About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mpltm1Fjs
targeted mutation 1, Frederic J de Sauvage
MGI:2686901
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Mpltm1Fjs/Mpltm1Fjs involves: 129 * C57BL/6J MGI:2686902


Genotype
MGI:2686902
hm1
Allelic
Composition
Mpltm1Fjs/Mpltm1Fjs
Genetic
Background
involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mpltm1Fjs mutation (0 available); any Mpl mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• levels of megakaryocyte progenitors reduced by about 50%
• fewer megakaryocytes generated in response to thrombopoietin and the ploidy of cells produced was lower
• less of an increase in platelets 5 days after thrombopoietin treatment

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
congenital amegakaryocytic thrombocytopenia DOID:0090118 OMIM:604498
J:87416





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/10/2017
MGI 6.10
The Jackson Laboratory