Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptk2tm1Ilic mutation
(0 available);
any
Ptk2 mutation
(90 available)
Ptk2tm1Lfr mutation
(1 available);
any
Ptk2 mutation
(90 available)
Tg(KRT5-cre)5132Jlj mutation
(1 available)
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endocrine/exocrine glands
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• a significant deficit in sebaceous glands in 2-4 month-old mice
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integument
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• primary keratinocytes isolated from mutant animals would not proliferate in culture
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• a significant deficit in sebaceous glands in 2-4 month-old mice
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• from approximately postnatal day 7 until P17, initial hair growth was sparse
• by P17, the pelage of mutant mice appeared identical to their normal littermates
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• hair follicles are orientated randomly, rather than being arrayed in a hexagonal pattern as in control in P12 mice
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• have consistently about 25% fewer hair follicles than control
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• irregular hair cycle suggested by the presence of hair follicles in the hypodermis of P22 mice
• adult mutant mice periodically showed patches of receding hair, which lasted for several days, disappeared, and then appeared again at another location
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• a thinner epidermis was evident in mutant mice at all ages
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cellular
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• primary keratinocytes isolated from mutant animals would not proliferate in culture
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptk2tm1Lfr mutation
(1 available);
any
Ptk2 mutation
(90 available)
Tg(Tek-cre)1Rwng mutation
(0 available)
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mortality/aging
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• lethality between E10.5 and E11.5
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growth/size/body
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• slightly smaller at E10.5
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embryo
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• yolk sacs exhibit wider capillary diameters, fewer small intercapillary spaces, and larger intercapillary areas that are often associated with incomplete vascular sprouts at E9.5
• yolk sacs lack the hierarchical vitelline vascular pattern and show only remnants of major vessels
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• the capillary plexuses lack the intricate network structure and instead the microvessels are irregularly shaped, frequently dilated, and flattened with a sheet-like appearance and thin, spiky connections
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• slightly smaller at E10.5
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cardiovascular system
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• show patches of sequestered blood, reflecting dilated vessels, primarily in the upper trunk and head regions
• vessels in the head appear flat and fused to the surrounding widened and sinusoidal capillaries
• para-aortic splanchnopleural mesoderm explants undergo a process in which endothelial cells contract and cluster with each other, resulting in an irregular network composed of wider and smaller vessels
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• isolated endothelial cells grown on fibronectin are poorly spread, lack membrane ruffling and lamellipodia formation and show aberrant locomotion that is faster in the presence of serum and growth supplements
• endothelial cells show fewer and abnormal stress fibers that instead resemble cortical actin bundles and show fewer focal adhesions
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• vessels in the head appear flat and fused to the surrounding widened and sinusoidal capillaries, leading to a great variation in the size of the capillaries and intercapillary spaces
• allantoic explants and para-aortic splanchnopleural mesoderm explants show dilation of capillaries and intercapillary spaces with a reduction in network complexity
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• endothelial cell explants show no decrease in proliferation or migration but show an increase in cell retraction and death leading to reduced vessel growth and increased vessel regression
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• exhibit complete absence of blood vessels in the neuroepithelium at E10.5, indicating defective sprouting angiogenesis into the neuroepithelium
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• yolk sacs exhibit wider capillary diameters, fewer small intercapillary spaces, and larger intercapillary areas that are often associated with incomplete vascular sprouts at E9.5
• yolk sacs lack the hierarchical vitelline vascular pattern and show only remnants of major vessels
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• the capillary plexuses lack the intricate network structure and instead the microvessels are irregularly shaped, frequently dilated, and flattened with a sheet-like appearance and thin, spiky connections
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• hemorrhage is apparent in both the amniotic and yolk sac cavities
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cellular
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• endothelial cell explants show no decrease in proliferation or migration but show an increase in cell retraction and death leading to reduced vessel growth and increased vessel regression
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immune system
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• atrophy of the thymic cortex
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• about 2/3 of mutants start to show a decrease in the number of thymocytes after 3 weeks of age, with numbers dropping as low as 1/100 of normal at 4 to 5 weeks of age
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• impaired development of CD4+CD8+ thymocytes
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• exhibit a reduction in double-positive thymocytes coincident with cortical atrophy
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hematopoietic system
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• atrophy of the thymic cortex
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• about 2/3 of mutants start to show a decrease in the number of thymocytes after 3 weeks of age, with numbers dropping as low as 1/100 of normal at 4 to 5 weeks of age
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• impaired development of CD4+CD8+ thymocytes
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• exhibit a reduction in double-positive thymocytes coincident with cortical atrophy
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endocrine/exocrine glands
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• atrophy of the thymic cortex
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• about 2/3 of mutants start to show a decrease in the number of thymocytes after 3 weeks of age, with numbers dropping as low as 1/100 of normal at 4 to 5 weeks of age
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