Phenotypes associated with this allele

• Allele Symbol: Mpl^tm1Fjs
• Allele Name: targeted mutation 1, Frederic J de Sauvage
• Allele ID: MGI:2686901
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mpl^tm1Fjs/Mpl^tm1Fjs	involves: 129 * C57BL/6J	MGI:2686902

Genotype
MGI:2686902

hm1

• Allelic Composition: Mpl^tm1Fjs/Mpl^tm1Fjs
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal definitive hematopoiesis ( J:87416 )

abnormal megakaryocyte progenitor cell morphology ( J:87416 )

• levels of megakaryocyte progenitors reduced by about 50%

• fewer megakaryocytes generated in response to thrombopoietin and the ploidy of cells produced was lower

• less of an increase in platelets 5 days after thrombopoietin treatment

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
congenital amegakaryocytic thrombocytopenia		DOID:0090118	OMIM:604498	J:87416