 8.8 weeks

neoplasm
• 4 of 4 mice develop pancreatic ductal adenocarcinoma
• the proportion of undifferentiated carcinomas is decreased compared to mice wild-type for Smad4
• tumor fibrosis is increased compared to mice wild-type for Smad4




Genotype
MGI:3695424
cn2
Allelic
Composition
Cdkn2atm4Rdp/Cdkn2a+
Krastm4Tyj/Kras+
Smad4tm1Rdp/Smad4tm1Rdp
Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic
Background
involves: 129 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm4Rdp mutation (0 available); any Cdkn2a mutation (30 available)
Krastm4Tyj mutation (4 available); any Kras mutation (32 available)
Ptf1atm1.1(cre)Cvw mutation (1 available); any Ptf1a mutation (10 available)
Smad4tm1Rdp mutation (0 available); any Smad4 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• 12 of 13 mice develop pancreatic ductal adenocarcinoma
• the proportion of undifferentiated carcinomas is decreased compared to mice wild-type for Smad4

mortality/aging
• average tumor-free survival is 14 weeks

neoplasm
• 5 of 13 mice develop intraductal papillary mucinous neoplasms
• tumor fibrosis is increased compared to mice wild-type for Smad4
• 12 of 13 mice develop pancreatic ductal adenocarcinoma
• the proportion of undifferentiated carcinomas is decreased compared to mice wild-type for Smad4




Genotype
MGI:3712026
cn3
Allelic
Composition
Braftm1Mmcm/Braf+
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braftm1Mmcm mutation (2 available); any Braf mutation (30 available)
Cdkn2atm4Rdp mutation (0 available); any Cdkn2a mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• Cre-treated mice show scattered papillary adenomas with evidence of subpleural nodules harboring cords of atypical cells trapped within regions of mesenchymal proliferation
• 2/4 mice display multiple lung tumors with a bronchioalveolar component

neoplasm
• Cre-treated mice show scattered papillary adenomas with evidence of subpleural nodules harboring cords of atypical cells trapped within regions of mesenchymal proliferation
• 2/4 mice display multiple lung tumors with a bronchioalveolar component




Genotype
MGI:3695432
cn4
Allelic
Composition
Cdkn2atm4Rdp/Cdkn2a+
Krastm4Tyj/Kras+
Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm4Rdp mutation (0 available); any Cdkn2a mutation (30 available)
Krastm4Tyj mutation (4 available); any Kras mutation (32 available)
Ptf1atm1.1(cre)Cvw mutation (1 available); any Ptf1a mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• 6 of 10 mice develop pancreatic ductal adenocarcinoma

mortality/aging
• average tumor-free survival is 38 weeks

neoplasm
• 6 of 10 mice develop pancreatic ductal adenocarcinoma




Genotype
MGI:3695431
cn5
Allelic
Composition
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Krastm4Tyj/Kras+
Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm4Rdp mutation (0 available); any Cdkn2a mutation (30 available)
Krastm4Tyj mutation (4 available); any Kras mutation (32 available)
Ptf1atm1.1(cre)Cvw mutation (1 available); any Ptf1a mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• 6 of 6 mice develop pancreatic ductal adenocarcinoma

mortality/aging
• average tumor-free survival is 8.6 weeks

neoplasm
• 6 of 6 mice develop pancreatic ductal adenocarcinoma




Genotype
MGI:5792147
cn6
Allelic
Composition
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Nf1tm1Par/Nf1tm1Par
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm4Rdp mutation (0 available); any Cdkn2a mutation (30 available)
Nf1tm1Par mutation (4 available); any Nf1 mutation (85 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mice injected intramuscularly with an adenovirus expressing cre recombinase (Ad-Cre) develop soft-tissue sarcomas in the region 3 to 12 months after cre exposure
• intramuscular injections of Ad-cre generates a spectrum of high-grade spindle cell sarcomas, including rhabdomyosarcoma and undifferentiated pleomorphic sarcoma
• tumors from both intramuscular and sciatic nerve Ad-Cre injected mice show significant infiltration of mast cells
• tumors arising from intramuscular Ad-Cre injection show higher proliferation than tumors arising from sciatic nerve Ad-Cre injection
• treatment of tumor cells isolated from intramuscularly Ad-Cre injected mice with the MEK inhibitor PD325901results in decreases colony-forming units and cell proliferation
• treatment of Ad-Cre intramuscularly injected mice with the MEK inhibitor PD325901 delays tumor growth, reduces proliferative index of tumors, and decreases CD31+ microvessel density but does not alter mast cell levels in tumors
• intramuscularly Ad-Cre injected mice develop rhabdomyosarcoma
• mice injected with Ad-Cre in the sciatic nerve develop malignant peripheral nerve sheath tumors in the region at a mean time of 4.1 months after cre exposure

