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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Urodtm1Kush
targeted mutation 1, James P Kushner
MGI:2687172
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Urodtm1Kush/Urodtm1Kush involves: 129S1/Sv * 129X1/SvJ MGI:2687182
ht2
Urodtm1Kush/Urod+ involves: 129S1/Sv * 129X1/SvJ MGI:2687184
cx3
Hfetm2Nca/Hfetm2Nca
Urodtm1Kush/Urod+
involves: C57BL/6J MGI:2687183


Genotype
MGI:2687182
hm1
Allelic
Composition
Urodtm1Kush/Urodtm1Kush
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Urodtm1Kush mutation (0 available); any Urod mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:2687184
ht2
Allelic
Composition
Urodtm1Kush/Urod+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Urodtm1Kush mutation (0 available); any Urod mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• hepatic iron concentrations did not differ from those of wild-type mice through 1 year of age, though treatment with iron dextran elicited a significantly higher increase in hepatic iron in mutant mice than in wild-type mice
• urinary porphyrin concentrations did not differ from those of wild-type mice prior to treatment with delta-aminolevulinic acid (ALA), though treatment with either ALA alone or with both ALA and iron elicited significantly higher increases in porphyrin concentrations than in mutant mice than in wild-type mice




Genotype
MGI:2687183
cx3
Allelic
Composition
Hfetm2Nca/Hfetm2Nca
Urodtm1Kush/Urod+
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hfetm2Nca mutation (1 available); any Hfe mutation (14 available)
Urodtm1Kush mutation (0 available); any Urod mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• increased urinary porphyrin concentration (hepatic levels were also increased)

liver/biliary system

Mouse Models of Human Disease
OMIM ID Ref(s)
Porphyria Cutanea Tarda 176100 J:66704





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory