Mouse Genome Informatics
hm1
    Urodtm1Kush/Urodtm1Kush
involves: 129S1/Sv * 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• no fetuses observed between E7.5 and E9.5


Mouse Genome Informatics
ht2
    Urodtm1Kush/Urod+
involves: 129S1/Sv * 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
normal phenotype
• hepatic iron concentrations did not differ from those of wild-type mice through 1 year of age, though treatment with iron dextran elicited a significantly higher increase in hepatic iron in mutant mice than in wild-type mice
• urinary porphyrin concentrations did not differ from those of wild-type mice prior to treatment with delta-aminolevulinic acid (ALA), though treatment with either ALA alone or with both ALA and iron elicited significantly higher increases in porphyrin concentrations than in mutant mice than in wild-type mice


Mouse Genome Informatics
cx3
    Hfetm2Nca/Hfetm2Nca
Urodtm1Kush/Urod+

involves: C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
homeostasis/metabolism
• increased urinary porphyrin concentration (hepatic levels were also increased)

liver/biliary system

Mouse Models of Human Disease
OMIM IDRef(s)
Porphyria Cutanea Tarda 176100 J:66704