muscle
• intramuscularly Ad-Cre injected mice develop rhabdomyosarcoma

nervous system
• mice injected with Ad-Cre in the sciatic nerve develop malignant peripheral nerve sheath tumors in the region at a mean time of 4.1 months after cre exposure




Genotype
MGI:3844659
cn7
Allelic
Composition
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Myf6tm1(cre)Mrc/Myf6+
Pax3tm1Mrc/Pax3tm1Mrc
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm4Rdp mutation (0 available); any Cdkn2a mutation (30 available)
Myf6tm1(cre)Mrc mutation (0 available); any Myf6 mutation (8 available)
Pax3tm1Mrc mutation (0 available); any Pax3 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• 4 in 14 mice develop an rhabdomyosarcoma by day 56 to 89

neoplasm
• 4 in 14 mice develop an rhabdomyosarcoma by day 56 to 89

Mouse Models of Human Disease
OMIM ID Ref(s)
Rhabdomyosarcoma 2; RMS2 268220 J:93444




Genotype
MGI:5491219
cn8
Allelic
Composition
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Krastm4Tyj/Kras+
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm4Rdp mutation (0 available); any Cdkn2a mutation (30 available)
Krastm4Tyj mutation (4 available); any Kras mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• mice develop multiple, aggressive adenocarcinomas in the lungs bilaterally following intranasal delivery of an adenovirus expressing Cre recombinase
• tumor growth is reduced more following two 7.3 Gy fractions of radiation therapy than a single 11.6 Gy fraction
• tumors have decreased BrdU uptake 4 hours after radiation treatment compared to unirradiated tumors, indicating the presence of an intact G1 cell-cycle checkpoint

neoplasm
• mice develop multiple, aggressive adenocarcinomas in the lungs bilaterally following intranasal delivery of an adenovirus expressing Cre recombinase
• tumor growth is reduced more following two 7.3 Gy fractions of radiation therapy than a single 11.6 Gy fraction
• tumors have decreased BrdU uptake 4 hours after radiation treatment compared to unirradiated tumors, indicating the presence of an intact G1 cell-cycle checkpoint

Mouse Models of Human Disease
OMIM ID Ref(s)
Lung Cancer 211980 J:195492




Genotype
MGI:5559056
cn9
Allelic
Composition
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Krastm4Tyj/Kras+
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm4Rdp mutation (0 available); any Cdkn2a mutation (30 available)
Krastm4Tyj mutation (4 available); any Kras mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mice injected intramuscularly with an adenovirus expressing Cre recombinase into the extremities or into the uterus develop soft tissue sarcomas




Genotype
MGI:5441554
cn10
Allelic
Composition
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Krastm4Tyj/Kras+
Tg(Pdx1-cre)89.1Dam/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm4Rdp mutation (0 available); any Cdkn2a mutation (30 available)
Krastm4Tyj mutation (4 available); any Kras mutation (32 available)
Tg(Pdx1-cre)89.1Dam mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• invasive ductal adenocarcinomas with extensive regional and distant metastases

neoplasm
• invasive ductal adenocarcinomas with extensive regional and distant metastases

Mouse Models of Human Disease
OMIM ID Ref(s)
Pancreatic Cancer 260350 J:187012




Genotype
MGI:3695430
cn11
Allelic
Composition
Cdkn2atm4Rdp/Cdkn2a+
Krastm4Tyj/Kras+
Tg(Pdx1-cre)89.1Dam/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm4Rdp mutation (0 available); any Cdkn2a mutation (30 available)
Krastm4Tyj mutation (4 available); any Kras mutation (32 available)
Tg(Pdx1-cre)89.1Dam mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• 6 of 10 mice develop pancreatic ductal adenocarcinoma

mortality/aging
• average tumor-free survival is 38 weeks

neoplasm
• 6 of 10 mice develop pancreatic ductal adenocarcinoma




Genotype
MGI:5308806
cn12
Allelic
Composition
Cdkn2atm4Rdp/Cdkn2a+
Krastm4Tyj/Kras+
Tg(Pdx1-cre)89.1Dam/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm4Rdp mutation (0 available); any Cdkn2a mutation (30 available)
Krastm4Tyj mutation (4 available); any Kras mutation (32 available)
Tg(Pdx1-cre)89.1Dam mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• mutants develop pancreatic tumors with an average latency of 34.2 weeks
• 43% of tumors exhibit sarcomatoid differentiation
• 57% of tumors exhibit well differentiated ductal adenocarcinoma histology

neoplasm
• mutants develop pancreatic tumors with an average latency of 34.2 weeks
• 43% of tumors exhibit sarcomatoid differentiation
• 57% of tumors exhibit well differentiated ductal adenocarcinoma histology
• 69% of tumors exhibit metastasis




Genotype
MGI:2687217
cn13
Allelic
Composition
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Krastm4Tyj/Kras+
Tg(Pdx1-cre)89.1Dam/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm4Rdp mutation (0 available); any Cdkn2a mutation (30 available)
Krastm4Tyj mutation (4 available); any Kras mutation (32 available)
Tg(Pdx1-cre)89.1Dam mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• solid pancreatic tumors, frequently adhering to adjacent organs and the retroperitoneum (J:87196)
• tumors are highly invasive, frequently involving the duodenum, stomach, liver and/or spleen and occasionally obstructing the common bile duct (J:87196)
• 26% of tumors exhibit anaplastic carcinoma histology (J:108298)
• 26% of tumors exhibit sarcomatoid differentiation (J:108298)
• tumors exhibit pathologic features of human pancreatic ductal adenocarcinomas (J:87196)
• 48% of tumors exhibit well differentiated ductal adenocarcinoma histology (J:108298)
• 6 of 6 mice develop pancreatic ductal adenocarcinoma (J:116130)
• earlier onset (3-4 weeks of age) of local premalignant ductal lesions (pancreatic intraepithelial neoplasia) than in mice just expressing the oncogenic form KRAS2 and not deficient for Cdkn2a expression
• pancreatic ductal lesions progress rapidly to invasive pancreatic adenocarcinoma

mortality/aging
• complete penetrance of death due to invasive and metastic cancer by 11 weeks of age (J:87196)
• average tumor-free survival is 8.6 weeks (J:116130)

neoplasm
• solid pancreatic tumors, frequently adhering to adjacent organs and the retroperitoneum (J:87196)
• tumors are highly invasive, frequently involving the duodenum, stomach, liver and/or spleen and occasionally obstructing the common bile duct (J:87196)
• 26% of tumors exhibit anaplastic carcinoma histology (J:108298)
• 26% of tumors exhibit sarcomatoid differentiation (J:108298)
• tumors exhibit pathologic features of human pancreatic ductal adenocarcinomas (J:87196)
• 48% of tumors exhibit well differentiated ductal adenocarcinoma histology (J:108298)
• 6 of 6 mice develop pancreatic ductal adenocarcinoma (J:116130)
• earlier onset (3-4 weeks of age) of local premalignant ductal lesions (pancreatic intraepithelial neoplasia) than in mice just expressing the oncogenic form KRAS2 and not deficient for Cdkn2a expression
• pancreatic ductal lesions progress rapidly to invasive pancreatic adenocarcinoma
• neoplasms frequently invade the lymphatic and vascular system, indicating metastatic invasion (J:87196)
• 11% of tumors exhibit metastasis (J:108298)
• neoplasms rapidly progressed to become invasive and metastatic tumors

Mouse Models of Human Disease
OMIM ID Ref(s)
Pancreatic Cancer 260350 J:87196 , J:108298




Genotype
MGI:4355874
cn14
Allelic
Composition
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Krastm4Tyj/Krastm4Tyj
Tg(Pdx1-cre)89.1Dam/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm4Rdp mutation (0 available); any Cdkn2a mutation (30 available)
Krastm4Tyj mutation (4 available); any Kras mutation (32 available)
Tg(Pdx1-cre)89.1Dam mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Pancreatic tumors in Krastm4Tyj/Krastm4Tyj Trim33tm1Los/Trim33tm1Los Tg(Pdx1-cre)89.1Dam/0 and Krastm4Tyj/Krastm4Tyj Cdkn2atm4Rdp/Cdkn2atm4Rdp Tg(Pdx1-cre)89.1Dam/0 mice

endocrine/exocrine glands
• mice develop invasive pancreatic masses that are firm and homogeneous unlike in wild-type mice

neoplasm
• mice develop invasive pancreatic masses that are firm and homogeneous unlike in wild-type mice

homeostasis/metabolism
• PET scans detected abnormal metabolic activity in the abdomen unlike in wild-type mice




Genotype
MGI:3695429
cn15
Allelic
Composition
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Krastm4Tyj/Kras+
Smad4tm1Rdp/Smad4tm1Rdp
Tg(Pdx1-cre)89.1Dam/0
Genetic
Background
involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm4Rdp mutation (0 available); any Cdkn2a mutation (30 available)
Krastm4Tyj mutation (4 available); any Kras mutation (32 available)
Smad4tm1Rdp mutation (0 available); any Smad4 mutation (24 available)
Tg(Pdx1-cre)89.1Dam mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• 9 of 10 mice develop pancreatic ductal adenocarcinoma
• the proportion of undifferentiated carcinomas is decreased compared to mice wild-type for Smad4

digestive/alimentary system
• 5 of 10 mice develop gastric cancer

mortality/aging
• average tumor-free survival is 7.4 weeks

neoplasm
• 3 of 10 mice develop intraductal papillary mucinous neoplasms
• tumor fibrosis is increased compared to mice wild-type for Smad4
• 5 of 10 mice develop gastric cancer
• 9 of 10 mice develop pancreatic ductal adenocarcinoma
• the proportion of undifferentiated carcinomas is decreased compared to mice wild-type for Smad4




Genotype
MGI:3695426
cn16
Allelic
Composition
Cdkn2atm4Rdp/Cdkn2a+
Krastm4Tyj/Kras+
Smad4tm1Rdp/Smad4tm1Rdp
Tg(Pdx1-cre)89.1Dam/0
Genetic
Background
involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm4Rdp mutation (0 available); any Cdkn2a mutation (30 available)
Krastm4Tyj mutation (4 available); any Kras mutation (32 available)
Smad4tm1Rdp mutation (0 available); any Smad4 mutation (24 available)
Tg(Pdx1-cre)89.1Dam mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• 8 of 12 mice develop gastric cancer

endocrine/exocrine glands
• 4 of 12 mice develop pancreatic ductal adenocarcinoma
• the proportion of undifferentiated carcinomas is decreased compared to mice wild-type for Smad4

mortality/aging
• average tumor-free survival is 12.6 weeks

neoplasm
• 4 of 12 mice develop intraductal papillary mucinous neoplasms
• tumor fibrosis is increased compared to mice wild-type for Smad4
• 8 of 12 mice develop gastric cancer
• 4 of 12 mice develop pancreatic ductal adenocarcinoma
• the proportion of undifferentiated carcinomas is decreased compared to mice wild-type for Smad4




Genotype
MGI:3695427
cn17
Allelic
Composition
Cdkn2atm4Rdp/Cdkn2a+
Smad4tm1Rdp/Smad4tm1Rdp
Tg(Pdx1-cre)89.1Dam/0
Genetic
Background
involves: 129S/SvEv * C57BL/6 * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm4Rdp mutation (0 available); any Cdkn2a mutation (30 available)
Smad4tm1Rdp mutation (0 available); any Smad4 mutation (24 available)
Tg(Pdx1-cre)89.1Dam mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
N
• tumor-free survival is greater than 52 weeks and only 1 of 10 mice developed an intraductal papillary mucinous neoplasm




Genotype
MGI:2687205
cn18
Allelic
Composition
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Tg(Pdx1-cre)89.1Dam/0
Genetic
Background
involves: C57BL/6 * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm4Rdp mutation (0 available); any Cdkn2a mutation (30 available)
Tg(Pdx1-cre)89.1Dam mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
N
• no neoplastic lesions or tumors were observed in the pancreas





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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory